EN DE
STOCK COMPARISON

AN2 Therapeutics vs Vertex Pharmaceuticals: Fair Value & Quality

Both stocks run through our valuation models. Here is how AN2 Therapeutics (ANTX) and Vertex Pharmaceuticals (VRTX) compare, as of Sep 25, 2026.

As of Sep 25, 2026, Fair Value Calculator sees Vertex Pharmaceuticals as the more attractively valued of the two: AN2 Therapeutics trades at $4.83 versus a fair value of $1.15 (-76%), while Vertex Pharmaceuticals trades at $516 versus $568 (+10%).
AN2 Therapeutics
ANTX · USD · Health Care
-76%
upside to fair value
overvalued
Price$4.83
Fair Value$1.15
Quality50/100
Vertex Pharmaceuticals
VRTX · USD · Health Care
+10%
upside to fair value
fairly valued
Price$516
Fair Value$568
Quality79/100
Get comparisons like this free by email every month: the most undervalued quality stocks.

Head-to-head numbers

Green is the better side of a row, red the weaker one (for valuation multiples: lower = cheaper). Grey rows are for reference only and are not scored.

betterweakerfor reference, not scored

AN2 TherapeuticsVertex Pharmaceuticals
Valuation
n/aP/E (TTM)30.7×
n/aP/E ex one-offs (FY2025)30.7×
n/aP/S (TTM)10.90×
4.07×P/B7.14×
n/aEV/EBITDA25.8×
n/aPEG1.72×
−76.2%Fair value upside+10.0%
Profitability
0%Operating margin38%
n/aEBIT margin trend (5Y)0.86×
-50%Return on equity24%
-31%Return on assets12%
Growth
0%Revenue growth (YoY)8%
n/aAvg. growth/yr (3Y)10.6%
n/aAvg. growth/yr (5Y)14.2%
n/aValue creation/yr+13.5%
Balance & size
n/aInterest coverage (EBIT/interest)357.9×
n/aDebt / equity0.03×
$216MMarket cap$133B
n/aGrowth qualityhealthy
The P/E excluding one-off items is only shown where the special items are documented in the accounts (our own raw data or SEC filings). If one side lacks it, the reported P/E stays scored.

Vertex Pharmaceuticals leads: 1 to 3 metric wins.

n/a = not meaningfully computable, for example with negative equity.

Quality in detail

The quality score, broken down into the same factor families as on the stock page, 0 to 100 per family.

AN2 Therapeuticsof which business quality 50 · market factors 69 Vertex Pharmaceuticalsof which business quality 78 · market factors 75
ProfitabilityMargins and returns on capital today
0
72
Quality GrowthAre margins and returns improving?
45
65
CashflowEarnings quality: real cash, not paper profit
62
79
Fin. StrengthBalance sheet, leverage, solvency risk
100
92
InvestmentDisciplined investing over empire-building
100
58
Low VolatilityCalm price path (market factor)
50
85
MomentumPrice trend over the last 3–12 months (market factor)
71
66
52W MomentumDistance to the 52-week high (market factor)
86
78
Net IssuanceShare count: buybacks or dilution?
0
89

What the models say

How far the median fair value (base case) per model family sits from the current price, in percent. The amount in the currency of the trading venue is shown underneath.

above the price, more than 15% above close to the price, 85% to 115% of the price below the price, more than 15% below

Model familyAN2 TherapeuticsPrice $4.83Vertex PharmaceuticalsPrice $516
DCF Modelsn/a-12%close to the price$454
Earnings-Basedn/a0%close to the price$517
Multiplesn/a-46%below the price$279
Asset-Based-81%below the price$0.94-90%below the price$49.34
Growth DCFn/a-32%below the price$349
Economic Profitn/a-53%below the price$245
Growth Earningsn/a+34%above the price$693
Minimum-81%below the price$0.94-90%below the price$49.34
Maximum-81%below the price$0.94+34%above the price$693
Median-81%below the price$0.94-32%below the price$349
Geometric mean-81%below the price$0.94-43%below the price$294

Minimum, maximum, median and geometric mean refer to the family values in this table. Geometric because deviations are ratios: half the price and twice the price average to 100%, not 125%.

AN2 Therapeutics: 1 of 1 models see the stock below the current price.

Vertex Pharmaceuticals: 17 of 24 models see the stock below the current price.

Scenario ranges

From our cautious bear scenario to the optimistic bull scenario. The white tick is the current price (value above it), the green tick the fair value (value below it): if the price sits left of the fair value, there is room to rise.

AN2 Therapeutics
Price $4.83
Fair Value $1.15
Bear $0.76Bull $1.44
Vertex Pharmaceuticals
Price $516
Fair Value $568
Bear $341Bull $1,230

Compare two other stocks

Tap a field and type again, ticker or company name.

Free, no sign-up

Ranked within their sector

Where each stock sits within its sector peer group. Band = middle 50% of peers, tick = median, dot = this stock.

AN2 Therapeutics · Health Care

Quality score50 · below median
Fair value upside-76% · bottom 25%

Vertex Pharmaceuticals · Health Care

Quality score79 · Top 25%
Fair value upside+10% · above median

Bottom line

As of Sep 25, 2026, Fair Value Calculator sees Vertex Pharmaceuticals as the more attractively valued of the two: AN2 Therapeutics trades at $4.83 versus a fair value of $1.15 (-76%), while Vertex Pharmaceuticals trades at $516 versus $568 (+10%).

Vertex Pharmaceuticals has the higher quality score (79/100).

Open Vertex Pharmaceuticals live analysis →

More comparisons

Popular match-ups from the same sectors, all with fair value and quality score.

Free · Top-25 report

See the undervalued quality stocks every month

Just your email for the monthly Top-25 report of the most undervalued quality stocks, with fair value, quality and price target. Plus 14 days of Pro to try, no card.

Free. You confirm by email (double opt-in) and can unsubscribe anytime in one click. Not financial advice.

A model-based valuation snapshot from 26 models. Values change with price and fundamentals; the date shown above applies.