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ProQR Therapeutics BV (PRQR) fair value: what the stock is really worth

As of Sep 22, 2026: fair value of ProQR Therapeutics BV $0.34, price $1.90, upside -82.1%, quality 27 out of 100. Calculated from audited financials with 26 valuation models and 37 quality factors, updated daily.

  1. Fair value above price? No
  2. Good quality? No
  3. Add to watchlist

Healthcare · US · ISIN NL0010872495

PT ProQR Therapeutics BV logo Thin data Sep 24, 2026

ProQR Therapeutics BV

PRQR · US

Weakest SetupStrongly overvalued and low quality.

!Fair value $0.3400 · Strongly overvalued (−82%)
!Quality 27/100
!Mixed Growth (revenue 5y +71.5 %/yr)
!Low debt · negative free cash flow
!Trails peers (0/8)
!Narrow moat 16/100
!Evidence only low, so the estimate is less certain
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What runs behind every stock

26 valuation models 8 families, DCF to NCAV 37 quality factors margins, balance sheet, cashflow, debt 6 AI factors moat, what no ratio measures 2,000+ data points verified, per stock, median

69 individual criteria per stock, every one traceable See the method →

Price vs Fair Value

$8.47 $0.5601 Fair Value $0.3400 Jun 2021 Sep 2026

White line = price, green steps = our fair value per fiscal year, dashed = 300-day average. As of Sep 24, 2026.

How to read this chart

60‑month range $0.5601 – $8.47 · fair‑value band $0.2210 – $0.4250 · the $1.90 price screens above the $0.3400 fair value. Green steps = our fair value per fiscal year (point-in-time, no hindsight). Dashed = 300-day average. As of Sep 24, 2026.

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Company profile

ProQR Therapeutics N.V., a clinical-stage biotechnology company, focuses on the discovery and development of novel therapeutic medicines. The company develops an RNA editing platform through its Axiomer RNA editing technology for genetic disorders with unmet needs.

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ProQR Therapeutics N.V., a clinical-stage biotechnology company, focuses on the discovery and development of novel therapeutic medicines. The company develops an RNA editing platform through its Axiomer RNA editing technology for genetic disorders with unmet needs. Its lead product candidate, AX-0810, targets na-taurocholate cotransporting polypeptide (NTCP) for the treatment of cholestatic diseases. The company also develops AX-2402, which targets methyl CpG binding protein 2 mutations for Rett syndrome; AX-2911, which targets PNPLA3 for metabolic dysfunction-associated steatohepatitis; and AX-1412, which targets the B4GALT1 gene for cardiovascular diseases. It has a research and collaboration agreement with Eli Lilly and Company for the discovery, development, and commercialization of potential new medicines for genetic disorders in the liver and nervous system. The company was incorporated in 2012 and is headquartered in Leiden, the Netherlands.

Stock analysis

ProQR Therapeutics BV (PRQR) currently trades at $1.90, while our model-based Fair Value estimate is $0.3400, implying the stock looks roughly 459.0% overvalued today.

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Valuation

How firm this estimate is: it rests on 1 models at a data quality of 95/100, which puts the evidence level at low.

Scenario range: $0.2210 (bear) to $0.4250 (bull), the price of $1.90 sits above it. Bear and bull are the same models on cautious and optimistic assumptions, a range, not a price target.

Quality & growth

The Quality Score stands at 27/100 (below-average quality), in the Healthcare sector.

Mixed Growth: Revenue is growing, but margins or cash flow do not fully confirm the trend.

ProQR Therapeutics BV reported revenue of €15.3M in FY2025 versus €1.3M in FY2021, a compound +83.9%/yr. Reported net income was −€40.5M in FY2025.

Key figures

Market cap $200M · P/S ratio 14.6 · EPS (TTM) $−0.5000 · Return on equity −78.1% · Return on assets (EBIT) −28.4% · Operating margin −671% · Revenue (TTM) $13.6M · Revenue growth (YoY) −57.1%.

Competitive moat

Our AI-assisted moat analysis scores the competitive advantage at 37 out of 100 (medium confidence).

What moves the price

The share trades about 39% below its 52-week high and 43% above its 52-week low, currently below its 200-day average.

For context, the median of 10 Healthcare peers we cover trades at −5% fair-value upside, at −82%, PRQR screens richer than that median.

