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OnKure Therapeutics, Inc. (OKUR) fair value: what the stock is really worth

As of Nov 9, 2026: fair value (intrinsic value) of OnKure Therapeutics, Inc. stock $1.16, price $3.19, that is 63.8% below the price, quality 29 out of 100. Rating: strongly overvalued. Calculated from audited financials with one of our 26 valuation models and 37 quality factors, updated daily.

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Healthcare US

OT OnKure Therapeutics, Inc. logo Thin data Nov 10, 2026

OnKure Therapeutics, Inc.

OKUR · US
Very expensive, weak quality

Our calculation puts a fair price 64% below what the stock costs today.

Insiders sold $2,867 (6M)
Fair value $1.16 · Strongly overvalued
Quality 29/100
Negative free cash flow
Trails peers (2/7)
Narrow moat 5/100 · thin data
Thin data
⚠ Dilution
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What runs behind every stock

26 valuation models 8 families, DCF to NCAV 37 quality factors margins, balance sheet, cashflow, debt 6 AI factors moat, what no ratio measures 2,000+ data points verified, per stock, median

69 individual criteria per stock, every one traceable See the method →

Price vs Fair Value

$110.70 $1.83 Fair Value $1.16 Aug 2021 Nov 2026

White line = price, green steps = our fair value per fiscal year. As of Nov 10, 2026.

How to read this chart

60‑month range $1.83 – $110.70 · fair‑value band $0.7565 – $1.44 · the $3.19 price screens above the $1.16 fair value. As of Nov 10, 2026.

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Company profile

OnKure Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on the discovery and development of precision medicines that target biologically validated drivers of cancers and other diseases.

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Its lead product candidate includes OKI-219, a selective inhibitor of phosphoinositide 3-kinase alpha (PI3Ka) harboring the H1047R mutation that is in Phase 1 clinical trial for the treatment of solid tumors, including breast cancer.

The company was founded in 2011 and is headquartered in Boulder, Colorado.

Stock analysis

OnKure Therapeutics, Inc. (OKUR) currently trades at $3.19, while our model-based Fair Value estimate is $1.16, 64% below the price, so the stock looks overvalued today.

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Valuation

How firm this estimate is: it rests on 1 models at a data quality of 92/100, which puts the data coverage at low.

Scenario range: $0.7565 (bear) to $1.44 (bull), the price of $3.19 sits above it. Bear and bull are the same models on cautious and optimistic assumptions, a range, not a price target.

Quality & growth

The Quality Score stands at 29/100 (below-average quality), in the Healthcare sector.

OnKure Therapeutics, Inc. reported revenue of $0 in FY2025 versus $0 in FY2022. Reported net income was −$59.5M in FY2025.

Key figures

Market cap $159M Micro · EPS (TTM) $−2.26 · Return on equity −55.2% · Return on assets (EBIT) −92.8% (5-year average) · Free cash flow −$51.9M · Net cash $58.5M.

Competitive moat

Our AI-assisted moat analysis scores the competitive advantage at 5 out of 100 (low confidence).

What moves the price

The share trades about 39% below its 52-week high and 52% above its 52-week low, currently below its 200-day average.

For context, the median of 10 Healthcare peers we cover trades at 6% fair-value upside, at −64%, OKUR screens richer than that median.

Fair Value models

Bear $0.7565 Fair Value $1.16 Bull $1.44
Price $3.19 · Downside -63.8%
Model ⓘEach model values the company its own way (discounted cash flow, earnings, assets, dividends). The fair value above starts from their evidence-weighted blend, not from a single model. In cyclical trough or peak years, after dilution or a stock split it is adjusted afterwards, so it can sit above or below the models. Bear ⓘBear = the cautious scenario: the same model computed with conservative anchors (lower growth, margins and valuation multiples). Together with Bull it frames a plausible valuation range, not a price target.BaseBull ⓘBull = the optimistic scenario: the same model computed with favourable anchors (higher growth, margins and valuation multiples). Together with Bear it frames a plausible valuation range, not a price target. If a model's bull case is above four times its base value, the table shows that limit with a > sign (like the overall Bull above): beyond it no assumption holds. Coverage ⓘCoverage = how well-backed THIS model's estimate is for this stock (0–100): how complete and reliable its input data are, and how well the model fits the company. The final Fair Value is an evidence-weighted blend, so better-evidenced models count more. Green ≥70, amber 50–69, grey below 50.
Best data coverage
NCAV (Graham) $0.8900 $1.36 $1.69 52
All 1 models by family
Asset-Based
NCAV (Graham) $0.8900 $1.36 $1.69 52

The fair value above starts from this blend and is adjusted for dilution from new shares.

Open the full fair value analysis →

Quality Score breakdown

Overall quality 29/100

It rates the business: profits, how they develop, real cash, balance sheet, investing and share count.

Profitability 0
How much profit the company makes from its sales and capital
Quality Growth 25
Are margins and returns getting better?
Cashflow 25
Do the profits arrive as real cash?
Financial strength 100
Debt, balance sheet and risk of trouble
Investment 0
Does it invest with discipline instead of growing at any price?
Low Volatility 41
How calm the share price moves, does not count
Price momentum 17
Price momentum of the last 3 to 12 months, does not count
Near the 52-week high 34
Distance to the 52-week high, does not count
New shares 0
Buys back shares or issues new ones?

