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STOCK COMPARISON

Vertex Pharmaceuticals vs Wave Life Sciences: Fair Value & Quality

Both stocks run through our valuation models. Here is how Vertex Pharmaceuticals (VRTX) and Wave Life Sciences (WVE) compare, as of Sep 24, 2026.

As of Sep 24, 2026, Fair Value Calculator sees Vertex Pharmaceuticals as the more attractively valued of the two: Vertex Pharmaceuticals trades at $516 versus a fair value of $566 (+10%), while Wave Life Sciences trades at $3.95 versus $2.17 (-45%).
Vertex Pharmaceuticals
VRTX · USD · Health Care
+10%
upside to fair value
fairly valued
Price$516
Fair Value$566
Quality79/100
Wave Life Sciences
WVE · USD · Health Care
-45%
upside to fair value
overvalued
Price$3.95
Fair Value$2.17
Quality24/100
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Head-to-head numbers

Green is the better side of a row, red the weaker one (for valuation multiples: lower = cheaper). Grey rows are for reference only and are not scored.

betterweakerfor reference, not scored

Vertex PharmaceuticalsWave Life Sciences
Valuation
30.7×P/E (TTM)n/a
10.90×P/S (TTM)12.21×
7.14×P/B1.52×
25.8×EV/EBITDAn/a
1.72×PEGn/a
+9.7%Fair value upside−45.1%
Profitability
38%Operating marginn/a
0.86×EBIT margin trend (5Y)n/a
24%Return on equity-67%
12%Return on assets-34%
Growth
8%Revenue growth (YoY)-74%
10.6%Avg. growth/yr (3Y)n/a
14.2%Avg. growth/yr (5Y)16.3%
+13.5%Value creation/yrn/a
Balance & size
357.9×Interest coverage (EBIT/interest)n/a
0.03×Debt / equityn/a
$133BMarket cap$798M
healthyGrowth qualitymixed

Vertex Pharmaceuticals leads: 4 to 2 metric wins.

n/a = not meaningfully computable, for example with negative equity.

Quality in detail

The quality score, broken down into the same factor families as on the stock page, 0 to 100 per family.

Vertex Pharmaceuticalsof which business quality 77 · market factors 73 Wave Life Sciencesof which business quality 24 · market factors 18
ProfitabilityMargins and returns on capital today
72
2
Quality GrowthAre margins and returns improving?
65
1
CashflowEarnings quality: real cash, not paper profit
79
9
Fin. StrengthBalance sheet, leverage, solvency risk
92
80
InvestmentDisciplined investing over empire-building
58
50
Low VolatilityCalm price path (market factor)
85
50
MomentumPrice trend over the last 3–12 months (market factor)
65
6
52W MomentumDistance to the 52-week high (market factor)
75
0
Net IssuanceShare count: buybacks or dilution?
82
0

What the models say

How far the median fair value (base case) per model family sits from the current price, in percent. The amount in the currency of the trading venue is shown underneath.

above the price, more than 15% above close to the price, 85% to 115% of the price below the price, more than 15% below

Model familyVertex PharmaceuticalsPrice $516Wave Life SciencesPrice $3.95
DCF Models-12%close to the price$453n/a
Earnings-Based0%close to the price$516n/a
Multiples-46%below the price$278n/a
Asset-Based-90%below the price$49.27-55%below the price$1.79
Growth DCF-32%below the price$349n/a
Economic Profit-53%below the price$245n/a
Growth Earnings+34%above the price$692n/a
Minimum-90%below the price$49.27-55%below the price$1.79
Maximum+34%above the price$692-55%below the price$1.79
Median-32%below the price$349-55%below the price$1.79
Geometric mean-43%below the price$294-55%below the price$1.79

Minimum, maximum, median and geometric mean refer to the family values in this table. Geometric because deviations are ratios: half the price and twice the price average to 100%, not 125%.

Vertex Pharmaceuticals: 19 of 24 models see the stock below the current price.

Wave Life Sciences: 1 of 1 models see the stock below the current price.

Scenario ranges

From our cautious bear scenario to the optimistic bull scenario. The white tick is the current price (value above it), the green tick the fair value (value below it): if the price sits left of the fair value, there is room to rise.

Vertex Pharmaceuticals
Price $516
Fair Value $566
Bear $340Bull $1,226
Wave Life Sciences
Price $3.95
Fair Value $2.17
Bear $1.43Bull $2.71

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Ranked within their sector

Where each stock sits within its sector peer group. Band = middle 50% of peers, tick = median, dot = this stock.

Vertex Pharmaceuticals · Health Care

Quality score79 · Top 25%
Fair value upside+10% · above median

Wave Life Sciences · Health Care

Quality score24 · bottom 25%
Fair value upside-45% · below median

Bottom line

As of Sep 24, 2026, Fair Value Calculator sees Vertex Pharmaceuticals as the more attractively valued of the two: Vertex Pharmaceuticals trades at $516 versus a fair value of $566 (+10%), while Wave Life Sciences trades at $3.95 versus $2.17 (-45%).

Vertex Pharmaceuticals has the higher quality score (79/100).

Open Vertex Pharmaceuticals live analysis →

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A model-based valuation snapshot from 26 models. Values change with price and fundamentals; the date shown above applies.