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Aprea Therapeutics Inc (APRE) fair value: what the stock is really worth

As of Oct 2, 2026: fair value of Aprea Therapeutics Inc $0.82, price $0.70, upside +17.4%, quality 32 out of 100. Calculated from audited financials with 26 valuation models and 37 quality factors, updated daily.

  1. Fair value above price? Yes
  2. Good quality? No
  3. Add to watchlist

Healthcare · US · ISIN US03836J2015

AT Aprea Therapeutics Inc logo Thin data Sep 27, 2026

Aprea Therapeutics Inc

APRE · US

SpeculativeUpside exists, but weak quality makes the signal speculative.

✓Fair value $0.8160 · Undervalued (+17.4%)
!Quality 32/100
!Weak Growth (revenue YoY −81.0 %/yr)
!Low debt · negative free cash flow
!Mixed vs. peers (3/7)
!Narrow moat 6/100
!Insider activity 35/100
!Evidence only low, so the estimate is less certain
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What runs behind every stock

26 valuation models 8 families, DCF to NCAV 37 quality factors margins, balance sheet, cashflow, debt 6 AI factors moat, what no ratio measures 2,000+ data points verified, per stock, median

69 individual criteria per stock, every one traceable See the method →

Price vs Fair Value

$112.60 $0.5900 Fair Value $0.8160 Jun 2021 Oct 2026

White line = price, green steps = our fair value per fiscal year, dashed = 300-day average. As of Sep 27, 2026.

How to read this chart

60‑month range $0.5900 – $112.60 · fair‑value band $0.5355 – $1.02 · the $0.6950 price screens below the $0.8160 fair value. Green steps = our fair value per fiscal year (point-in-time, no hindsight). Dashed = 300-day average. As of Sep 27, 2026.

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Company profile

Aprea Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing and commercializing novel synthetic lethality-based cancer therapeutics that targets DNA damage response pathways.

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Aprea Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing and commercializing novel synthetic lethality-based cancer therapeutics that targets DNA damage response pathways. Its lead product candidates are APR-1051, an orally bioavailable small-molecule inhibitor of WEE1 kinase that is in Phase 1 clinical trial for the treatment of patients with advanced solid tumors with biomarkers and ATRN-119, an ATR inhibitor, which is in Phase 1/2a clinical trial for solid tumor indications. The company is headquartered in Doylestown, Pennsylvania.

Stock analysis

Aprea Therapeutics Inc (APRE) currently trades at $0.6950, while our model-based Fair Value estimate is $0.8160, implying the stock looks roughly 14.8% undervalued today.

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Valuation

How firm this estimate is: it rests on 1 models at a data quality of 96/100, which puts the evidence level at low.

Scenario range: $0.5355 (bear) to $1.02 (bull), the price of $0.6950 sits inside it. Bear and bull are the same models on cautious and optimistic assumptions, a range, not a price target.

Quality & growth

The Quality Score stands at 32/100 (below-average quality), in the Healthcare sector.

Weak Growth: Revenue growth is weak, negative or inconsistent.

Aprea Therapeutics Inc reported revenue of $286K in FY2025 versus $0 in FY2021. Reported net income was −$12.6M in FY2025.

Key figures

Market cap $9.7M · EPS (TTM) $−0.9400 · Return on equity −46.2% · Return on assets (EBIT) −131% · Operating margin −255,026% · Revenue growth (YoY) −98.4% · Free cash flow −$12.9M · Net cash $14.6M.

Competitive moat

Our AI-assisted moat analysis scores the competitive advantage at 28 out of 100 (low confidence).

What moves the price

The share trades about 58% below its 52-week high and 18% above its 52-week low, currently below its 200-day average.

For context, the median of 10 Healthcare peers we cover trades at 10% fair-value upside, at 17%, APRE screens cheaper than that median.

