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Spruce Biosciences, Inc. (SPRB) fair value: what the stock is really worth

As of Sep 23, 2026: fair value of Spruce Biosciences, Inc. $12.31, price $49.42, upside -75.1%, quality 39 out of 100. Calculated from audited financials with 26 valuation models and 37 quality factors, updated daily.

  1. Fair value above price? No
  2. Good quality? No
  3. Add to watchlist

Healthcare · US · ISIN US85209E2081

SB Spruce Biosciences, Inc. logo Thin data Sep 23, 2026

Spruce Biosciences, Inc.

SPRB · US

Weakest SetupStrongly overvalued and low quality.

!Fair value $12.31 · Strongly overvalued (−75%)
!Quality 39/100
!Weak Growth (revenue YoY −51.3 %/yr)
!Low debt · negative free cash flow
!Trails peers (3/8)
!Narrow moat 3/100
!Evidence only low, so the estimate is less certain
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What runs behind every stock

26 valuation models 8 families, DCF to NCAV 37 quality factors margins, balance sheet, cashflow, debt 6 AI factors moat, what no ratio measures 2,000+ data points verified, per stock, median

69 individual criteria per stock, every one traceable See the method →

Price vs Fair Value

$844.50 $4.50 Fair Value $12.31 Jun 2021 Sep 2026

White line = price, green steps = our fair value per fiscal year, dashed = 300-day average. As of Sep 23, 2026.

How to read this chart

60‑month range $4.50 – $844.50 · fair‑value band $8.12 – $15.39 · the $49.42 price screens above the $12.31 fair value. Green steps = our fair value per fiscal year (point-in-time, no hindsight). Dashed = 300-day average. As of Sep 23, 2026.

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Company profile

Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders. The company develops TA-ERT, a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase, which is an enzyme replacement therapy for patients with Sanfilippo Syndrome Type B.

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Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders. The company develops TA-ERT, a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase, which is an enzyme replacement therapy for patients with Sanfilippo Syndrome Type B. It also develops Tildacerfont for treating a highly debilitating mental disorder characterized by depressed mood with cognitive-affective and somatic changes, including anhedonia, weight alterations, and altered sleeping patterns. In addition, the company develops SPR202 for the treatment of Congenital Adrenal Hyperplasia (CAH), a chronic and potentially life-threatening rare disease with no cure. The company has a license agreement with Eli Lilly and Company to research, develop, and commercialize various pharmaceutical compounds. It also has a collaboration and license agreement with Kaken Pharmaceutical Co. Ltd. to develop, manufacture, and commercialize Tildacerfont for the treatment of CAH in Japan. Spruce Biosciences, Inc. was incorporated in 2014 and is headquartered in South San Francisco, California.

Stock analysis

Spruce Biosciences, Inc. Common Stock (SPRB) currently trades at $49.42, while our model-based Fair Value estimate is $12.31, implying the stock looks roughly 301.4% overvalued today.

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Valuation

How firm this estimate is: it rests on 1 models at a data quality of 96/100, which puts the evidence level at low.

Scenario range: $8.12 (bear) to $15.39 (bull), the price of $49.42 sits above it. Bear and bull are the same models on cautious and optimistic assumptions, a range, not a price target.

Quality & growth

The Quality Score stands at 39/100 (below-average quality), in the Healthcare sector.

Weak Growth: Revenue growth is weak, negative or inconsistent.

Spruce Biosciences, Inc. Common Stock reported revenue of $0 in FY2025 versus $0 in FY2021. Reported net income was −$39.0M in FY2025.

Key figures

Market cap $152M · EPS (TTM) $−38.43 · Return on equity −106% · Return on assets (EBIT) −66.3% · Revenue (TTM) $697K · Revenue growth (YoY) −75.9% · Free cash flow −$33.3M · Net cash $48.2M.

Competitive moat

Our AI-assisted moat analysis scores the competitive advantage at 22 out of 100 (low confidence).

What moves the price

The share trades about 73% below its 52-week high and 538% above its 52-week low, currently below its 200-day average.

For context, the median of 10 Healthcare peers we cover trades at −5% fair-value upside, at −75%, SPRB screens richer than that median.

