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Bicycle Therapeutics Ltd (BCYC) fair value: what the stock is really worth

As of Nov 6, 2026: fair value (intrinsic value) of Bicycle Therapeutics Ltd stock $7.46, price $3.61, upside +106.6%, quality 38 out of 100. Rating: strongly undervalued. Calculated from audited financials with one of our 26 valuation models and 37 quality factors, updated daily.

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Healthcare US · Based in United Kingdom

BT Bicycle Therapeutics Ltd logo Thin data Nov 4, 2026

Bicycle Therapeutics Ltd

BCYC · US
Cheap, value-trap risk

The stock costs 52% less than our calculation considers fair.

Fair value $7.46 · Strongly undervalued
Low debt
Even on cautious assumptions the value is 36% above the price ($4.92).
Mixed Growth (revenue 5y +47.5 %/yr in USD)
Mixed vs. peers (4/8)
Insiders sold $122,983 (6M)
Quality 38/100
Negative free cash flow
Narrow moat 12/100
Thin data
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What runs behind every stock

69 individual criteria per stock, every one traceable See the method →

Price vs Fair Value

$61.14 $3.38 Fair Value $7.46 Aug 2021 Nov 2026

White line = price, green steps = our fair value per fiscal year. As of Nov 4, 2026.

How to read this chart

60‑month range $3.38 – $61.14 · fair‑value band $4.92 – $9.32 · the $3.61 price screens below the $7.46 fair value. Green steps = our fair value per fiscal year (point-in-time, no hindsight). As of Nov 4, 2026.

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Company profile

Bicycle Therapeutics plc, a clinical-stage pharmaceutical company, develops a class of medicines for diseases that are underserved by existing therapeutics in the United States and the United Kingdom.

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The company's products pipeline include zelenectide pevedotin, a bicycle toxin conjugate (BTC), which is in phase II clinical trials for the treatment of high nectin-4 expressing tumors; nuzefatide pevedotin (EphA2), a BTC that is in phase I/II clinical trials to treat Ephrin type A receptor 2 expressing tumor; BT7480, a Bicycle tumor-targeted immune cell agonist molecule, which is in phase I/II targeting nectin-4 and agonizing CD137; and BT1702, a theranostic BRC molecule targeting MT1-MMP for which IND-enabling activities are ongoing.

In addition, it develops Novel CNS targets, which is in preclinical trial targeting CNS disease; Novel neuromuscular targets, which is in preclinical trial targeting neuromuscular disease; and programs that are in preclinical trial targeting radiopharmaceutical.

Further, the company collaborates with biopharmaceutical companies and organizations to develop programs in therapeutic areas.

It has collaboration and license agreement with Bayer Consumer Care AG; Novartis Pharma AG; Ionis Pharmaceuticals, Inc.; Genentech, Inc; and AstraZeneca AB. Bicycle Therapeutics plc was incorporated in 2009 and is headquartered in Cambridge, the United Kingdom.

Stock analysis

Bicycle Therapeutics Ltd (BCYC) currently trades at $3.61, while our model-based Fair Value estimate is $7.46, implying the stock looks roughly 52% undervalued today.

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Valuation

How firm this estimate is: it rests on 1 models at a data quality of 96/100, which puts the data coverage at low.

Scenario range: $4.92 (bear) to $9.32 (bull), the price of $3.61 sits below it. Bear and bull are the same models on cautious and optimistic assumptions, a range, not a price target.

Quality & growth

The Quality Score stands at 38/100 (below-average quality), in the Healthcare sector.

Mixed Growth: Revenue is growing, but margins or cash flow do not fully confirm the trend.

Bicycle Therapeutics Ltd reported revenue of $72.6M in FY2025 versus $11.7M in FY2021, a compound +57.8%/yr. Reported net income was −$219M in FY2025.

Key figures

Market cap $252M Micro · P/S ratio 4.19 · EPS (TTM) $−2.03 · Return on equity −32.3% · Return on assets (EBIT) −26.1% (5-year average) · Operating margin −8,674% · Revenue (TTM) $61.2M · Revenue growth (YoY) −78.5%.