Fair Value models

Bear $0.2210 Fair Value $0.3400 Bull $0.4250
Model ⓘEach model values the company its own way (discounted cash flow, earnings, assets, dividends). The fair value above is their evidence-weighted blend, not the output of a single model. Bear ⓘBear = the cautious scenario: the same model computed with conservative anchors (lower growth, margins and valuation multiples). Together with Bull it frames a plausible valuation range, not a price target.BaseBull ⓘBull = the optimistic scenario: the same model computed with favourable anchors (higher growth, margins and valuation multiples). Together with Bear it frames a plausible valuation range, not a price target. Evidence ⓘEvidence = how well-backed THIS model's estimate is for this stock (0–100): how complete and reliable its input data are, and how well the model fits the company. The final Fair Value is an evidence-weighted blend, so better-evidenced models count more. Green ≥70, amber 50–69, grey below 50.
Highest evidence
NCAV (Graham) $0.2300 $0.3100 $0.4700 53
All 1 models by family
Asset-Based
NCAV (Graham) $0.2300 $0.3100 $0.4700 53

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Quality Score breakdown

Overall quality 27/100

Of which business quality 29 · Market factors (momentum, volatility) 46

Profitability 4
Margins and returns on capital today
Quality Growth 12
Are margins and returns improving?
Cashflow 17
Earnings quality: real cash, not paper profit
Fin. Strength 63
Balance sheet, leverage, solvency risk
Investment 92
Disciplined investing over empire-building
Low Volatility 50
Calm price path (market factor)
Momentum 53
Price trend over the last 3–12 months (market factor)
52W Momentum 28
Distance to the 52-week high (market factor)
Net Issuance 0
Share count: buybacks or dilution?

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Revenue & earnings trend

Growth Quality ⓘGrowth is valuable only when reinvestment earns attractive returns (Aswath Damodaran): sustainable growth depends on return on capital, reinvestment and efficiency. Basis: total company revenue over the periods shown on the cards (3Y/5Y/all years), not per share, so a merger can show up as a growth jump; per-share earnings growth is in the value-creation card. 29/100
Revenue is growing, but margins or cash flow do not fully confirm the trend.
Revenue growth 1 year
−19.2%
Revenue growth 3 years ⓘMeasures the company's TOTAL revenue from reported annual statements: compound average growth per year (CAGR) from the fiscal year 3, 5 or N years back to the most recent comparable fiscal year. Not per share: buybacks do not change this number, and a merger can appear as a growth jump. Per-share growth (which does include buybacks) is in the value-creation card.
+62.0%
Revenue growth 5 years ⓘMeasures the company's TOTAL revenue from reported annual statements: compound average growth per year (CAGR) from the fiscal year 3, 5 or N years back to the most recent comparable fiscal year. Not per share: buybacks do not change this number, and a merger can appear as a growth jump. Per-share growth (which does include buybacks) is in the value-creation card.
+71.5%
Start year 2020 (pandemic). Over 10 years: +5.0% a year
Revenue growth 13 years ⓘMeasures the company's TOTAL revenue from reported annual statements: compound average growth per year (CAGR) from the fiscal year 3, 5 or N years back to the most recent comparable fiscal year. Not per share: buybacks do not change this number, and a merger can appear as a growth jump. Per-share growth (which does include buybacks) is in the value-creation card.
+61.5%
Profit margin (trend) ⓘOperating margin then vs now, from reported annual statements. A falling margin after a boom year is the classic peak-earnings signal: the growth rate then leans on an inflated base.
−4,117.4% (2020) → −275.9% (2025)
What shareholders gained per year ⓘWe only publish this rate when it is defensible. Reason: fiscal 2025 is a loss year, no rate is defined from a loss
not computed

PRQR screens 459% overvalued. Compare with Vertex Pharmaceuticals Incorporated →

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Peer GroupⓘHow this stock ranks against its industry: the green marker is this stock, the band is the typical 25–75% peer range, and the tick is the median.Biotechnology · 648 stocks

Beats the industry median on 0/7 measures
Overall it trails its industry peers.
Valuation
Quality Score 29 · Bottom 25%
Fair Value upside −82% · Bottom 25%
Profitability
Return on assets −23% · Below median
Growth and dividend
Revenue growth −57% · Bottom 25%
Balance sheet
Debt / equity 0.09× · Above median

Valuation Multiplesvs Biotechnology median · lower = cheaper

P/B 4.06× · Priciest 25%
P/S (TTM) 14.67× · Priciest 25%

Strength profile in five axes (Snowflake)

VALUEFUTUREPASTHEALTHDIVIDEND
This stock
VALUEFUTUREPASTHEALTHDIVIDEND
Sector peers
VALUE (fair-value potential)0 · sector 0
FUTURE (revenue growth)0 · sector 0
PAST (return on equity)0 · sector 0
HEALTH (low debt)96 · sector 96
DIVIDEND (yield)0 · sector 23

VALUE 0: the price sits above our fair-value range.

