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OnKure Therapeutics, Inc. (OKUR) fair value: what the stock is really worth

As of Sep 24, 2026: fair value of OnKure Therapeutics, Inc. $1.16, price $2.93, upside -60.6%, quality 20 out of 100. Calculated from audited financials with 26 valuation models and 37 quality factors, updated daily.

  1. Fair value above price? No
  2. Good quality? No
  3. Add to watchlist

Healthcare · US · ISIN US68277Q1058

OT OnKure Therapeutics, Inc. logo Thin data Sep 24, 2026

OnKure Therapeutics, Inc.

OKUR · US

Weakest SetupStrongly overvalued and low quality.

!Fair value $1.16 · Strongly overvalued (−61%)
!Quality 20/100
!negative free cash flow
!Trails peers (2/7)
!Narrow moat 5/100
!Evidence only low, so the estimate is less certain
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What runs behind every stock

26 valuation models 8 families, DCF to NCAV 37 quality factors margins, balance sheet, cashflow, debt 6 AI factors moat, what no ratio measures 2,000+ data points verified, per stock, median

69 individual criteria per stock, every one traceable See the method →

Price vs Fair Value

$110.70 $1.83 Fair Value $1.16 Jun 2021 Sep 2026

White line = price, green steps = our fair value per fiscal year, dashed = 300-day average. As of Sep 24, 2026.

How to read this chart

60‑month range $1.83 – $110.70 · fair‑value band $0.7650 – $1.45 · the $2.93 price screens above the $1.16 fair value. Dashed = 300-day average. As of Sep 24, 2026.

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Company profile

OnKure Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on the discovery and development of precision medicines that target biologically validated drivers of cancers and other diseases.

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OnKure Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on the discovery and development of precision medicines that target biologically validated drivers of cancers and other diseases. Its lead product candidate includes OKI-219, a selective inhibitor of phosphoinositide 3-kinase alpha (PI3Ka) harboring the H1047R mutation that is in Phase 1 clinical trial for the treatment of solid tumors, including breast cancer. The company was founded in 2011 and is headquartered in Boulder, Colorado.

Stock analysis

OnKure Therapeutics, Inc. (OKUR) currently trades at $2.93, while our model-based Fair Value estimate is $1.16, implying the stock looks roughly 153.5% overvalued today.

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Valuation

How firm this estimate is: it rests on 1 models at a data quality of 92/100, which puts the evidence level at low.

Scenario range: $0.7650 (bear) to $1.45 (bull), the price of $2.93 sits above it. Bear and bull are the same models on cautious and optimistic assumptions, a range, not a price target.

Quality & growth

The Quality Score stands at 20/100 (below-average quality), in the Healthcare sector.

OnKure Therapeutics, Inc. reported revenue of $0 in FY2025 versus $0 in FY2022. Reported net income was −$59.5M in FY2025.

Key figures

Market cap $146M · EPS (TTM) $−3.00 · Return on equity −46.9% · Return on assets (EBIT) −92.8% · Free cash flow −$51.9M · Net cash $58.5M.

Competitive moat

Our AI-assisted moat analysis scores the competitive advantage at 27 out of 100 (low confidence).

What moves the price

The share trades about 44% below its 52-week high and 26% above its 52-week low, currently below its 200-day average.

For context, the median of 10 Healthcare peers we cover trades at −5% fair-value upside, at −61%, OKUR screens richer than that median.

Fair Value models

Bear $0.7650 Fair Value $1.16 Bull $1.45
Model ⓘEach model values the company its own way (discounted cash flow, earnings, assets, dividends). The fair value above is their evidence-weighted blend, not the output of a single model. Bear ⓘBear = the cautious scenario: the same model computed with conservative anchors (lower growth, margins and valuation multiples). Together with Bull it frames a plausible valuation range, not a price target.BaseBull ⓘBull = the optimistic scenario: the same model computed with favourable anchors (higher growth, margins and valuation multiples). Together with Bear it frames a plausible valuation range, not a price target. Evidence ⓘEvidence = how well-backed THIS model's estimate is for this stock (0–100): how complete and reliable its input data are, and how well the model fits the company. The final Fair Value is an evidence-weighted blend, so better-evidenced models count more. Green ≥70, amber 50–69, grey below 50.
Highest evidence
NCAV (Graham) $0.7000 $0.9300 $1.39 51
All 1 models by family
Asset-Based
NCAV (Graham) $0.7000 $0.9300 $1.39 51

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Quality Score breakdown

Overall quality 20/100

Of which business quality 29 · Market factors (momentum, volatility) 23

Profitability 0
Margins and returns on capital today
Quality Growth 25
Are margins and returns improving?
Cashflow 25
Earnings quality: real cash, not paper profit
Fin. Strength 100
Balance sheet, leverage, solvency risk
Investment 0
Disciplined investing over empire-building
Low Volatility 0
Calm price path (market factor)
Momentum 31
Price trend over the last 3–12 months (market factor)
52W Momentum 36
Distance to the 52-week high (market factor)
Net Issuance 0
Share count: buybacks or dilution?