Fair Value models

Bear $8.12 Fair Value $12.31 Bull $15.39
Model ⓘEach model values the company its own way (discounted cash flow, earnings, assets, dividends). The fair value above is their evidence-weighted blend, not the output of a single model. Bear ⓘBear = the cautious scenario: the same model computed with conservative anchors (lower growth, margins and valuation multiples). Together with Bull it frames a plausible valuation range, not a price target.BaseBull ⓘBull = the optimistic scenario: the same model computed with favourable anchors (higher growth, margins and valuation multiples). Together with Bear it frames a plausible valuation range, not a price target. Evidence ⓘEvidence = how well-backed THIS model's estimate is for this stock (0–100): how complete and reliable its input data are, and how well the model fits the company. The final Fair Value is an evidence-weighted blend, so better-evidenced models count more. Green ≥70, amber 50–69, grey below 50.
Highest evidence
NCAV (Graham) $7.40 $9.91 $14.79 54
All 1 models by family
Asset-Based
NCAV (Graham) $7.40 $9.91 $14.79 54

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Quality Score breakdown

Overall quality 39/100

Of which business quality 44 · Market factors (momentum, volatility) 39

Profitability 0
Margins and returns on capital today
Quality Growth 33
Are margins and returns improving?
Cashflow 62
Earnings quality: real cash, not paper profit
Fin. Strength 75
Balance sheet, leverage, solvency risk
Investment 100
Disciplined investing over empire-building
Low Volatility 0
Calm price path (market factor)
Momentum 51
Price trend over the last 3–12 months (market factor)
52W Momentum 62
Distance to the 52-week high (market factor)
Net Issuance 0
Share count: buybacks or dilution?

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Revenue & earnings trend

Growth Quality ⓘGrowth is valuable only when reinvestment earns attractive returns (Aswath Damodaran): sustainable growth depends on return on capital, reinvestment and efficiency. Basis: total company revenue over the periods shown on the cards (3Y/5Y/all years), not per share, so a merger can show up as a growth jump; per-share earnings growth is in the value-creation card. 0/100
Revenue growth is weak, negative or inconsistent.
What shareholders gained per year ⓘWe only publish this rate when it is defensible. Reason: fiscal 2025 is a loss year, no rate is defined from a loss
not computed

SPRB screens 301% overvalued. Compare with Vertex Pharmaceuticals Incorporated →

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Peer GroupⓘHow this stock ranks against its industry: the green marker is this stock, the band is the typical 25–75% peer range, and the tick is the median.Biotechnology · 650 stocks

Beats the industry median on 3/7 measures
A mixed picture versus its industry peers.
Valuation
Quality Score 44 · Above median
Fair Value upside −75% · Bottom 25%
Profitability
Return on assets −40% · Bottom 25%
Operating margin (TTM) 0% · Above median
Growth and dividend
Revenue growth −76% · Bottom 25%
Balance sheet
Debt / equity 0.00× · Lowest 25%

Valuation Multiplesvs Biotechnology median · lower = cheaper

P/B 3.59× · Priciest 25%

Strength profile in five axes (Snowflake)

VALUEFUTUREPASTHEALTHDIVIDEND
This stock
VALUEFUTUREPASTHEALTHDIVIDEND
Sector peers
VALUE (fair-value potential)0 · sector 0
FUTURE (revenue growth)0 · sector 0
PAST (return on equity)0 · sector 0
HEALTH (low debt)100 · sector 97
DIVIDEND (yield)0 · sector 23

VALUE 0: the price sits above our fair-value range.

Context: sector, industry, market

Values & ESG

Does this company touch areas you may want to avoid? The classification is inferred from sector and industry.

None of the checked exposures detected

Similar stocks

10 more Biotechnology stocks, each showing price versus our Fair Value estimate.

