Alnylam Pharmaceuticals Inc (ALNY) fair value: what the stock is really worth
We calculate from audited financials what Alnylam Pharmaceuticals Inc is really worth. The fair value tells you whether the price is too high or too low, the quality score (0 to 100) how solid the business behind it is. 26 models, 37 quality factors, updated daily.
- Fair value above price? No
- Good quality? Yes
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Alnylam Pharmaceuticals Inc
ALNY · USOvervalued / MonitorQuality growthQuality is not strong enough to offset the price risk.
What runs behind every stock
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Price vs Fair Value
White line = price, green steps = our fair value per fiscal year, dashed = 300-day average. As of Sep 17, 2026.
How to read this chart
60‑month range $120.42 – $491.22 · fair‑value band $111.68 – $357.96 · the $239.56 price screens above the $211.88 fair value. Green steps = our fair value per fiscal year (point-in-time, no hindsight). Dashed = 300-day average. As of Sep 17, 2026.
Company profile
Alnylam Pharmaceuticals, Inc. discovers, develops, manufactures, and commercializes therapeutics based on ribonucleic acid interference in the United States, Europe, and internationally.
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Alnylam Pharmaceuticals, Inc. discovers, develops, manufactures, and commercializes therapeutics based on ribonucleic acid interference in the United States, Europe, and internationally. The company offers ONPATTRO for hereditary transthyretin-mediated (hATTR) amyloidosis; AMVUTTRA for ATTR and hATTR amyloidosis; Leqvio for hypercholesterolemia; Qfitlia for hemophilia A or B; GIVLAARI for acute hepatic porphyria; and OXLUMO for primary hyperoxaluria type 1. It also develops a range of products in Phase 3 trial, such as Nucresiran for ATTR amyloidosis; Zilebesiran for hypertension; Cemdisiran for myasthenia gravis, paroxysmal nocturnal hemoglobinuria, and geographic atrophy; and Elebsiran for hepatitis D virus infections. In addition, the company is developing various products in Phase 2 trial, including Rapirosiran for metabolic dysfunction-associated steatohepatitis; ALN-ANG3 for diabetic kidney disease; ALN-4324 for type 2 diabetes mellitus; Mivelsiran for cerebral amyloid angiopathy, as well as in Phase 1 trial for Alzheimer's disease; and ALN-6400 for bleeding disorders. Further, it develops a range of products in Phase 1 trial, such as ALN-2232 for obesity and weight management; ALN-PNP for non-alcoholic fatty liver disease; ALN-APOC3 for dyslipidemia; ALN-CIDEB for metabolic dysfunction-associated steatohepatitis; ALN-HTT02 for Huntington's disease; ALN-5288 for Alzheimer's disease; ALN-SOD for SOD1 amyotrophic lateral sclerosis; ALN-SNCA for Parkinson's disease; AG-236 for polycythemia vera; ALN-CFB for paroxysmal nocturnal hemoglobinuria; ALN-BCAT for hepatocellular carcinoma; and ALN-4285, ALN-4915, and ALN-F1202 for healthy volunteers. The company has collaborations with Regeneron Pharmaceuticals, Inc.; Roche Holding AG; Sanofi S.A.; Novartis AG; PeptiDream, Inc; Dicerna Pharmaceuticals, Inc.; and Ionis Pharmaceuticals, Inc. Alnylam Pharmaceuticals, Inc. was founded in 2002 and is headquartered in Cambridge, Massachusetts.
Stock analysis
Alnylam Pharmaceuticals Inc (ALNY) currently trades at $239.56, while our model-based Fair Value estimate is $211.88, implying the stock looks roughly 13.1% overvalued today.
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Valuation
Bull case: the Growth Earnings group reads highest at a median of $109.18 per share, and 0 of the 24 models we run sit above the $239.56 price.
Bear case: the Economic Profit group reads lowest at $28.08, and 24 of the 24 models stay below the price. Evidence for this calculation is low.