Competitive moat

Our AI-assisted moat analysis scores the competitive advantage at 12 out of 100 (medium confidence).

What moves the price

The share trades about 52% below its 52-week high and 7% above its 52-week low, currently below its 200-day average.

For context, the median of 10 Healthcare peers we cover trades at 10% fair-value upside, at 107%, BCYC screens cheaper than that median.

Fair Value models

Bear $4.92 Fair Value $7.46 Bull $9.32
Price $3.61 · Upside +106.6%
Model ⓘEach model values the company its own way (discounted cash flow, earnings, assets, dividends). The fair value above starts from their evidence-weighted blend, not from a single model. In cyclical trough or peak years, after dilution or a stock split it is adjusted afterwards, so it can sit above or below the models. Bear ⓘBear = the cautious scenario: the same model computed with conservative anchors (lower growth, margins and valuation multiples). Together with Bull it frames a plausible valuation range, not a price target.BaseBull ⓘBull = the optimistic scenario: the same model computed with favourable anchors (higher growth, margins and valuation multiples). Together with Bear it frames a plausible valuation range, not a price target. If a model's bull case is above four times its base value, the table shows that limit with a > sign (like the overall Bull above): beyond it no assumption holds. Coverage ⓘCoverage = how well-backed THIS model's estimate is for this stock (0–100): how complete and reliable its input data are, and how well the model fits the company. The final Fair Value is an evidence-weighted blend, so better-evidenced models count more. Green ≥70, amber 50–69, grey below 50.
Best data coverage
NCAV (Graham) $4.92 $7.46 $9.32 53
All 1 models by family
Asset-Based
NCAV (Graham) $4.92 $7.46 $9.32 53

Open the full fair value analysis →

Quality Score breakdown

Overall quality 38/100

It rates the business: profits, how they develop, real cash, balance sheet, investing and share count.

Profitability 4
How much profit the company makes from its sales and capital
Quality Growth 76
Are margins and returns getting better?
Cashflow 14
Do the profits arrive as real cash?
Financial strength 74
Debt, balance sheet and risk of trouble
Investment 31
Does it invest with discipline instead of growing at any price?
Low Volatility 16
How calm the share price moves, does not count
Price momentum 14
Price momentum of the last 3 to 12 months, does not count
Near the 52-week high 3
Distance to the 52-week high, does not count
New shares 36
Buys back shares or issues new ones?

Open the full quality analysis →

Insider trades

In the last 6 months, 6 officers or directors sold shares worth $122,983 and none bought.

  • SaleJennifer Scott PerryChief Operating Officer4× since Apr 2, 2026: 4,270 shares, avg. $4.25$18,152Oct 5, 202610b5-1 plan
  • SaleMichael SkynnerCHIEF SCIENTIFIC OFFICER4× since Jan 2, 2026: 13,551 shares, avg. $5.35$72,447Oct 5, 2026
  • SaleKevin LeeCHIEF EXECUTIVE OFFICER, Director4× since Jan 2, 2026: 44,444 shares, avg. $5.38$239,111Oct 5, 2026
  • SaleTravis Alvin ThompsonChief Financial Officer4× since Jan 2, 2026: 5,228 shares, avg. $5.34$27,912Oct 5, 2026
  • SaleMichael Charles Ferguson HannayCHIEF PROD & SUPPLY CHAIN OFF4× since Jan 2, 2026: 10,541 shares, avg. $5.41$57,075Oct 5, 2026
  • SaleRobert Charles SwantonDirector3,431 shares at $3.47$11,906Oct 2, 2026
  • SaleAlistair MilnesCHIEF OPERATING OFFICER6,660 shares at $6.63$44,127Jan 5, 2026
  • SaleAlethia YoungChief Financial Officer7,623 shares at $6.62$50,489Jan 5, 202610b5-1 plan

Sales are often planned (taxes, diversification, 10b5-1 plans). Purchases with their own money are seen as the stronger sign. For information only: not part of the quality score or Fair Value.

