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STOCK COMPARISON

Genscript Biotech vs Vertex Pharmaceuticals: Fair Value & Quality

Both stocks run through our valuation models. Here is how Genscript Biotech (1548) and Vertex Pharmaceuticals (VRTX) compare, as of Oct 1, 2026.

As of Oct 1, 2026, Fair Value Calculator sees Vertex Pharmaceuticals as the more attractively valued of the two: Genscript Biotech trades at HK$44.86 versus a fair value of HK$22.17 (−50.6%), while Vertex Pharmaceuticals trades at $523 versus $580 (+11.0%).
Genscript Biotech
1548.HK · HKD · Health Care
−50.6%
upside to fair value
overvalued
PriceHK$44.86
Fair ValueHK$22.17
Quality55/100
Vertex Pharmaceuticals
VRTX · USD · Health Care
+11.0%
upside to fair value
undervalued
Price$523
Fair Value$580
Quality80/100
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Head-to-head numbers

Green is the better side of a row, red the weaker one (for valuation multiples: lower = cheaper). Grey rows are for reference only and are not scored.

betterweakerfor reference, not scored

Genscript BiotechVertex Pharmaceuticals
Valuation
n/aP/E (TTM)30.4×
54.4×P/E ex one-offs (FY2025)31.1×
n/aForward P/E (FY2027)26.0×
n/aMedian P/E at FY-end (8 FY, ex one-offs where documented)25.7×
14.79×P/S (TTM)10.62×
3.16×P/B7.16×
64.0×EV/EBITDA25.3×
n/aPEG1.89×
−50.6%Fair value upside+11.0%
Profitability
12.3%Operating margin38.1%
n/aEBIT margin trend (5Y)0.86×
-15.3%Return on equity23.5%
1.5%Return on assets11.9%
Growth
-22.1%Revenue growth (YoY)12.5%
15.3%Avg. growth/yr (3Y)10.6%
19.7%Avg. growth/yr (5Y)14.2%
n/aValue creation/yr+13.5%
Balance & size
14.7×Interest coverage (EBIT/interest)357.9×
n/aDebt / equity0.03×
$12BMarket cap$134B
mixedGrowth qualityhealthy
The P/E excluding one-off items is scored: for at least one of the two companies, special items (write-downs, restructuring, litigation) move the reported P/E by 15 % or more. The trailing P/E is shown for reference.
Vertex Pharmaceuticals, median P/E at fiscal year-end, 8 fiscal years (2017 to 2025), reported earnings, 5 of the years ex one-offs: 25.7.
Forward P/E: price divided by the analyst consensus for the first fiscal year that has not started yet. The current year carries special items from quarters already reported.

Vertex Pharmaceuticals leads: 3 to 8 metric wins.

n/a = not meaningfully computable, for example with negative equity.

Quality in detail

The quality score, broken down into the same factor families as on the stock page, 0 to 100 per family.

Genscript Biotechof which business quality 60 · market factors 80 Vertex Pharmaceuticalsof which business quality 78 · market factors 72
ProfitabilityMargins and returns on capital today
5
72
Quality GrowthAre margins and returns improving?
79
65
CashflowEarnings quality: real cash, not paper profit
89
79
Fin. StrengthBalance sheet, leverage, solvency risk
82
92
InvestmentDisciplined investing over empire-building
21
58
Low VolatilityCalm price path (market factor)
32
85
MomentumPrice trend over the last 3–12 months (market factor)
100
63
52W MomentumDistance to the 52-week high (market factor)
100
74
Net IssuanceShare count: buybacks or dilution?
77
89

What the models say

How far the median fair value (base case) per model family sits from the current price, in percent. The amount in the currency of the trading venue is shown underneath.

above the price, more than 15% above close to the price, 85% to 115% of the price below the price, more than 15% below

Model familyGenscript BiotechPrice HK$44.86Vertex PharmaceuticalsPrice $523
DCF Models−47.6%below the priceHK$23.52−13.2%close to the price$454
Earnings-Based−82.2%below the priceHK$7.99−1.2%close to the price$517
Multiples−65.4%below the priceHK$15.53−46.7%below the price$279
Asset-Based−79.6%below the priceHK$9.13−90.6%below the price$49.34
Growth DCF−49.4%below the priceHK$22.72−33.2%below the price$349
Economic Profit−82.2%below the priceHK$7.99−53.2%below the price$245
Growth Earningsn/a+32.6%above the price$693
Minimum−82.2%below the priceHK$7.99−90.6%below the price$49.34
Maximum−47.6%below the priceHK$23.52+32.6%above the price$693
Median−72.5%below the priceHK$12.33−33.2%below the price$349
Geometric mean−71.0%below the priceHK$13.00−43.7%below the price$294

Minimum, maximum, median and geometric mean refer to the family values in this table. Geometric because deviations are ratios: half the price and twice the price average to 100%, not 125%.

Genscript Biotech: 13 of 13 models see the stock below the current price.

Vertex Pharmaceuticals: 19 of 24 models see the stock below the current price.

Scenario ranges

From our cautious bear scenario to the optimistic bull scenario. The white tick is the current price (value above it), the green tick the fair value (value below it): if the price sits left of the fair value, there is room to rise.

Genscript Biotech
Price HK$44.86
Fair Value HK$22.17
Bear HK$13.25Bull HK$41.60
Vertex Pharmaceuticals
Price $523
Fair Value $580
Bear $348Bull $1,257

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Ranked within their sector

Where each stock sits within its sector peer group. Band = middle 50% of peers, tick = median, dot = this stock.

Genscript Biotech · Health Care

Quality score55 · above median
Fair value upside−50.6% · below median

Vertex Pharmaceuticals · Health Care

Quality score80 · Top 25%
Fair value upside+11.0% · above median

Bottom line

As of Oct 1, 2026, Fair Value Calculator sees Vertex Pharmaceuticals as the more attractively valued of the two: Genscript Biotech trades at HK$44.86 versus a fair value of HK$22.17 (−50.6%), while Vertex Pharmaceuticals trades at $523 versus $580 (+11.0%).

Vertex Pharmaceuticals has the higher quality score (80/100).

Open Vertex Pharmaceuticals live analysis →

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A model-based valuation snapshot from 26 models. Values change with price and fundamentals; the date shown above applies.