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Cue Biopharma (CUE) Fair Value & Analysis

Healthcare · US · Market cap $120M · ISIN US22978P1066

What is Cue Biopharma really worth?

CB Cue Biopharma logo Cue Biopharma CUE · US
Price$27.44
Fair Value$5.05
Upside−81.6%
Quality44/100

Below-average quality, and trading another 443% above our fair value of $5.05.

As of Aug 23, 2026, the fair value of Cue Biopharma is $5.05 per share against a price of $27.44, so the fair value sits 82% below the price. A model estimate blended from multiple valuation models, recalculated regularly.

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Risks

!Mixed Growth (revenue 5y +54.2 %/yr)
!Loss-making · -59.7% net margin
!negative free cash flow
!Trails peers (3/9)
!Narrow moat 6/100
!Evidence only low, so the estimate is less certain
Evidence: Low Range $3.33 – $6.31

Fair value as of: Aug 23, 2026

From 1 valuation models · updated 14 days ago

Share price +3.0% over the past month.

What runs behind every stock

69 individual criteria per stock, every one traceable See the method →

What matters now

  • The price sits above even our optimistic bull case ($6.31). The favourable scenario is already priced in.
  • Weak quality (44/100) and above fair value at the same time, the margin of safety is missing on both counts.
  • The large gap to fair value rests on thin data (low evidence): fewer applicable models and a shorter history. Read it with extra caution.
  • A fairly wide model range ($3.33 to $6.31) leaves room in how you read the outcome.

Price vs Fair Value (5 years)

$535.50 $5.31 Fair Value $5.05 Jun 2021 Sep 2026

White line = price, green steps = our fair value per fiscal year, dashed = 300-day average. As of Aug 23, 2026.

How to read this chart

60‑month range $5.31 – $535.50 · fair‑value band $3.33 – $6.31 · the $27.44 price screens above the $5.05 fair value. Green steps = our fair value per fiscal year (point-in-time, no hindsight). Dashed = 300-day average. As of Aug 23, 2026.

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Analysis

Cue Biopharma (CUE) currently trades at $27.44, while our model-based Fair Value estimate is $5.05, implying the stock looks roughly 443.5% overvalued today. The Quality Score stands at 44/100 (below-average quality), in the Healthcare sector. How firm this estimate is: it rests on 1 models at a data quality of 95/100, which puts the evidence level at low.

Over the trailing twelve months, Cue Biopharma generated revenue of $32.7M at a net margin of −59.7%. The balance sheet holds a net cash position of $22.9M. Fundamentals as of Aug 23, 2026

Our scenario range runs from $3.33 (bear case) to $6.31 (bull case); at $27.44, the current price sits above that range. Bear and bull are the same models run on conservative and optimistic assumptions (margins, growth, valuation multiples), so a plausible valuation range, not a price target. The share trades about 34% below its 52-week high, currently above its 200-day average. For context, the median of 10 Healthcare peers we cover trades at −56% fair-value upside, at −82%, CUE screens richer than that median.

Fair Value models

Each model estimates fair value its own way; the Fair Value above is the evidence-weighted, family-balanced blend. Evidence (0–100) measures how completely this model’s inputs are available: well-fed models carry more weight in the blend. The spread across models is intentional, each one stresses a different value driver; dividend models, for instance, come out structurally low when payout is small. Every input is real reported data, nothing guessed.

Model Bear Bear = the cautious scenario: the same model computed with conservative anchors (lower growth, margins and valuation multiples). Together with Bull it frames a plausible valuation range, not a price target.BaseBull Bull = the optimistic scenario: the same model computed with favourable anchors (higher growth, margins and valuation multiples). Together with Bear it frames a plausible valuation range, not a price target. Evidence
Highest evidence
NCAV (Graham) best evidence $3.15 $4.22 $6.29 51
All 1 models by family
Asset-Based
NCAV (Graham) best evidence $3.15 $4.22 $6.29 51

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Key figures & financial health

P/S ratio 3.65 TTM
EPS (TTM) $−4.53
Net margin −96.9% FY2025
Return on equity −139% TTM
Return on assets (EBIT) −77.4% avg 5y
Operating margin −94.3% TTM
More key figures
Growth
Revenue (TTM) $32.7M TTM
Revenue growth (YoY) +12.5% 3y avg +180%
Balance sheet & cash flow
Free cash flow −$21.9M FY2025
Net cash $22.9M FY2025

Figures from reported company fundamentals · as of Aug 23, 2026. TTM = trailing twelve months.