Source: SEC Form 4, as of Nov 6, 2026. All filings at the SEC ↗

Revenue & earnings trend

Growth Quality ⓘGrowth is valuable only when reinvestment earns attractive returns (Aswath Damodaran): sustainable growth depends on return on capital, reinvestment and efficiency. Basis: total company revenue over the periods shown on the cards (3Y/5Y/all years), not per share, so a merger can show up as a growth jump; per-share earnings growth is in the value-creation card. 35/100
Revenue is growing, but margins or cash flow do not fully confirm the trend.
Revenue growth 1 year
+105.8%
Revenue growth 3 years ⓘMeasures the company's TOTAL revenue from reported annual statements: compound average growth per year (CAGR) from the fiscal year 3, 5 or N years back to the most recent comparable fiscal year. Not per share: buybacks do not change this number, and a merger can appear as a growth jump. Per-share growth (which does include buybacks) is in the value-creation card.
+71.2%
Revenue growth 5 years ⓘMeasures the company's TOTAL revenue from reported annual statements: compound average growth per year (CAGR) from the fiscal year 3, 5 or N years back to the most recent comparable fiscal year. Not per share: buybacks do not change this number, and a merger can appear as a growth jump. Per-share growth (which does include buybacks) is in the value-creation card.
+47.5%
Start year 2020 (pandemic)
Revenue growth 8 years ⓘMeasures the company's TOTAL revenue from reported annual statements: compound average growth per year (CAGR) from the fiscal year 3, 5 or N years back to the most recent comparable fiscal year. Not per share: buybacks do not change this number, and a merger can appear as a growth jump. Per-share growth (which does include buybacks) is in the value-creation card.
+56.1%
Profit margin (trend) ⓘOperating margin then vs now, from reported annual statements. A falling margin after a boom year is the classic peak-earnings signal: the growth rate then leans on an inflated base.
−500.1% (2020) → −341.3% (2025)
What shareholders gained per year ⓘWe only publish this rate when it is defensible. Reason: fiscal 2025 is a loss year, no rate is defined from a loss
not computed

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Peer GroupⓘHow this stock ranks against its industry: the green marker is this stock, the band is the typical 25–75% peer range, and the tick is the median.Biotechnology · 558 stocks

Beats the industry median on 4/7 measures
A mixed picture versus its industry peers.
Valuation
Quality Score 38 · Below median
Fair Value upside +106.6% · Top 25%
Profitability
Return on assets −30.5% · Below median
Growth and dividend
Revenue growth (quarter YoY) −78.5% · Bottom 25%
Balance sheet
Debt / equity 0.05× · Below median

Valuation Multiplesvs Biotechnology median · lower = cheaper

P/B 0.41× · Cheapest 25%
P/S (12 months) 4.12× · Cheaper than median

Strength profile in five axes (Snowflake)

VALUEFUTUREPASTHEALTHDIVIDEND
This stock
VALUEFUTUREPASTHEALTHDIVIDEND
Sector peers
VALUE (fair-value potential)100 · sector 0
FUTURE (revenue growth)0 · sector 0
PAST (return on equity)0 · sector 0
HEALTH (low debt)98 · sector 97
DIVIDEND (yield)0 · sector 22

Context: sector, industry, market

Values & ESG

Does this company touch areas you may want to avoid? The classification is inferred from sector and industry.

None of the checked exposures detected

Similar stocks

10 more Biotechnology stocks, each showing price versus our Fair Value estimate.

Stock Price Fair Value vs Fair Value Compare
Incyte Corporation INCY $119.65 $199.23 +67% vs BCYC
Regeneron Pharmaceuticals, Inc REGN $904.35 $1,275 +41% vs BCYC
Vertex Pharmaceuticals Incorporated VRTX $547.09 $601.80 +10% vs BCYC
Samsung Biologics Co 207940 1,516,000 KRW 1,667,600 KRW +10% vs BCYC
Genmab A/S GMAB kr 3,527 kr 3,880 +10% vs BCYC
WuXi Biologics (Cayman) Inc 2269 HK$47.62 HK$52.38 +10% vs BCYC
argenx SE ARGX $927.21 $908.40 −2% vs BCYC
CSL Limited CSL A$200.77 A$183.04 −9% vs BCYC
Celltrion, Inc 068270 211,000 KRW 74,945 KRW −64% vs BCYC
Royalty Pharma plc RPRX $67.30 $19.01 −72% vs BCYC

