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STOCK COMPARISON

Royalty Pharma Plc vs Vertex Pharmaceuticals: Fair Value & Quality

Both stocks run through our valuation models. Here is how Royalty Pharma Plc (RPRX) and Vertex Pharmaceuticals (VRTX) compare, as of Aug 8, 2026.

As of Aug 8, 2026, Fair Value Calculator sees Vertex Pharmaceuticals as the less overvalued of the two: Royalty Pharma Plc trades at $57.26 versus a fair value of $24.22 (-58%), while Vertex Pharmaceuticals trades at $484 versus $279 (-42%).
Royalty Pharma Plc
RPRX · USD · Health Care
-58%
upside to fair value
overvalued
Price$57.26
Fair Value$24.22
Quality77/100
Vertex Pharmaceuticals
VRTX · USD · Health Care
-42%
upside to fair value
overvalued
Price$484
Fair Value$279
Quality74/100

Head-to-head numbers

Green value = the better side for that row (for valuation multiples: lower = cheaper).

Royalty Pharma PlcVertex Pharmaceuticals
Valuation
30.6×P/E (TTM)28.8×
13.73×P/S (TTM)10.06×
5.17×P/B6.59×
26.5×EV/EBITDA23.8×
2.18×PEG1.72×
1.5%Dividend yield
$0.90Dividend per share
Profitability
34%Net margin36%
100%Operating margin38%
14%Return on equity24%
6%Return on assets12%
Growth
11%Revenue growth (YoY)8%
2.1%Avg. growth/yr (3Y)10.6%
2.3%Avg. growth/yr (5Y)14.2%
Balance & size
1.32×Debt / equity0.03×
$34BMarket cap$123B
mixedGrowth qualityhealthy

Vertex Pharmaceuticals leads: 3 to 10 metric wins.

Dash = not meaningfully computable, for example with negative equity.

Quality in detail

The quality score, broken down into the same factor families as on the stock page, 0 to 100 per family.

Royalty Pharma Plcof which business quality 66 · market factors 88 Vertex Pharmaceuticalsof which business quality 77 · market factors 60
ProfitabilityMargins and returns on capital today
42
72
Quality GrowthAre margins and returns improving?
45
65
CashflowEarnings quality: real cash, not paper profit
100
79
Fin. StrengthBalance sheet, leverage, solvency risk
41
92
InvestmentDisciplined investing over empire-building
83
58
Low VolatilityCalm price path (market factor)
91
77
MomentumPrice trend over the last 3–12 months (market factor)
83
52
52W MomentumDistance to the 52-week high (market factor)
95
55
Net IssuanceBuybacks instead of dilution
93
82

What the models say

The median fair value (base case) per model family, each in the currency of its trading venue. Green = above the current price, red = below.

Royalty Pharma Plc

DCF Models$53.92
Earnings-Based$48.22
Dividend Discount$11.89
Multiples$23.42
Asset-Based$7.75
Growth DCF$126
Economic Profit$9.18
Growth Earnings$62.13

17 of 23 models see the stock below the current price.

Vertex Pharmaceuticals

DCF Models$429
Earnings-Based$516
Dividend Discount$7.07
Multiples$246
Asset-Based$49.27
Growth DCF$333
Economic Profit$254
Growth Earnings$672

19 of 26 models see the stock below the current price.

Scenario ranges

From our cautious bear case to the optimistic bull case. The white tick is the current price: left of fair value means room to run.

Royalty Pharma Plc
Bear $17.57Fair Value $24.22Bull $34.00
$57.26 = current price (white tick)
Vertex Pharmaceuticals
Bear $210Fair Value $279Bull $900
$484 = current price (white tick)

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Ranked within their sector

Where each stock sits within its sector peer group. Band = middle 50% of peers, tick = median, dot = this stock.

Royalty Pharma Plc · Health Care

Quality score77 · Top 25%
Fair value upside-58% · below median

Vertex Pharmaceuticals · Health Care

Quality score74 · Top 25%
Fair value upside-42% · below median

Bottom line

As of Aug 8, 2026, Fair Value Calculator sees Vertex Pharmaceuticals as the less overvalued of the two: Royalty Pharma Plc trades at $57.26 versus a fair value of $24.22 (-58%), while Vertex Pharmaceuticals trades at $484 versus $279 (-42%).

Royalty Pharma Plc has the higher quality score (77/100).

See the full analysis →

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A model-based valuation snapshot from 21 models. Values change with price and fundamentals; the date shown above applies.