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STOCK COMPARISON

CARsgen Therapeutics Holdings vs Vertex Pharmaceuticals: Fair Value & Quality

Both stocks run through our valuation models. Here is how CARsgen Therapeutics Holdings (CRTHF) and Vertex Pharmaceuticals (VRTX) compare, as of Sep 14, 2026.

As of Sep 14, 2026, Fair Value Calculator sees Vertex Pharmaceuticals as the more attractively valued of the two: CARsgen Therapeutics Holdings trades at $1.62 versus a fair value of $0.37 (-77%), while Vertex Pharmaceuticals trades at $515 versus $567 (+10%).
CARsgen Therapeutics Holdings
CRTHF · USD · Health Care
-77%
upside to fair value
overvalued
Price$1.62
Fair Value$0.37
Quality60/100
Vertex Pharmaceuticals
VRTX · USD · Health Care
+10%
upside to fair value
fairly valued
Price$515
Fair Value$567
Quality79/100
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Head-to-head numbers

Green value = the better side for that row (for valuation multiples: lower = cheaper).

CARsgen Therapeutics HoldingsVertex Pharmaceuticals
Valuation
P/E (TTM)28.8×
9.08×P/S (TTM)10.06×
1.46×P/B6.59×
EV/EBITDA23.8×
PEG1.72×
−77.2%Fair value upside+10.0%
7.4%Dividend yield0.1%
Profitability
-116%Operating margin38%
EBIT margin trend (5Y)0.86×
-11%Return on equity24%
-10%Return on assets12%
Growth
126%Revenue growth (YoY)8%
Avg. growth/yr (3Y)10.6%
Avg. growth/yr (5Y)14.2%
Value creation/yr+13.6%
Balance & size
Interest coverage (EBIT/interest)357.9×
Debt / equity0.03×
$1BMarket cap$123B
mixedGrowth qualityhealthy

Vertex Pharmaceuticals leads: 3 to 4 metric wins.

Dash = not meaningfully computable, for example with negative equity.

Quality in detail

The quality score, broken down into the same factor families as on the stock page, 0 to 100 per family.

CARsgen Therapeutics Holdingsof which business quality 58 · market factors 61 Vertex Pharmaceuticalsof which business quality 77 · market factors 74
ProfitabilityMargins and returns on capital today
2
72
Quality GrowthAre margins and returns improving?
97
65
CashflowEarnings quality: real cash, not paper profit
33
79
Fin. StrengthBalance sheet, leverage, solvency risk
73
92
InvestmentDisciplined investing over empire-building
95
58
Low VolatilityCalm price path (market factor)
50
85
MomentumPrice trend over the last 3–12 months (market factor)
58
63
52W MomentumDistance to the 52-week high (market factor)
80
80
Net IssuanceShare count: buybacks or dilution?
87
82

What the models say

How far the median fair value (base case) per model family sits from the current price, in percent. The amount in the currency of the trading venue is shown underneath.

above the price, more than 15% above close to the price, 85% to 115% of the price below the price, more than 15% below

Model familyCARsgen Therapeutics HoldingsPrice $1.62Vertex PharmaceuticalsPrice $515
DCF Modelsn/a-12%close to the price$453
Earnings-Basedn/a0%close to the price$516
Dividend Discount+23%above the price$1.99-99%below the price$7.07
Multiplesn/a-46%below the price$278
Asset-Based-43%below the price$0.92-90%below the price$49.27
Growth DCFn/a-32%below the price$348
Economic Profitn/a-51%below the price$254
Growth Earningsn/a+34%above the price$692
Minimum-43%below the price$0.92-99%below the price$7.07
Maximum+23%above the price$1.99+34%above the price$692
Median-10%close to the price$1.46-39%below the price$313
Geometric mean-16%below the price$1.35-64%below the price$185

Minimum, maximum, median and geometric mean refer to the family values in this table. Geometric because deviations are ratios: half the price and twice the price average to 100%, not 125%.

CARsgen Therapeutics Holdings: 1 of 3 models see the stock below the current price.

Vertex Pharmaceuticals: 19 of 26 models see the stock below the current price.

Scenario ranges

From our cautious bear scenario to the optimistic bull scenario. The white tick is the current price (value above it), the green tick the fair value (value below it): if the price sits left of the fair value, there is room to rise.

CARsgen Therapeutics Holdings
Price $1.62
Fair Value $0.37
Bear $0.19Bull $0.54
Vertex Pharmaceuticals
Price $515
Fair Value $567
Bear $330Bull $1,264

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Ranked within their sector

Where each stock sits within its sector peer group. Band = middle 50% of peers, tick = median, dot = this stock.

CARsgen Therapeutics Holdings · Health Care

Quality score60 · above median
Fair value upside-77% · bottom 25%

Vertex Pharmaceuticals · Health Care

Quality score79 · Top 25%
Fair value upside+10% · above median

Bottom line

As of Sep 14, 2026, Fair Value Calculator sees Vertex Pharmaceuticals as the more attractively valued of the two: CARsgen Therapeutics Holdings trades at $1.62 versus a fair value of $0.37 (-77%), while Vertex Pharmaceuticals trades at $515 versus $567 (+10%).

Vertex Pharmaceuticals has the higher quality score (79/100).

See the full analysis →

More comparisons

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A model-based valuation snapshot from 26 models. Values change with price and fundamentals; the date shown above applies.