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Bicycle Therapeutics Ltd: fair value per Fair Value Calculator

Cite: Fair Value Calculator (2026). "Bicycle Therapeutics Ltd Fair Value". https://www.fairvalue-calculator.com/stock/BCYC

Frequently asked questions

Is Bicycle Therapeutics Ltd (BCYC) overvalued or undervalued?
As of Nov 4, 2026, our model estimates a fair value of $7.46 versus a price of $3.61, about +107% upside (undervalued).
What is the fair value of BCYC?
Our model-based fair value for Bicycle Therapeutics Ltd is $7.46 (as of Nov 4, 2026), built from audited fundamentals. The current price: $3.61.
What is the quality score of BCYC?
Bicycle Therapeutics Ltd has a Quality Score of 38/100. It measures business quality (profitability, growth, cash flow, balance-sheet strength, investment discipline, share issuance). Market factors such as price momentum and volatility do not enter the number; they are shown separately in the detail view.
What is the price target for Bicycle Therapeutics Ltd (BCYC)?
Our model-based price target is the fair value of $7.46 (as of Nov 4, 2026) from 1 valuation models. Cautious scenario $4.92, optimistic scenario $9.32. It is a calculation from audited fundamentals, not an analyst target.
What is the Bicycle Therapeutics Ltd stock forecast for 2026?
Our models put fair value at $7.46, about +107% upside versus a price of $3.61 (undervalued). Cautious scenario $4.92, optimistic scenario $9.32. The calculation is refreshed regularly with new filings.
What is the revenue of Bicycle Therapeutics Ltd (BCYC)?
Bicycle Therapeutics Ltd reported trailing-twelve-month revenue of about $61.2M (latest available figure, as of Nov 4, 2026).
What is the intrinsic value of Bicycle Therapeutics Ltd (BCYC)?
Intrinsic value and fair value mean the same thing: what the business is worth on its numbers, independent of the share price. For Bicycle Therapeutics Ltd it is $7.46 per share (as of Nov 4, 2026), against a price of $3.61. It is the blended result of 1 valuation models in 1 family (Asset-Based).
Is Bicycle Therapeutics Ltd stock overvalued or undervalued in 2026?
As of Nov 4, 2026, BCYC trades below its calculated fair value: price $3.61, fair value $7.46, a gap of about +107% (undervalued). The calculation is refreshed with each new quarterly report, so the verdict can change during the year.
Is fair value the same as the market price of BCYC?
No. The price is what the market pays today ($3.61); the fair value is what the company's own numbers justify ($7.46). For Bicycle Therapeutics Ltd the two are $3.85 per share apart. That gap is exactly why we show both numbers side by side.
How much is Bicycle Therapeutics Ltd worth?
The market values Bicycle Therapeutics Ltd at about $252M (market capitalisation, as of Nov 4, 2026). Per share that is $3.61; our models calculate a fair value of $7.46 per share.
What do the bullish and bearish scenarios say about BCYC?
Our models span a range for Bicycle Therapeutics Ltd: cautious scenario $4.92, base $7.46, optimistic $9.32 per share (as of Nov 4, 2026, price $3.61). The range comes from different growth and margin assumptions, not from analyst opinions.
How solid is the balance sheet of Bicycle Therapeutics Ltd (BCYC)?
Balance-sheet figures for Bicycle Therapeutics Ltd (as of Nov 4, 2026): return on equity −32.3%, debt of 0.05 per unit of equity. They feed the Quality Score of 38/100, which measures business quality independently of the share price.
How far is BCYC from its 52-week high?
Bicycle Therapeutics Ltd trades at $3.61, about 52% below its 52-week high of $7.52 and 7% above the low of $3.38 (as of Nov 6, 2026). Distance from the high says nothing about value: that is what the fair value of $7.46 is for.
Which stocks are comparable to Bicycle Therapeutics Ltd?
From the same area (Healthcare) we also value Vertex Pharmaceuticals Incorporated, Regeneron Pharmaceuticals, Inc, CSL Limited, argenx SE, among others. Each of them has its own fair-value calculation on this site using the same models, so the comparison is like for like.
Is Bicycle Therapeutics Ltd stock attractive at the current price?
The data as of Nov 4, 2026: price $3.61, calculated fair value $7.46 (+107%), Quality Score 38/100, from 1 models. Whether that fits your horizon and risk tolerance is your call. We provide the calculation, not investment advice.
How is the fair value of BCYC calculated?
We run Bicycle Therapeutics Ltd through 1 models from 1 family: Asset-Based. Every model gets the same audited fundamentals; the fair value of $7.46 builds on their evidence-weighted average, with the spread shown as a cautious and an optimistic scenario.
Is it still worth investing in stocks now?
The global stock market currently sits 13.3% above its aggregate fair value. Bicycle Therapeutics Ltd currently trades 52% below its own fair value, and the market average says nothing about that. An expensive market is no reason to stay out and no reason to buy everything at once: keep a broad savings plan running, buy single stocks only with money you can do without, and hold part of your money liquid while the market is high. The full picture including sectors is on is it worth investing now.
What is the share price of Bicycle Therapeutics Ltd (BCYC)?
The closing price on Nov 6, 2026 was $3.61. Our model-based fair value is $7.46, about +107% upside (undervalued). We carry closing prices from our data provider, not a live tick.
What should I pay attention to with Bicycle Therapeutics Ltd right now?
The large discount to fair value meets weak quality (38/100). That raises the risk this is a value trap rather than a bargain. The price is below even our cautious bear case ($4.92). The market is more pessimistic than our downside scenario. The large gap to fair value rests on thin data (low evidence): fewer applicable models and a shorter history. Read it with extra caution. A fairly wide model range ($4.92 to $9.32) leaves room in how you read the outcome.