Stock Price Fair Value vs Fair Value
Vertex Pharmaceuticals Incorporated VRTX $516.34 $567.97 +10%
Regeneron Pharmaceuticals, Inc REGN $801.82 $1,252 +56%
argenx SE ARGX $963.79 $918.60 −5%
Samsung Biologics Co 207940 1,366,000 KRW 1,502,600 KRW +10%
CSL Limited CSL A$179.12 A$197.03 +10%
Alnylam Pharmaceuticals, Inc ALNY $251.65 $218.36 −13%
Royalty Pharma plc RPRX $58.52 $24.22 −59%
BeOne Medicines AG 6160 HK$218.20 HK$169.72 −22%
Celltrion, Inc 068270 177,400 KRW 74,519 KRW −58%
BioNTech SE BNTX $100.87 $63.62 −37%

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Spruce Biosciences, Inc. Common Stock · Fair Value
$12.31 −301%Fair Value
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Cite: Fair Value Calculator (2026). "Spruce Biosciences, Inc. Common Stock Fair Value". https://www.fairvalue-calculator.com/stock/SPRB

Frequently asked questions

Is Spruce Biosciences, Inc. (SPRB) overvalued or undervalued?
As of Sep 23, 2026, our model estimates a fair value of $12.31 versus a price of $49.42, about −75% upside (overvalued).
What is the fair value of SPRB?
Our model-based fair value for Spruce Biosciences, Inc. Common Stock is $12.31 (as of Sep 23, 2026), built from audited fundamentals. The current price: $49.42.
What is the quality score of SPRB?
Spruce Biosciences, Inc. Common Stock has a Quality Score of 39/100. It measures business quality (profitability, growth, cash flow, balance-sheet strength, investment discipline, share issuance). Market factors such as price momentum and volatility do not enter the number; they are shown separately in the detail view.
What is the price target for Spruce Biosciences, Inc. (SPRB)?
Our model-based price target is the fair value of $12.31 (as of Sep 23, 2026) from 1 valuation models. Cautious scenario $8.12, optimistic scenario $15.39. It is a calculation from audited fundamentals, not an analyst target.
What is the Spruce Biosciences, Inc. Common Stock stock forecast for 2026?
Our models put fair value at $12.31, about −75% upside versus a price of $49.42 (overvalued). Cautious scenario $8.12, optimistic scenario $15.39. The calculation is refreshed regularly with new filings.
What is the revenue of Spruce Biosciences, Inc. (SPRB)?
Spruce Biosciences, Inc. Common Stock reported trailing-twelve-month revenue of about $697K (latest available figure, as of Sep 23, 2026).
What is the intrinsic value of Spruce Biosciences, Inc. (SPRB)?
Intrinsic value and fair value mean the same thing: what the business is worth on its numbers, independent of the share price. For Spruce Biosciences, Inc. Common Stock it is $12.31 per share (as of Sep 23, 2026), against a price of $49.42. It is the blended result of 1 valuation models (cash flow, earnings, asset, dividend).
Is Spruce Biosciences, Inc. Common Stock stock overvalued or undervalued in 2026?
As of Sep 23, 2026, SPRB trades above its calculated fair value: price $49.42, fair value $12.31, a gap of about −75% (overvalued). The calculation is refreshed with each new quarterly report, so the verdict can change during the year.
Is fair value the same as the market price of SPRB?
No. The price is what the market pays today ($49.42); the fair value is what the company's own numbers justify ($12.31). For Spruce Biosciences, Inc. Common Stock the two are $37.11 per share apart. That gap is exactly why we show both numbers side by side.
How much is Spruce Biosciences, Inc. Common Stock worth?
The market values Spruce Biosciences, Inc. Common Stock at about $152M (market capitalisation, as of Sep 23, 2026). Per share that is $49.42; our models calculate a fair value of $12.31 per share.
What do the bullish and bearish scenarios say about SPRB?
Our models span a range for Spruce Biosciences, Inc. Common Stock: cautious scenario $8.12, base $12.31, optimistic $15.39 per share (as of Sep 23, 2026, price $49.42). The range comes from different growth and margin assumptions, not from analyst opinions.
How solid is the balance sheet of Spruce Biosciences, Inc. (SPRB)?
Balance-sheet figures for Spruce Biosciences, Inc. Common Stock (as of Sep 23, 2026): return on equity −106.0%, debt of 0.00 per unit of equity. They feed the Quality Score of 39/100, which measures business quality independently of the share price.
How far is SPRB from its 52-week high?
Spruce Biosciences, Inc. Common Stock trades at $49.42, about 73% below its 52-week high of $182.60 and 538% above the low of $7.75 (as of Sep 23, 2026). Distance from the high says nothing about value: that is what the fair value of $12.31 is for.
Which stocks are comparable to Spruce Biosciences, Inc. Common Stock?
From the same area (Healthcare) we also value Vertex Pharmaceuticals Incorporated, Regeneron Pharmaceuticals, Inc, argenx SE, Samsung Biologics Co, among others. Each of them has its own fair-value calculation on this site using the same models, so the comparison is like for like.
Is Spruce Biosciences, Inc. Common Stock stock attractive at the current price?
The data as of Sep 23, 2026: price $49.42, calculated fair value $12.31 (−75%), Quality Score 39/100, from 1 models. Whether that fits your horizon and risk tolerance is your call. We provide the calculation, not investment advice.
How is the fair value of SPRB calculated?
We run Spruce Biosciences, Inc. Common Stock through 1 models from four families: discounted cash flow, earnings models, asset and balance-sheet models, and dividend models. Every model gets the same audited fundamentals; the result is the weighted average of $12.31, with the spread shown as a cautious and an optimistic scenario.
Is it still worth investing in stocks now?
The global stock market currently sits 13.0 % above its aggregate fair value. Spruce Biosciences, Inc. Common Stock itself currently trades above fair value. An expensive market is no reason to stay out and no reason to buy everything at once: keep a broad savings plan running, buy single stocks only with money you can do without, and hold part of your money liquid while the market is high. The full picture including sectors is on is it worth investing now.
What is the share price of Spruce Biosciences, Inc. (SPRB)?
The closing price on Sep 23, 2026 was $49.42. Our model-based fair value is $12.31, about −75% upside (overvalued). We carry closing prices from our data provider, not a live tick.
What should I pay attention to with Spruce Biosciences, Inc. Common Stock right now?
The price sits above even our optimistic bull case ($15.39). The favourable scenario is already priced in. Weak quality (39/100) and above fair value at the same time, the margin of safety is missing on both counts. The large gap to fair value rests on thin data (low evidence): fewer applicable models and a shorter history. Read it with extra caution. A fairly wide model range ($8.12 to $15.39) leaves room in how you read the outcome.