Open the full quality analysis →

Insider trades

In the last 6 months, 2 officers or directors sold shares worth $2,867 and none bought.

  • SaleNicholas A SaccomanoPresident and CEO, Director4× since Dec 22, 2025: 346 shares, avg. $3.62$1,253Sep 21, 2026
  • SaleJason A. LeveroneChief Financial Officer4× since Dec 22, 2025: 1,208 shares, avg. $3.63$4,379Sep 21, 2026

Sales are often planned (taxes, diversification, 10b5-1 plans). Purchases with their own money are seen as the stronger sign. For information only: not part of the quality score or Fair Value.

Source: SEC Form 4, as of Nov 9, 2026. All filings at the SEC ↗

Revenue & earnings trend

What shareholders gained per year ⓘWe only publish this rate when it is defensible. Reason: fiscal 2025 is a loss year, no rate is defined from a loss
not computed

OKUR screens overvalued: fair value 64% below the price. Compare with Vertex Pharmaceuticals Incorporated →

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Peer GroupⓘHow this stock ranks against its industry: the green marker is this stock, the band is the typical 25–75% peer range, and the tick is the median.Biotechnology · 558 stocks

Beats the industry median on 2/6 measures
Overall it trails its industry peers.
Valuation
Quality Score 29 · Bottom 25%
Fair Value upside −63.8% · Below median
Profitability
Return on assets −95.8% · Bottom 25%
Operating margin (12 months) 0.0% · Above median
Growth and dividend
Revenue growth (quarter YoY) 0.0% · Above median

Valuation Multiplesvs Biotechnology median · lower = cheaper

P/B 2.83× · Pricier than median

Context: sector, industry, market

Values & ESG

Does this company touch areas you may want to avoid? The classification is inferred from sector and industry.

None of the checked exposures detected

Similar stocks

10 more Biotechnology stocks, each showing price versus our Fair Value estimate.

Stock Price Fair Value vs Fair Value Compare
Regeneron Pharmaceuticals, Inc REGN $919.96 $1,275 +39% vs OKUR
Samsung Biologics Co 207940 1,510,000 KRW 1,667,600 KRW +10% vs OKUR
Vertex Pharmaceuticals Incorporated VRTX $550.87 $601.80 +9% vs OKUR
WuXi Biologics (Cayman) Inc 2269 HK$48.92 HK$52.38 +7% vs OKUR
Genmab A/S GMAB kr 3,661 kr 3,880 +6% vs OKUR
argenx SE ARGX $962.27 $908.40 −6% vs OKUR
CSL Limited CSL A$200.73 A$181.40 −10% vs OKUR
BeOne Medicines AG 6160 HK$248.20 HK$152.80 −38% vs OKUR
Celltrion, Inc 068270 210,000 KRW 74,945 KRW −64% vs OKUR
Royalty Pharma plc RPRX $68.77 $19.01 −72% vs OKUR

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OnKure Therapeutics, Inc.: fair value per Fair Value Calculator

Cite: Fair Value Calculator (2026). "OnKure Therapeutics, Inc. Fair Value". https://www.fairvalue-calculator.com/stock/OKUR