Open the full quality analysis →

Revenue & earnings trend

What shareholders gained per year ⓘWe only publish this rate when it is defensible. Reason: fiscal 2025 is a loss year, no rate is defined from a loss
not computed

OKUR screens 153% overvalued. Compare with Vertex Pharmaceuticals Incorporated →

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Peer GroupⓘHow this stock ranks against its industry: the green marker is this stock, the band is the typical 25–75% peer range, and the tick is the median.Biotechnology · 654 stocks

Beats the industry median on 2/6 measures
Overall it trails its industry peers.
Valuation
Quality Score 29 · Bottom 25%
Fair Value upside −61% · Below median
Profitability
Return on assets −29% · Bottom 25%
Operating margin (TTM) 0% · Above median
Growth and dividend
Revenue growth 0% · Above median

Valuation Multiplesvs Biotechnology median · lower = cheaper

P/B 2.60× · Pricier than median

Context: sector, industry, market

Values & ESG

Does this company touch areas you may want to avoid? The classification is inferred from sector and industry.

None of the checked exposures detected

Similar stocks

10 more Biotechnology stocks, each showing price versus our Fair Value estimate.

Stock Price Fair Value vs Fair Value
Vertex Pharmaceuticals Incorporated VRTX $522.38 $574.62 +10%
Regeneron Pharmaceuticals, Inc REGN $801.82 $1,252 +56%
argenx SE ARGX $963.79 $918.60 −5%
Samsung Biologics Co 207940 1,366,000 KRW 1,502,600 KRW +10%
CSL Limited CSL A$179.12 A$197.03 +10%
Alnylam Pharmaceuticals, Inc ALNY $251.65 $218.36 −13%
Royalty Pharma plc RPRX $58.52 $24.22 −59%
BeOne Medicines AG 6160 HK$218.20 HK$169.72 −22%
Celltrion, Inc 068270 177,400 KRW 74,519 KRW −58%
BioNTech SE BNTX $100.87 $63.62 −37%

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OnKure Therapeutics, Inc. · Fair Value
$1.16 −153%Fair Value
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Cite: Fair Value Calculator (2026). "OnKure Therapeutics, Inc. Fair Value". https://www.fairvalue-calculator.com/stock/OKUR