Fair Value models

Bear $0.5355 Fair Value $0.8160 Bull $1.02
Model ⓘEach model values the company its own way (discounted cash flow, earnings, assets, dividends). The fair value above is their evidence-weighted blend, not the output of a single model. Bear ⓘBear = the cautious scenario: the same model computed with conservative anchors (lower growth, margins and valuation multiples). Together with Bull it frames a plausible valuation range, not a price target.BaseBull ⓘBull = the optimistic scenario: the same model computed with favourable anchors (higher growth, margins and valuation multiples). Together with Bear it frames a plausible valuation range, not a price target. If a model's bull case is above four times its base value, the table shows that limit with a > sign (like the overall Bull above): beyond it no assumption holds. Evidence ⓘEvidence = how well-backed THIS model's estimate is for this stock (0–100): how complete and reliable its input data are, and how well the model fits the company. The final Fair Value is an evidence-weighted blend, so better-evidenced models count more. Green ≥70, amber 50–69, grey below 50.
Highest evidence
NCAV (Graham) $0.4900 $0.6600 $0.9900 54
All 1 models by family
Asset-Based
NCAV (Graham) $0.4900 $0.6600 $0.9900 54

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Quality Score breakdown

Overall quality 32/100

Of which business quality 37 · Market factors (momentum, volatility) 14

Profitability 1
Margins and returns on capital today
Quality Growth 26
Are margins and returns improving?
Cashflow 34
Earnings quality: real cash, not paper profit
Fin. Strength 75
Balance sheet, leverage, solvency risk
Investment 100
Disciplined investing over empire-building
Low Volatility 7
Calm price path (market factor)
Momentum 25
Price trend over the last 3–12 months (market factor)
52W Momentum 5
Distance to the 52-week high (market factor)
Net Issuance 0
Share count: buybacks or dilution?

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Revenue & earnings trend

Growth Quality ⓘGrowth is valuable only when reinvestment earns attractive returns (Aswath Damodaran): sustainable growth depends on return on capital, reinvestment and efficiency. Basis: total company revenue over the periods shown on the cards (3Y/5Y/all years), not per share, so a merger can show up as a growth jump; per-share earnings growth is in the value-creation card. 0/100
Revenue growth is weak, negative or inconsistent.
Revenue growth 1 year
−81.0%
Revenue growth 18 years ⓘMeasures the company's TOTAL revenue from reported annual statements: compound average growth per year (CAGR) from the fiscal year 3, 5 or N years back to the most recent comparable fiscal year. Not per share: buybacks do not change this number, and a merger can appear as a growth jump. Per-share growth (which does include buybacks) is in the value-creation card.
+8.3%
Profit margin (trend) ⓘOperating margin then vs now, from reported annual statements. A falling margin after a boom year is the classic peak-earnings signal: the growth rate then leans on an inflated base.
−4,670.1% (2007) → −4,631.1% (2025)
What shareholders gained per year ⓘWe only publish this rate when it is defensible. Reason: fiscal 2025 is a loss year, no rate is defined from a loss
not computed

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Peer GroupⓘHow this stock ranks against its industry: the green marker is this stock, the band is the typical 25–75% peer range, and the tick is the median.Biotechnology · 576 stocks

Beats the industry median on 2/5 measures
A mixed picture versus its industry peers.
Valuation
Quality Score 37 · Below median
Fair Value upside +12.8% · Top 25%
Profitability
Return on assets −27.7% · Below median
Growth and dividend
Revenue growth −98.4% · Bottom 25%

Valuation Multiplesvs Biotechnology median · lower = cheaper

P/B 0.78× · Cheaper than median

Strength profile in five axes (Snowflake)

VALUEFUTUREPASTHEALTHDIVIDEND
This stock
VALUEFUTUREPASTHEALTHDIVIDEND
Sector peers
VALUE (fair-value potential)50 · sector 0
FUTURE (revenue growth)0 · sector 0
PAST (return on equity)0 · sector 0
HEALTH (low debt)100 · sector 97
DIVIDEND (yield)0 · sector 22

Context: sector, industry, market

Values & ESG

Does this company touch areas you may want to avoid? The classification is inferred from sector and industry.

None of the checked exposures detected

Similar stocks

10 more Biotechnology stocks, each showing price versus our Fair Value estimate.

