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STOCK COMPARISON

Alnylam Pharmaceuticals vs Vertex Pharmaceuticals: Fair Value & Quality

Both stocks run through our valuation models. Here is how Alnylam Pharmaceuticals (ALNY) and Vertex Pharmaceuticals (VRTX) compare, as of Aug 8, 2026.

As of Aug 8, 2026, Fair Value Calculator sees Vertex Pharmaceuticals as the less overvalued of the two: Alnylam Pharmaceuticals trades at $216 versus a fair value of $51.70 (-76%), while Vertex Pharmaceuticals trades at $484 versus $279 (-42%).
Alnylam Pharmaceuticals
ALNY · USD · Health Care
-76%
upside to fair value
overvalued
Price$216
Fair Value$51.70
Quality53/100
Vertex Pharmaceuticals
VRTX · USD · Health Care
-42%
upside to fair value
overvalued
Price$484
Fair Value$279
Quality74/100

Head-to-head numbers

Green value = the better side for that row (for valuation multiples: lower = cheaper).

Alnylam PharmaceuticalsVertex Pharmaceuticals
Valuation
70.9×P/E (TTM)28.8×
8.33×P/S (TTM)10.06×
45.25×P/B6.59×
43.5×EV/EBITDA23.8×
0.51×PEG1.72×
Profitability
13%Net margin36%
23%Operating margin38%
90%Return on equity24%
10%Return on assets12%
Growth
96%Revenue growth (YoY)8%
53.0%Avg. growth/yr (3Y)10.6%
49.8%Avg. growth/yr (5Y)14.2%
Balance & size
1.28×Debt / equity0.03×
$36BMarket cap$123B
healthyGrowth qualityhealthy

Vertex Pharmaceuticals leads: 6 to 7 metric wins.

Dash = not meaningfully computable, for example with negative equity.

Quality in detail

The quality score, broken down into the same factor families as on the stock page, 0 to 100 per family.

Alnylam Pharmaceuticalsof which business quality 63 · market factors 23 Vertex Pharmaceuticalsof which business quality 77 · market factors 60
ProfitabilityMargins and returns on capital today
68
72
Quality GrowthAre margins and returns improving?
82
65
CashflowEarnings quality: real cash, not paper profit
70
79
Fin. StrengthBalance sheet, leverage, solvency risk
54
92
InvestmentDisciplined investing over empire-building
70
58
Low VolatilityCalm price path (market factor)
63
77
MomentumPrice trend over the last 3–12 months (market factor)
11
52
52W MomentumDistance to the 52-week high (market factor)
0
55
Net IssuanceBuybacks instead of dilution
36
82

What the models say

The median fair value (base case) per model family, each in the currency of its trading venue. Green = above the current price, red = below.

Alnylam Pharmaceuticals

DCF Models$96.21
Earnings-Based$82.25
Multiples$50.35
Asset-Based$3.96
Growth DCF$102
Economic Profit$37.29
Growth Earnings$106

24 of 24 models see the stock below the current price.

Vertex Pharmaceuticals

DCF Models$429
Earnings-Based$516
Dividend Discount$7.07
Multiples$246
Asset-Based$49.27
Growth DCF$333
Economic Profit$254
Growth Earnings$672

19 of 26 models see the stock below the current price.

Scenario ranges

From our cautious bear case to the optimistic bull case. The white tick is the current price: left of fair value means room to run.

Alnylam Pharmaceuticals
Bear $38.77Fair Value $51.70Bull $142
$216 = current price (white tick)
Vertex Pharmaceuticals
Bear $210Fair Value $279Bull $900
$484 = current price (white tick)

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Ranked within their sector

Where each stock sits within its sector peer group. Band = middle 50% of peers, tick = median, dot = this stock.

Alnylam Pharmaceuticals · Health Care

Quality score53 · above median
Fair value upside-76% · bottom 25%

Vertex Pharmaceuticals · Health Care

Quality score74 · Top 25%
Fair value upside-42% · below median

Bottom line

As of Aug 8, 2026, Fair Value Calculator sees Vertex Pharmaceuticals as the less overvalued of the two: Alnylam Pharmaceuticals trades at $216 versus a fair value of $51.70 (-76%), while Vertex Pharmaceuticals trades at $484 versus $279 (-42%).

Vertex Pharmaceuticals has the higher quality score (74/100).

See the full analysis →

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A model-based valuation snapshot from 21 models. Values change with price and fundamentals; the date shown above applies.