Quality Score breakdown

Overall quality 44/100

Of which business quality 45 · Market factors (momentum, volatility) 43

Profitability 29
Margins and returns on capital today
Quality Growth 90
Are margins and returns improving?
Cashflow 7
Earnings quality: real cash, not paper profit
Fin. Strength 72
Balance sheet, leverage, solvency risk
Investment 100
Disciplined investing over empire-building
Low Volatility 0
Calm price path (market factor)
Momentum 64
Price trend over the last 3–12 months (market factor)
52W Momentum 57
Distance to the 52-week high (market factor)
Net Issuance 0
Buybacks instead of dilution

Non-valuation factor families (profitability, growth, cashflow, financial strength, momentum …), each academically grounded. Valuation itself sits in the Fair Value and is deliberately excluded here to avoid double-counting.

All values are scores from 0 to 100 (100 = best against fixed, research-based bands), not percentages. The three market factors (momentum, 52-week proximity, low volatility) are displayed but carry zero weight in the headline number: market sentiment is not a business property.

About the company

Cue Biopharma, Inc., a clinical-stage biopharmaceutical company, develops a novel class of injectable therapeutics to selectively engage and modulate targeted, disease relevant T cells in the United States.

Full company description

Cue Biopharma, Inc., a clinical-stage biopharmaceutical company, develops a novel class of injectable therapeutics to selectively engage and modulate targeted, disease relevant T cells in the United States. Its lead drug product candidate is the CUE-401, a bifunctional fusion protein designed to promote immune tolerance by inducing iTregs from Teff cells which is in preclinical trial; and CUE-501, a treatment of autoimmune disease via anti-viral T cell-mediated depletion of B cells. The company also develops CUE-101, which is in phase 1b clinical trial to treat HPV+ recurrent metastatic, or head and neck squamous cell carcinoma in second line, and beyond patients as a monotherapy, as well as in phase 1b clinical trial for the treatment of head and neck squamous cell carcinoma as a first line, therapy in combination with standard of care KEYTRUDA; and CUE-102, which is in phase 1b clinical trial as a monotherapy in late line recurrent metastatic WT1+ colorectal, gastric, ovarian, and pancreatic cancer. It has collaboration agreements with LG Chem, Ltd. for the development of CUE-101 and CUE-102 Immuno-STATs; collaboration and option agreement with Ono Pharmaceutical Co., Ltd to development and commercialization rights for CUE-401; and license agreement with Albert Einstein College of Medicine. The company was formerly known as Imagen Biopharma, Inc. and changed its name to Cue Biopharma, Inc. in October 2016. Cue Biopharma, Inc. was incorporated in 2014 and is headquartered in Boston, Massachusetts.

Company description, as reported by the company or data provider.

Revenue & earnings trend

FY2021 – FY2025 · reported fiscal years

Cue Biopharma reported revenue of $27.5M in FY2025 versus $14.9M in FY2021, a compound +16.4%/yr. Reported net income was −$26.6M in FY2025.

Growth Quality 33/100
Revenue is growing, but margins or cash flow do not fully confirm the trend.
Latest Revenue (FY 2025)
$27.5M
Latest YoY
+195.7%
Avg. revenue growth/yr (5Y) Measures the company's TOTAL revenue from reported annual statements: compound average growth per year (CAGR) from the fiscal year 3, 5 or N years back to the most recent comparable fiscal year. Not per share: buybacks do not change this number, and a merger can appear as a growth jump.
+54.2%
Avg. revenue growth/yr (7Y) Measures the company's TOTAL revenue from reported annual statements: compound average growth per year (CAGR) from the fiscal year 3, 5 or N years back to the most recent comparable fiscal year. Not per share: buybacks do not change this number, and a merger can appear as a growth jump.
+57.5%
EBIT margin (trend) Operating margin then vs now, from reported annual statements. A falling margin after a boom year is the classic peak-earnings signal: the growth rate then leans on an inflated base.
−1,428.0% (2020) → −96.6% (2025)
Value creation/yr We only publish this rate when it is defensible. Reason: fiscal 2025 is a loss year, no rate is defined from a loss
not computed
Revenue +16.4%/yr
FY21 $14.9M
FY22 $1.2M
FY23 $5.5M
FY24 $9.3M
FY25 $27.5M
Net income
FY21 −$44.2M
FY22 −$53.0M
FY23 −$50.7M
FY24 −$40.7M
FY25 −$26.6M