Frequently asked questions

Is OnKure Therapeutics, Inc. (OKUR) overvalued or undervalued?
As of Sep 24, 2026, our model estimates a fair value of $1.16 versus a price of $2.93, about −61% upside (overvalued).
What is the fair value of OKUR?
Our model-based fair value for OnKure Therapeutics, Inc. is $1.16 (as of Sep 24, 2026), built from audited fundamentals. The current price: $2.93.
What is the quality score of OKUR?
OnKure Therapeutics, Inc. has a Quality Score of 20/100. It measures business quality (profitability, growth, cash flow, balance-sheet strength, investment discipline, share issuance). Market factors such as price momentum and volatility do not enter the number; they are shown separately in the detail view.
What is the price target for OnKure Therapeutics, Inc. (OKUR)?
Our model-based price target is the fair value of $1.16 (as of Sep 24, 2026) from 1 valuation models. Cautious scenario $0.7650, optimistic scenario $1.45. It is a calculation from audited fundamentals, not an analyst target.
What is the OnKure Therapeutics, Inc. stock forecast for 2026?
Our models put fair value at $1.16, about −61% upside versus a price of $2.93 (overvalued). Cautious scenario $0.7650, optimistic scenario $1.45. The calculation is refreshed regularly with new filings.
What is the intrinsic value of OnKure Therapeutics, Inc. (OKUR)?
Intrinsic value and fair value mean the same thing: what the business is worth on its numbers, independent of the share price. For OnKure Therapeutics, Inc. it is $1.16 per share (as of Sep 24, 2026), against a price of $2.93. It is the blended result of 1 valuation models (cash flow, earnings, asset, dividend).
Is OnKure Therapeutics, Inc. stock overvalued or undervalued in 2026?
As of Sep 24, 2026, OKUR trades above its calculated fair value: price $2.93, fair value $1.16, a gap of about −61% (overvalued). The calculation is refreshed with each new quarterly report, so the verdict can change during the year.
Is fair value the same as the market price of OKUR?
No. The price is what the market pays today ($2.93); the fair value is what the company's own numbers justify ($1.16). For OnKure Therapeutics, Inc. the two are $1.77 per share apart. That gap is exactly why we show both numbers side by side.
How much is OnKure Therapeutics, Inc. worth?
The market values OnKure Therapeutics, Inc. at about $146M (market capitalisation, as of Sep 24, 2026). Per share that is $2.93; our models calculate a fair value of $1.16 per share.
What do the bullish and bearish scenarios say about OKUR?
Our models span a range for OnKure Therapeutics, Inc.: cautious scenario $0.7650, base $1.16, optimistic $1.45 per share (as of Sep 24, 2026, price $2.93). The range comes from different growth and margin assumptions, not from analyst opinions.
How solid is the balance sheet of OnKure Therapeutics, Inc. (OKUR)?
Balance-sheet figures for OnKure Therapeutics, Inc. (as of Sep 24, 2026): return on equity −46.9%. They feed the Quality Score of 20/100, which measures business quality independently of the share price.
How far is OKUR from its 52-week high?
OnKure Therapeutics, Inc. trades at $2.93, about 44% below its 52-week high of $5.27 and 26% above the low of $2.32 (as of Sep 24, 2026). Distance from the high says nothing about value: that is what the fair value of $1.16 is for.
Which stocks are comparable to OnKure Therapeutics, Inc.?
From the same area (Healthcare) we also value Vertex Pharmaceuticals Incorporated, Regeneron Pharmaceuticals, Inc, argenx SE, Samsung Biologics Co, among others. Each of them has its own fair-value calculation on this site using the same models, so the comparison is like for like.
Is OnKure Therapeutics, Inc. stock attractive at the current price?
The data as of Sep 24, 2026: price $2.93, calculated fair value $1.16 (−61%), Quality Score 20/100, from 1 models. Whether that fits your horizon and risk tolerance is your call. We provide the calculation, not investment advice.
How is the fair value of OKUR calculated?
We run OnKure Therapeutics, Inc. through 1 models from four families: discounted cash flow, earnings models, asset and balance-sheet models, and dividend models. Every model gets the same audited fundamentals; the result is the weighted average of $1.16, with the spread shown as a cautious and an optimistic scenario.
Is it still worth investing in stocks now?
The global stock market currently sits 14.0 % above its aggregate fair value. OnKure Therapeutics, Inc. itself currently trades above fair value. An expensive market is no reason to stay out and no reason to buy everything at once: keep a broad savings plan running, buy single stocks only with money you can do without, and hold part of your money liquid while the market is high. The full picture including sectors is on is it worth investing now.
What is the share price of OnKure Therapeutics, Inc. (OKUR)?
The closing price on Sep 24, 2026 was $2.93. Our model-based fair value is $1.16, about −61% upside (overvalued). We carry closing prices from our data provider, not a live tick.
What should I pay attention to with OnKure Therapeutics, Inc. right now?
The price sits above even our optimistic bull case ($1.45). The favourable scenario is already priced in. Weak quality (20/100) and above fair value at the same time, the margin of safety is missing on both counts. The large gap to fair value rests on thin data (low evidence): fewer applicable models and a shorter history. Read it with extra caution. A fairly wide model range ($0.7650 to $1.45) leaves room in how you read the outcome.

Key figures of OnKure Therapeutics, Inc.

How large is the market capitalisation of OnKure Therapeutics, Inc. (OKUR)?
The market capitalisation of OnKure Therapeutics, Inc. is $146M. The stock-market value of the whole company: share price times number of shares. It is what the market asks for the entire business today.
What are the earnings per share of OnKure Therapeutics, Inc. (OKUR)?
Earnings per share at OnKure Therapeutics, Inc. are $−3.00. Earnings per share over the last twelve months: total profit spread across every single share.
What is the return on equity of OnKure Therapeutics, Inc. (OKUR)?
The return on equity (ROE) of OnKure Therapeutics, Inc. is −46.9% (last twelve months). Profit relative to shareholders' equity, how efficiently the company works with its owners' money.
What is the EBIT return on assets of OnKure Therapeutics, Inc. (OKUR)?
On an EBIT basis the return on assets of OnKure Therapeutics, Inc. is −92.8% (avg 5y). Operating profit (EBIT) relative to everything the company owns, as a multi-year average. It describes the business model rather than one good or bad year.
How much free cash flow does OnKure Therapeutics, Inc. (OKUR) generate?
The free cash flow of OnKure Therapeutics, Inc. is −$51.9M (fiscal year 2025). The cash truly left after running and investing in the business, this is what pays dividends and buybacks.
How much net cash does OnKure Therapeutics, Inc. (OKUR) hold?
OnKure Therapeutics, Inc. holds more cash than debt, $58.5M net (fiscal year 2025). The company holds more cash than debt, a safety cushion.
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