Stock Price Fair Value vs Fair Value
Vertex Pharmaceuticals Incorporated VRTX $527.67 $580.44 +10%
Regeneron Pharmaceuticals, Inc REGN $752.25 $1,275 +69%
argenx SE ARGX $959.49 $918.60 −4%
CSL Limited CSL A$175.35 A$192.89 +10%
Samsung Biologics Co 207940 1,354,000 KRW 1,489,400 KRW +10%
BeOne Medicines AG ONC $360.85 $280.94 −22%
Alnylam Pharmaceuticals, Inc ALNY $255.96 $217.88 −15%
Royalty Pharma plc RPRX $58.21 $19.01 −67%
Celltrion, Inc 068270 177,400 KRW 74,519 KRW −58%
WuXi Biologics (Cayman) Inc 2269 HK$53.00 HK$58.30 +10%

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Aprea Therapeutics Inc · Fair Value
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Cite: Fair Value Calculator (2026). "Aprea Therapeutics Inc Fair Value". https://www.fairvalue-calculator.com/stock/APRE

Frequently asked questions

Is Aprea Therapeutics Inc (APRE) overvalued or undervalued?
As of Sep 27, 2026, our model estimates a fair value of $0.8160 versus a price of $0.6950, about +17% upside (undervalued).
What is the fair value of APRE?
Our model-based fair value for Aprea Therapeutics Inc is $0.8160 (as of Sep 27, 2026), built from audited fundamentals. The current price: $0.6950.
What is the quality score of APRE?
Aprea Therapeutics Inc has a Quality Score of 32/100. It measures business quality (profitability, growth, cash flow, balance-sheet strength, investment discipline, share issuance). Market factors such as price momentum and volatility do not enter the number; they are shown separately in the detail view.
What is the price target for Aprea Therapeutics Inc (APRE)?
Our model-based price target is the fair value of $0.8160 (as of Sep 27, 2026) from 1 valuation models. Cautious scenario $0.5355, optimistic scenario $1.02. It is a calculation from audited fundamentals, not an analyst target.
What is the Aprea Therapeutics Inc stock forecast for 2026?
Our models put fair value at $0.8160, about +17% upside versus a price of $0.6950 (undervalued). Cautious scenario $0.5355, optimistic scenario $1.02. The calculation is refreshed regularly with new filings.
What is the intrinsic value of Aprea Therapeutics Inc (APRE)?
Intrinsic value and fair value mean the same thing: what the business is worth on its numbers, independent of the share price. For Aprea Therapeutics Inc it is $0.8160 per share (as of Sep 27, 2026), against a price of $0.6950. It is the blended result of 1 valuation models (cash flow, earnings, asset, dividend).
Is Aprea Therapeutics Inc stock overvalued or undervalued in 2026?
As of Sep 27, 2026, APRE trades below its calculated fair value: price $0.6950, fair value $0.8160, a gap of about +17% (undervalued). The calculation is refreshed with each new quarterly report, so the verdict can change during the year.
Is fair value the same as the market price of APRE?
No. The price is what the market pays today ($0.6950); the fair value is what the company's own numbers justify ($0.8160). For Aprea Therapeutics Inc the two are $0.1210 per share apart. That gap is exactly why we show both numbers side by side.
How much is Aprea Therapeutics Inc worth?
The market values Aprea Therapeutics Inc at about $9.7M (market capitalisation, as of Sep 27, 2026). Per share that is $0.6950; our models calculate a fair value of $0.8160 per share.
What do the bullish and bearish scenarios say about APRE?
Our models span a range for Aprea Therapeutics Inc: cautious scenario $0.5355, base $0.8160, optimistic $1.02 per share (as of Sep 27, 2026, price $0.6950). The range comes from different growth and margin assumptions, not from analyst opinions.
How solid is the balance sheet of Aprea Therapeutics Inc (APRE)?
Balance-sheet figures for Aprea Therapeutics Inc (as of Sep 27, 2026): return on equity −46.2%. They feed the Quality Score of 32/100, which measures business quality independently of the share price.
How far is APRE from its 52-week high?
Aprea Therapeutics Inc trades at $0.6950, about 58% below its 52-week high of $1.65 and 18% above the low of $0.5900 (as of Oct 2, 2026). Distance from the high says nothing about value: that is what the fair value of $0.8160 is for.
Which stocks are comparable to Aprea Therapeutics Inc?
From the same area (Healthcare) we also value Vertex Pharmaceuticals Incorporated, Regeneron Pharmaceuticals, Inc, argenx SE, CSL Limited, among others. Each of them has its own fair-value calculation on this site using the same models, so the comparison is like for like.
Is Aprea Therapeutics Inc stock attractive at the current price?
The data as of Sep 27, 2026: price $0.6950, calculated fair value $0.8160 (+17%), Quality Score 32/100, from 1 models. Whether that fits your horizon and risk tolerance is your call. We provide the calculation, not investment advice.
How is the fair value of APRE calculated?
We run Aprea Therapeutics Inc through 1 models from four families: discounted cash flow, earnings models, asset and balance-sheet models, and dividend models. Every model gets the same audited fundamentals; the result is the weighted average of $0.8160, with the spread shown as a cautious and an optimistic scenario.
Is it still worth investing in stocks now?
The global stock market currently sits 14.5 % above its aggregate fair value. Aprea Therapeutics Inc currently trades 15 % below its own fair value, and the market average says nothing about that. An expensive market is no reason to stay out and no reason to buy everything at once: keep a broad savings plan running, buy single stocks only with money you can do without, and hold part of your money liquid while the market is high. The full picture including sectors is on is it worth investing now.
What is the share price of Aprea Therapeutics Inc (APRE)?
The closing price on Oct 2, 2026 was $0.6950. Our model-based fair value is $0.8160, about +17% upside (undervalued). We carry closing prices from our data provider, not a live tick.
What should I pay attention to with Aprea Therapeutics Inc right now?
A fairly wide model range ($0.5355 to $1.02) leaves room in how you read the outcome. Evidence is limited here (fewer models, shorter history), so the fair value is a rougher estimate than usual.