Key figures of Bicycle Therapeutics Ltd

How large is the market capitalisation of Bicycle Therapeutics Ltd (BCYC)?
The market capitalisation of Bicycle Therapeutics Ltd is $252M. The stock-market value of the whole company: share price times number of shares. It is what the market asks for the entire business today.
What is the P/S ratio of Bicycle Therapeutics Ltd (BCYC)?
The price-to-sales ratio of Bicycle Therapeutics Ltd is 4.19 (last twelve months). Price to sales: market value relative to yearly revenue. Useful when profit is thin or distorted.
What are the earnings per share of Bicycle Therapeutics Ltd (BCYC)?
Earnings per share at Bicycle Therapeutics Ltd are $−2.03. Earnings per share over the last twelve months: total profit spread across every single share.
What is the return on equity of Bicycle Therapeutics Ltd (BCYC)?
The return on equity (ROE) of Bicycle Therapeutics Ltd is −32.3% (last twelve months). Profit relative to shareholders' equity, how efficiently the company works with its owners' money.
What is the EBIT return on assets of Bicycle Therapeutics Ltd (BCYC)?
On an EBIT basis the return on assets of Bicycle Therapeutics Ltd is −26.1% (avg 5y). Operating profit (EBIT) relative to everything the company owns, as a multi-year average. It describes the business model rather than one good or bad year.
What is the operating margin of Bicycle Therapeutics Ltd (BCYC)?
The operating margin of Bicycle Therapeutics Ltd is −8,674% (last twelve months). Profit from the core business (before interest and taxes) relative to revenue.
How fast is revenue growing at Bicycle Therapeutics Ltd (BCYC)?
Revenue at Bicycle Therapeutics Ltd is growing −78.5% versus a year earlier (3y avg +71.2%). How much revenue grew versus a year earlier (YoY). The 3-year average next to it puts the single year in context.
How much free cash flow does Bicycle Therapeutics Ltd (BCYC) generate?
The free cash flow of Bicycle Therapeutics Ltd is −$253M (fiscal year 2025). The cash truly left after running and investing in the business, this is what pays dividends and buybacks.
How much net cash does Bicycle Therapeutics Ltd (BCYC) hold?
Bicycle Therapeutics Ltd holds more cash than debt, $611M net (fiscal year 2025). The company holds more cash than debt, a safety cushion.
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