Context: sector, industry, market

Values & ESG

Does this company touch areas you may want to avoid? The classification is inferred from sector and industry.

None of the checked exposures detected

Similar stocks

10 more Biotechnology stocks, each showing price versus our Fair Value estimate.

Stock Price Fair Value vs Fair Value
Vertex Pharmaceuticals Incorporated VRTX $514.99 $566.49 +10%
Regeneron Pharmaceuticals, Inc REGN $803.90 $1,252 +56%
argenx SE ARGX $963.79 $918.60 −5%
Samsung Biologics Co 207940 1,366,000 KRW 1,502,600 KRW +10%
CSL Limited CSL A$179.24 A$197.16 +10%
Alnylam Pharmaceuticals, Inc ALNY $251.65 $218.36 −13%
Royalty Pharma plc RPRX $58.52 $24.22 −59%
Celltrion, Inc 068270 177,400 KRW 74,519 KRW −58%
BeOne Medicines AG ONC $368.08 $280.94 −24%
BioNTech SE BNTX $100.87 $63.62 −37%

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ProQR Therapeutics BV · Fair Value
$0.3400 −459%Fair Value
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Cite: Fair Value Calculator (2026). "ProQR Therapeutics BV Fair Value". https://www.fairvalue-calculator.com/stock/PRQR

Frequently asked questions

Is ProQR Therapeutics BV (PRQR) overvalued or undervalued?
As of Sep 24, 2026, our model estimates a fair value of $0.3400 versus a price of $1.90, about −82% upside (overvalued).
What is the fair value of PRQR?
Our model-based fair value for ProQR Therapeutics BV is $0.3400 (as of Sep 24, 2026), built from audited fundamentals. The current price: $1.90.
What is the quality score of PRQR?
ProQR Therapeutics BV has a Quality Score of 27/100. It measures business quality (profitability, growth, cash flow, balance-sheet strength, investment discipline, share issuance). Market factors such as price momentum and volatility do not enter the number; they are shown separately in the detail view.
What is the price target for ProQR Therapeutics BV (PRQR)?
Our model-based price target is the fair value of $0.3400 (as of Sep 24, 2026) from 1 valuation models. Cautious scenario $0.2210, optimistic scenario $0.4250. It is a calculation from audited fundamentals, not an analyst target.
What is the ProQR Therapeutics BV stock forecast for 2026?
Our models put fair value at $0.3400, about −82% upside versus a price of $1.90 (overvalued). Cautious scenario $0.2210, optimistic scenario $0.4250. The calculation is refreshed regularly with new filings.
What is the revenue of ProQR Therapeutics BV (PRQR)?
ProQR Therapeutics BV reported trailing-twelve-month revenue of about $13.6M (latest available figure, as of Sep 24, 2026).
What is the intrinsic value of ProQR Therapeutics BV (PRQR)?
Intrinsic value and fair value mean the same thing: what the business is worth on its numbers, independent of the share price. For ProQR Therapeutics BV it is $0.3400 per share (as of Sep 24, 2026), against a price of $1.90. It is the blended result of 1 valuation models (cash flow, earnings, asset, dividend).
Is ProQR Therapeutics BV stock overvalued or undervalued in 2026?
As of Sep 24, 2026, PRQR trades above its calculated fair value: price $1.90, fair value $0.3400, a gap of about −82% (overvalued). The calculation is refreshed with each new quarterly report, so the verdict can change during the year.
Is fair value the same as the market price of PRQR?
No. The price is what the market pays today ($1.90); the fair value is what the company's own numbers justify ($0.3400). For ProQR Therapeutics BV the two are $1.56 per share apart. That gap is exactly why we show both numbers side by side.
How much is ProQR Therapeutics BV worth?
The market values ProQR Therapeutics BV at about $200M (market capitalisation, as of Sep 24, 2026). Per share that is $1.90; our models calculate a fair value of $0.3400 per share.
What do the bullish and bearish scenarios say about PRQR?
Our models span a range for ProQR Therapeutics BV: cautious scenario $0.2210, base $0.3400, optimistic $0.4250 per share (as of Sep 24, 2026, price $1.90). The range comes from different growth and margin assumptions, not from analyst opinions.
How solid is the balance sheet of ProQR Therapeutics BV (PRQR)?
Balance-sheet figures for ProQR Therapeutics BV (as of Sep 24, 2026): return on equity −78.1%, debt of 0.09 per unit of equity. They feed the Quality Score of 27/100, which measures business quality independently of the share price.
How far is PRQR from its 52-week high?
ProQR Therapeutics BV trades at $1.90, about 39% below its 52-week high of $3.10 and 43% above the low of $1.33 (as of Sep 24, 2026). Distance from the high says nothing about value: that is what the fair value of $0.3400 is for.
Which stocks are comparable to ProQR Therapeutics BV?
From the same area (Healthcare) we also value Vertex Pharmaceuticals Incorporated, Regeneron Pharmaceuticals, Inc, argenx SE, Samsung Biologics Co, among others. Each of them has its own fair-value calculation on this site using the same models, so the comparison is like for like.
Is ProQR Therapeutics BV stock attractive at the current price?
The data as of Sep 24, 2026: price $1.90, calculated fair value $0.3400 (−82%), Quality Score 27/100, from 1 models. Whether that fits your horizon and risk tolerance is your call. We provide the calculation, not investment advice.
How is the fair value of PRQR calculated?
We run ProQR Therapeutics BV through 1 models from four families: discounted cash flow, earnings models, asset and balance-sheet models, and dividend models. Every model gets the same audited fundamentals; the result is the weighted average of $0.3400, with the spread shown as a cautious and an optimistic scenario.
Is it still worth investing in stocks now?
The global stock market currently sits 14.1 % above its aggregate fair value. ProQR Therapeutics BV itself currently trades above fair value. An expensive market is no reason to stay out and no reason to buy everything at once: keep a broad savings plan running, buy single stocks only with money you can do without, and hold part of your money liquid while the market is high. The full picture including sectors is on is it worth investing now.
What is the share price of ProQR Therapeutics BV (PRQR)?
The closing price on Sep 22, 2026 was $1.90. Our model-based fair value is $0.3400, about −82% upside (overvalued). We carry closing prices from our data provider, not a live tick.
What should I pay attention to with ProQR Therapeutics BV right now?
The price sits above even our optimistic bull case ($0.4250). The favourable scenario is already priced in. Weak quality (27/100) and above fair value at the same time, the margin of safety is missing on both counts. The large gap to fair value rests on thin data (low evidence): fewer applicable models and a shorter history. Read it with extra caution. A fairly wide model range ($0.2210 to $0.4250) leaves room in how you read the outcome.