Key figures of Aprea Therapeutics Inc

How large is the market capitalisation of Aprea Therapeutics Inc (APRE)?
The market capitalisation of Aprea Therapeutics Inc is $9.7M. The stock-market value of the whole company: share price times number of shares. It is what the market asks for the entire business today.
What are the earnings per share of Aprea Therapeutics Inc (APRE)?
Earnings per share at Aprea Therapeutics Inc are $−0.9400. Earnings per share over the last twelve months: total profit spread across every single share.
What is the return on equity of Aprea Therapeutics Inc (APRE)?
The return on equity (ROE) of Aprea Therapeutics Inc is −46.2% (last twelve months). Profit relative to shareholders' equity, how efficiently the company works with its owners' money.
What is the EBIT return on assets of Aprea Therapeutics Inc (APRE)?
On an EBIT basis the return on assets of Aprea Therapeutics Inc is −131% (avg 5y). Operating profit (EBIT) relative to everything the company owns, as a multi-year average. It describes the business model rather than one good or bad year.
What is the operating margin of Aprea Therapeutics Inc (APRE)?
The operating margin of Aprea Therapeutics Inc is −255,026% (last twelve months). Profit from the core business (before interest and taxes) relative to revenue.
How fast is revenue growing at Aprea Therapeutics Inc (APRE)?
Revenue at Aprea Therapeutics Inc is growing −98.4% versus a year earlier. How much revenue grew versus a year earlier (YoY). The 3-year average next to it puts the single year in context.
How much free cash flow does Aprea Therapeutics Inc (APRE) generate?
The free cash flow of Aprea Therapeutics Inc is −$12.9M (fiscal year 2025). The cash truly left after running and investing in the business, this is what pays dividends and buybacks.
How much net cash does Aprea Therapeutics Inc (APRE) hold?
Aprea Therapeutics Inc holds more cash than debt, $14.6M net (fiscal year 2025). The company holds more cash than debt, a safety cushion.
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