Scenario range: $111.68 (bear) to $357.96 (bull), the price of $239.56 sits inside it. Bear and bull are the same models on cautious and optimistic assumptions, a range, not a price target.
Quality & growth
The Quality Score stands at 66/100 (solid quality), in the Healthcare sector.
Healthy Growth: Revenue growth appears healthy and is supported by profitability and cash-flow quality.
Alnylam Pharmaceuticals Inc reported revenue of $3.7B in FY2025 versus $844M in FY2021, a compound +44.8%/yr. Reported net income was $314M in FY2025.
Key figures
Market cap $35.7B · P/E ratio 60.2 · P/S ratio 5.08 · EPS (TTM) $3.98 · Net margin 8.4% · Return on equity 90.4% · Return on assets (EBIT) −8.6% · Operating margin 23.0%.
Competitive moat
Our AI-assisted moat analysis scores the competitive advantage at 58 out of 100 (medium confidence).
What moves the price
The last reported earnings sit well below what analysts expect (earnings in transition, for example after write-downs or an earnings dip); whether the stock is cheap or expensive hinges on the expected recovery actually arriving. Read the fair value with that caveat.
The share trades about 52% below its 52-week high, currently below its 200-day average.
For context, the median of 10 Healthcare peers we cover trades at 10% fair-value upside, at −12%, ALNY screens richer than that median.
Fair Value models
All 24 models by family
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Set up alert →Quality Score breakdown
Of which business quality 63 · Market factors (momentum, volatility) 24
Revenue & earnings trend
Growth Forecast
ALNY screens 13% overvalued. Compare with Vertex Pharmaceuticals Incorporated →
Recent news
- Is Alnylam (ALNY) Quietly Repricing Its RNAi Risk Profile Amid Oligonucleotide Market Optimism?
- Oligonucleotide Therapeutics Market Outlook 2026-2035 - Featuring Profiles of Alnylam Pharmaceuticals, Ionis Pharmaceuticals, and Sarepta Th
- Alnylam's Sell-Off Looks Ugly -- but Wall Street Still Sees a Much Brighter Picture
- Here’s Why Alnylam Pharmaceuticals (ALNY) Declined
Compare Alnylam Pharmaceuticals Inc with another stock
Price, fair value, quality and upside side by side.
Peer GroupⓘHow this stock ranks against its industry: the green marker is this stock, the band is the typical 25–75% peer range, and the tick is the median.Biotechnology · 652 stocks
Valuation Multiplesvs Biotechnology median · lower = cheaper
Strength profile in five axes (Snowflake)
Context: sector, industry, market
- Is the Health Care sector expensive or cheap?
- P/E, EV/EBITDA and margins by industry (reference tables)
- Undervalued stocks: US Stocks
- Valuation of the USA market
Values & ESG
Does this company touch areas you may want to avoid? The classification is inferred from sector and industry.
Similar stocks
10 more Biotechnology stocks, each showing price versus our Fair Value estimate.
| Stock | Price | Fair Value | vs Fair Value |
|---|---|---|---|
| Vertex Pharmaceuticals Incorporated VRTX | $514.63 | $566.09 | +10% |
| Regeneron Pharmaceuticals, Inc REGN | $774.11 | $1,241 | +60% |
| argenx SE ARGX | $984.69 | $917.18 | −7% |
| BeOne Medicines AG 688235 | ¥247.30 | ¥124.62 | −50% |
| Samsung Biologics Co 207940 | 1,396,000 KRW | 1,535,600 KRW | +10% |
| CSL Limited CSL | A$174.41 | A$191.85 | +10% |
| Royalty Pharma plc RPRX | $58.47 | $24.22 | −59% |
| Celltrion, Inc 068270 | 180,300 KRW | 74,519 KRW | −59% |
| BioNTech SE BNTX | $96.69 | $62.63 | −35% |
| Incyte Corporation INCY | $124.75 | $204.93 | +64% |
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Key figures of Alnylam Pharmaceuticals Inc
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