Key figures of ProQR Therapeutics BV

How large is the market capitalisation of ProQR Therapeutics BV (PRQR)?
The market capitalisation of ProQR Therapeutics BV is $200M. The stock-market value of the whole company: share price times number of shares. It is what the market asks for the entire business today.
What is the P/S ratio of ProQR Therapeutics BV (PRQR)?
The price-to-sales ratio of ProQR Therapeutics BV is 14.6 (last twelve months). Price to sales: market value relative to yearly revenue. Useful when profit is thin or distorted.
What are the earnings per share of ProQR Therapeutics BV (PRQR)?
Earnings per share at ProQR Therapeutics BV are $−0.5000. Earnings per share over the last twelve months: total profit spread across every single share.
What is the return on equity of ProQR Therapeutics BV (PRQR)?
The return on equity (ROE) of ProQR Therapeutics BV is −78.1% (last twelve months). Profit relative to shareholders' equity, how efficiently the company works with its owners' money.
What is the EBIT return on assets of ProQR Therapeutics BV (PRQR)?
On an EBIT basis the return on assets of ProQR Therapeutics BV is −28.4% (avg 5y). Operating profit (EBIT) relative to everything the company owns, as a multi-year average. It describes the business model rather than one good or bad year.
What is the operating margin of ProQR Therapeutics BV (PRQR)?
The operating margin of ProQR Therapeutics BV is −671% (last twelve months). Profit from the core business (before interest and taxes) relative to revenue.
How fast is revenue growing at ProQR Therapeutics BV (PRQR)?
Revenue at ProQR Therapeutics BV is growing −57.1% versus a year earlier (3y avg +62.0%). How much revenue grew versus a year earlier (YoY). The 3-year average next to it puts the single year in context.
How much free cash flow does ProQR Therapeutics BV (PRQR) generate?
The free cash flow of ProQR Therapeutics BV is −$51.7M (fiscal year 2025). The cash truly left after running and investing in the business, this is what pays dividends and buybacks.
How much net cash does ProQR Therapeutics BV (PRQR) hold?
ProQR Therapeutics BV holds more cash than debt, $78.4M net (fiscal year 2025). The company holds more cash than debt, a safety cushion.
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