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STOCK COMPARISON

Amgen vs AstraZeneca: Fair Value & Quality

Both stocks run through our valuation models. Here is how Amgen (AMGN) and AstraZeneca (AZN) compare, as of Oct 30, 2026.

As of Oct 30, 2026, Fair Value Calculator sees Amgen as the more attractively valued of the two: Amgen trades at $466 versus a fair value of $513 (+10.0%), while AstraZeneca trades at £140 versus £94.94 (−32.0%).
Amgen
AMGN · USD · Health Care
+10.0%
upside to fair value
undervalued
Price$466
Fair Value$513
Quality64/100
Fair ValueQualityUptrend
AstraZeneca
AZN.LSE · GBP · Health Care
−32.0%
upside to fair value
overvalued
Price£140
Fair Value£94.94
Quality70/100
Fair ValueQualityUptrend
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Head-to-head numbers

Green is the better side of a row, red the weaker one (for valuation multiples: lower = cheaper). Grey rows are for reference only and are not scored.

betterweakerfor reference, not scored

AmgenAstraZeneca
Valuation
28.9×P/E (TTM)28.0×
38.2×P/E ex one-offs (FY2025)28.0×
19.0×Forward P/E (FY2027)16.4×
21.8×Median P/E at FY-end (10 FY, ex one-offs where documented)n/a
6.66×P/S (TTM)4.68×
29.28× · book value is mostly goodwillP/B6.00× · book value is mostly goodwill
17.1×EV/EBITDA14.6×
2.45×PEG1.32×
+10.0%Fair value upside−32.0%
2.1%Dividend yield1.7%
$9.80Dividend per share£2.39
Profitability
35.6%Operating margin29.6%
0.81×EBIT margin trend (5Y)1.38×
91.5%Return on equity22.6%
8.5%Return on assets9.0%
Growth
9.5%Revenue growth (YoY)6.7%
11.8%Avg. growth/yr (3Y)9.9%
7.6%Avg. growth/yr (5Y)14.9%
+1.9%Value creation/yr+46.5%
Balance & size
3.9×Interest coverage (EBIT/interest)8.1×
5.78×Debt / equity0.51×
$254BMarket cap$292B
healthyGrowth qualityhealthy
The P/E excluding one-off items is scored. For AstraZeneca no documented adjusted P/E is available, so its reported P/E is shown there. The trailing P/E is shown for reference.
Amgen, median P/E at fiscal year-end, 10 fiscal years (2016 to 2025), reported earnings, FY2017, FY2024, FY2025 ex one-offs: 21.8.
Forward P/E: price divided by the analyst consensus for the first fiscal year that has not started yet. The current year carries special items from quarters already reported.

AstraZeneca leads: 4 to 10 metric wins.

n/a = not meaningfully computable, for example with negative equity.

Quality in detail

The quality score, broken down into the same factor families as on the stock page, 0 to 100 per family.

Amgen AstraZeneca
ProfitabilityHow much profit the company makes from its sales and capital
64
63
Quality GrowthAre margins and returns getting better?
79
76
CashflowDo the profits arrive as real cash?
78
63
Financial strengthDebt, balance sheet and risk of trouble
23
63
InvestmentDoes it invest with discipline instead of growing at any price?
42
60
Low VolatilityHow calm the share price moves, does not count
84
86
Price momentumPrice momentum of the last 3 to 12 months, does not count
87
51
Near the 52-week highDistance to the 52-week high, does not count
100
56
New sharesBuys back shares or issues new ones?
78
83

What the models say

How far the median fair value (base case) per model family sits from the current price, in percent. The amount in the currency of the trading venue is shown underneath.

above the price, more than 15% above close to the price, 85% to 115% of the price below the price, more than 15% below

Model familyAmgenPrice $466AstraZenecaPrice £140
DCF Models−19.5%below the price$375−33.3%below the price£93.18
Earnings-Based−67.5%below the price$152−67.4%below the price£45.54
Dividend Discount−54.4%below the price$213−66.0%below the price£47.47
Multiples−46.0%below the price$252−27.8%below the price£101
Growth DCF−26.5%below the price$342−38.8%below the price£85.49
Economic Profit−65.8%below the price$159−59.6%below the price£56.43
Growth Earnings−44.1%below the price$261−32.0%below the price£94.94
Matching families7 of 7
Minimum−67.5%below the price$152−67.4%below the price£45.54
Maximum−19.5%below the price$375−27.8%below the price£101
Median−46.0%below the price$252−38.8%below the price£85.49
Geometric mean−48.9%below the price$238−49.0%below the price£71.22
Ahead family by family3 of 74 of 7

Minimum, maximum, median and geometric mean only use the families both stocks have (matching families: 7 of 7), so a family without a value on one side does not distort the comparison. Ahead in a family is the stock whose fair value there sits higher relative to its price. Geometric because deviations are ratios: half the price and twice the price average to 100%, not 125%.

Family by family: AstraZeneca is ahead in 4 of 7 shared families, Amgen in 3.

Amgen: 23 of 24 models see the stock below the current price.

AstraZeneca: 24 of 24 models see the stock below the current price.

Scenario ranges

From our cautious bear scenario to the optimistic bull scenario. The white tick is the current price (value above it), the green tick the fair value (value below it): if the price sits left of the fair value, there is room to rise.

Amgen
Price $466
Fair Value $513
Bear $351Bull $666
AstraZeneca
Price £140
Fair Value £94.94
Bear £56.13Bull £129

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Ranked within their sector

Where each stock sits within its sector peer group. Band = middle 50% of peers, tick = median, dot = this stock.

Amgen · Health Care

Quality score64 · above median
Fair value upside+10.0% · above median

AstraZeneca · Health Care

Quality score70 · Top 25%
Fair value upside−32.0% · below median

Bottom line

As of Oct 30, 2026, Fair Value Calculator sees Amgen as the more attractively valued of the two: Amgen trades at $466 versus a fair value of $513 (+10.0%), while AstraZeneca trades at £140 versus £94.94 (−32.0%).

AstraZeneca has the higher quality score (70/100).

Open Amgen live analysis →

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A model-based valuation snapshot from 26 models. Values change with price and fundamentals; the date shown above applies.