Key figures of Spruce Biosciences, Inc. Common Stock

How large is the market capitalisation of Spruce Biosciences, Inc. (SPRB)?
The market capitalisation of Spruce Biosciences, Inc. Common Stock is $152M. The stock-market value of the whole company: share price times number of shares. It is what the market asks for the entire business today.
What are the earnings per share of Spruce Biosciences, Inc. (SPRB)?
Earnings per share at Spruce Biosciences, Inc. Common Stock are $−38.43. Earnings per share over the last twelve months: total profit spread across every single share.
What is the return on equity of Spruce Biosciences, Inc. (SPRB)?
The return on equity (ROE) of Spruce Biosciences, Inc. Common Stock is −106% (last twelve months). Profit relative to shareholders' equity, how efficiently the company works with its owners' money.
What is the EBIT return on assets of Spruce Biosciences, Inc. (SPRB)?
On an EBIT basis the return on assets of Spruce Biosciences, Inc. Common Stock is −66.3% (avg 5y). Operating profit (EBIT) relative to everything the company owns, as a multi-year average. It describes the business model rather than one good or bad year.
How fast is revenue growing at Spruce Biosciences, Inc. (SPRB)?
Revenue at Spruce Biosciences, Inc. Common Stock is growing −75.9% versus a year earlier. How much revenue grew versus a year earlier (YoY). The 3-year average next to it puts the single year in context.
How much free cash flow does Spruce Biosciences, Inc. (SPRB) generate?
The free cash flow of Spruce Biosciences, Inc. Common Stock is −$33.3M (fiscal year 2025). The cash truly left after running and investing in the business, this is what pays dividends and buybacks.
How much net cash does Spruce Biosciences, Inc. (SPRB) hold?
Spruce Biosciences, Inc. Common Stock holds more cash than debt, $48.2M net (fiscal year 2025). The company holds more cash than debt, a safety cushion.
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