CUE screens 443% overvalued. Compare with Vertex Pharmaceuticals Incorporated →

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Cite: Fair Value Calculator (2026). "Cue Biopharma Fair Value". https://www.fairvalue-calculator.com/stock/CUE.US

Peer Group

Biotechnology · 627 stocks

How this stock ranks against its industry: the green marker is this stock, the band is the typical 25–75% peer range, and the tick is the median.

Quality Score 45 · Above median
Fair Value upside −82% · Bottom 25%
Return on assets −46% · Bottom 25%
Net margin (TTM) −60% · Bottom 25%
Operating margin (TTM) −94% · Bottom 25%
Revenue growth 13% · Above median

Valuation Multiples vs Biotechnology median · lower = cheaper

P/B 4.52× · Pricier than 75% of peers
P/S (TTM) 3.65× · Cheaper than median

Strength profile in five axes (Snowflake)

Five quick dimensions, each 0 to 100: VALUE (fair-value potential), FUTURE (revenue growth), PAST (return on equity), HEALTH (low debt), DIVIDEND (yield). Green = this stock, grey = typical sector peer.

VALUEFUTUREPASTHEALTHDIVIDEND
This stock
VALUEFUTUREPASTHEALTHDIVIDEND
Sector peers
VALUE0 · sector 0
FUTURE63 · sector 0
PAST0 · sector 0
HEALTH0 · sector 98
DIVIDEND0 · sector 26

VALUE 0: the price sits above our fair-value range.

Values & ESG

Does this company touch areas you may want to avoid? The classification is inferred from sector and industry.

None of the checked exposures detected

Similar stocks

10 more Biotechnology stocks, each showing price versus our Fair Value estimate (as of Aug 23, 2026).

Stock Price Fair Value vs Fair Value
Vertex Pharmaceuticals Incorporated VRTX $547.55 $278.78 −49%
Regeneron Pharmaceuticals, Inc REGN $807.71 $594.40 −26%
argenx SE ARGX €877.60 €292.84 −67%
BeOne Medicines AG 688235 ¥271.00 ¥47.36 −83%
Samsung Biologics Co 207940 1,518,000 KRW 1,055,793 KRW −30%
Alnylam Pharmaceuticals, Inc ALNY $228.61 $51.70 −77%
Royalty Pharma plc RPRX $60.58 $24.22 −60%
Celltrion, Inc 068270 190,700 KRW 74,519 KRW −61%
BioNTech SE BNTX $103.76 $45.70 −56%
Incyte Corporation INCY $123.22 $115.79 −6%

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Frequently asked questions

Is Cue Biopharma (CUE) overvalued or undervalued?
As of Aug 23, 2026, our model estimates a fair value of $5.05 versus a price of $27.44, about −82% upside (overvalued).
What is the fair value of CUE?
Our model-based fair value for Cue Biopharma is $5.05 (as of Aug 23, 2026), built from audited fundamentals. The current price: $27.44.
What is the quality score of CUE?
Cue Biopharma has a Quality Score of 44/100. It measures business quality (profitability, growth, cash flow, balance-sheet strength, investment discipline, share issuance). Market factors such as price momentum and volatility do not enter the number; they are shown separately in the detail view.
What is the price target for Cue Biopharma (CUE)?
Our model-based price target is the fair value of $5.05 (as of Aug 23, 2026) from 1 valuation models. Cautious scenario $3.33, optimistic scenario $6.31. It is a calculation from audited fundamentals, not an analyst target.
What is the Cue Biopharma stock forecast for 2026?
Our models put fair value at $5.05, about −82% upside versus a price of $27.44 (overvalued). Cautious scenario $3.33, optimistic scenario $6.31. The calculation is refreshed regularly with new filings.
What is the revenue of Cue Biopharma (CUE)?
Cue Biopharma reported trailing-twelve-month revenue of about $32.7M (latest available figure, as of Aug 23, 2026).
What is the net profit margin of CUE?
The net profit margin of Cue Biopharma is about −59.7%, meaning it is currently running at a net loss. Based on the latest reported figures.
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