Frequently asked questions

Is OnKure Therapeutics, Inc. (OKUR) overvalued or undervalued?
As of Nov 10, 2026, our model estimates a fair value of $1.16 versus a price of $3.19, about 64% lower (overvalued).
What is the fair value of OKUR?
Our model-based fair value for OnKure Therapeutics, Inc. is $1.16 (as of Nov 10, 2026), built from audited fundamentals. The current price: $3.19.
What is the quality score of OKUR?
OnKure Therapeutics, Inc. has a Quality Score of 29/100. It measures business quality (profitability, growth, cash flow, balance-sheet strength, investment discipline, share issuance). Market factors such as price momentum and volatility do not enter the number; they are shown separately in the detail view.
What is the price target for OnKure Therapeutics, Inc. (OKUR)?
Our model-based price target is the fair value of $1.16 (as of Nov 10, 2026) from 1 valuation models. Cautious scenario $0.7565, optimistic scenario $1.44. It is a calculation from audited fundamentals, not an analyst target.
What is the OnKure Therapeutics, Inc. stock forecast for 2026?
Our models put fair value at $1.16, about 64% lower versus a price of $3.19 (overvalued). Cautious scenario $0.7565, optimistic scenario $1.44. The calculation is refreshed regularly with new filings.
What is the intrinsic value of OnKure Therapeutics, Inc. (OKUR)?
Intrinsic value and fair value mean the same thing: what the business is worth on its numbers, independent of the share price. For OnKure Therapeutics, Inc. it is $1.16 per share (as of Nov 10, 2026), against a price of $3.19. It is the blended result of 1 valuation models in 1 family (Asset-Based).
Is OnKure Therapeutics, Inc. stock overvalued or undervalued in 2026?
As of Nov 10, 2026, OKUR trades above its calculated fair value: price $3.19, fair value $1.16, a gap of about −64% (overvalued). The calculation is refreshed with each new quarterly report, so the verdict can change during the year.
Is fair value the same as the market price of OKUR?
No. The price is what the market pays today ($3.19); the fair value is what the company's own numbers justify ($1.16). For OnKure Therapeutics, Inc. the two are $2.03 per share apart. That gap is exactly why we show both numbers side by side.
How much is OnKure Therapeutics, Inc. worth?
The market values OnKure Therapeutics, Inc. at about $159M (market capitalisation, as of Nov 10, 2026). Per share that is $3.19; our models calculate a fair value of $1.16 per share.
What do the bullish and bearish scenarios say about OKUR?
Our models span a range for OnKure Therapeutics, Inc.: cautious scenario $0.7565, base $1.16, optimistic $1.44 per share (as of Nov 10, 2026, price $3.19). The range comes from different growth and margin assumptions, not from analyst opinions.
How solid is the balance sheet of OnKure Therapeutics, Inc. (OKUR)?
Balance-sheet figures for OnKure Therapeutics, Inc. (as of Nov 10, 2026): return on equity −55.2%. They feed the Quality Score of 29/100, which measures business quality independently of the share price.
How far is OKUR from its 52-week high?
OnKure Therapeutics, Inc. trades at $3.19, about 39% below its 52-week high of $5.27 and 52% above the low of $2.10 (as of Nov 9, 2026). Distance from the high says nothing about value: that is what the fair value of $1.16 is for.
Which stocks are comparable to OnKure Therapeutics, Inc.?
From the same area (Healthcare) we also value Vertex Pharmaceuticals Incorporated, Regeneron Pharmaceuticals, Inc, CSL Limited, argenx SE, among others. Each of them has its own fair-value calculation on this site using the same models, so the comparison is like for like.
Is OnKure Therapeutics, Inc. stock attractive at the current price?
The data as of Nov 10, 2026: price $3.19, calculated fair value $1.16 (−64%), Quality Score 29/100, from 1 models. Whether that fits your horizon and risk tolerance is your call. We provide the calculation, not investment advice.
How is the fair value of OKUR calculated?
We run OnKure Therapeutics, Inc. through 1 models from 1 family: Asset-Based. Every model gets the same audited fundamentals; the fair value of $1.16 builds on their evidence-weighted average, with the spread shown as a cautious and an optimistic scenario.
Is it still worth investing in stocks now?
The global stock market currently sits 13.7% above its aggregate fair value. OnKure Therapeutics, Inc. itself currently trades above fair value. An expensive market is no reason to stay out and no reason to buy everything at once: keep a broad savings plan running, buy single stocks only with money you can do without, and hold part of your money liquid while the market is high. The full picture including sectors is on is it worth investing now.
What is the share price of OnKure Therapeutics, Inc. (OKUR)?
The closing price on Nov 9, 2026 was $3.19. Our model-based fair value is $1.16, about 64% lower (overvalued). We carry closing prices from our data provider, not a live tick.
What should I pay attention to with OnKure Therapeutics, Inc. right now?
The price sits above even our optimistic bull case ($1.44). The favourable scenario is already priced in. Weak quality (29/100) and above fair value at the same time, the margin of safety is missing on both counts. The large gap to fair value rests on thin data (low evidence): fewer applicable models and a shorter history. Read it with extra caution. A fairly wide model range ($0.7565 to $1.44) leaves room in how you read the outcome.

Key figures of OnKure Therapeutics, Inc.

How large is the market capitalisation of OnKure Therapeutics, Inc. (OKUR)?
The market capitalisation of OnKure Therapeutics, Inc. is $159M. The stock-market value of the whole company: share price times number of shares. It is what the market asks for the entire business today.
What are the earnings per share of OnKure Therapeutics, Inc. (OKUR)?
Earnings per share at OnKure Therapeutics, Inc. are $−2.26. Earnings per share over the last twelve months: total profit spread across every single share.
What is the return on equity of OnKure Therapeutics, Inc. (OKUR)?
The return on equity (ROE) of OnKure Therapeutics, Inc. is −55.2% (last twelve months). Profit relative to shareholders' equity, how efficiently the company works with its owners' money.
What is the EBIT return on assets of OnKure Therapeutics, Inc. (OKUR)?
On an EBIT basis the return on assets of OnKure Therapeutics, Inc. is −92.8% (avg 5y). Operating profit (EBIT) relative to everything the company owns, as a multi-year average. It describes the business model rather than one good or bad year.
How much free cash flow does OnKure Therapeutics, Inc. (OKUR) generate?
The free cash flow of OnKure Therapeutics, Inc. is −$51.9M (fiscal year 2025). The cash truly left after running and investing in the business, this is what pays dividends and buybacks.
How much net cash does OnKure Therapeutics, Inc. (OKUR) hold?
OnKure Therapeutics, Inc. holds more cash than debt, $58.5M net (fiscal year 2025). The company holds more cash than debt, a safety cushion.
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