Bicycle Therapeutics Ltd (BCYC) fair value: what the stock is really worth
As of Nov 6, 2026: fair value (intrinsic value) of Bicycle Therapeutics Ltd stock $7.46, price $3.61, upside +106.6%, quality 38 out of 100. Rating: strongly undervalued. Calculated from audited financials with one of our 26 valuation models and 37 quality factors, updated daily.
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Bicycle Therapeutics Ltd
BCYC · USThe stock costs 52% less than our calculation considers fair.
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Price vs Fair Value
White line = price, green steps = our fair value per fiscal year. As of Nov 4, 2026.
How to read this chart
60‑month range $3.38 – $61.14 · fair‑value band $4.92 – $9.32 · the $3.61 price screens below the $7.46 fair value. Green steps = our fair value per fiscal year (point-in-time, no hindsight). As of Nov 4, 2026.
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Company profile
Bicycle Therapeutics plc, a clinical-stage pharmaceutical company, develops a class of medicines for diseases that are underserved by existing therapeutics in the United States and the United Kingdom.
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The company's products pipeline include zelenectide pevedotin, a bicycle toxin conjugate (BTC), which is in phase II clinical trials for the treatment of high nectin-4 expressing tumors; nuzefatide pevedotin (EphA2), a BTC that is in phase I/II clinical trials to treat Ephrin type A receptor 2 expressing tumor; BT7480, a Bicycle tumor-targeted immune cell agonist molecule, which is in phase I/II targeting nectin-4 and agonizing CD137; and BT1702, a theranostic BRC molecule targeting MT1-MMP for which IND-enabling activities are ongoing.
In addition, it develops Novel CNS targets, which is in preclinical trial targeting CNS disease; Novel neuromuscular targets, which is in preclinical trial targeting neuromuscular disease; and programs that are in preclinical trial targeting radiopharmaceutical.
Further, the company collaborates with biopharmaceutical companies and organizations to develop programs in therapeutic areas.
It has collaboration and license agreement with Bayer Consumer Care AG; Novartis Pharma AG; Ionis Pharmaceuticals, Inc.; Genentech, Inc; and AstraZeneca AB. Bicycle Therapeutics plc was incorporated in 2009 and is headquartered in Cambridge, the United Kingdom.
Stock analysis
Bicycle Therapeutics Ltd (BCYC) currently trades at $3.61, while our model-based Fair Value estimate is $7.46, implying the stock looks roughly 52% undervalued today.
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Valuation
How firm this estimate is: it rests on 1 models at a data quality of 96/100, which puts the data coverage at low.
Scenario range: $4.92 (bear) to $9.32 (bull), the price of $3.61 sits below it. Bear and bull are the same models on cautious and optimistic assumptions, a range, not a price target.
Quality & growth
The Quality Score stands at 38/100 (below-average quality), in the Healthcare sector.
Mixed Growth: Revenue is growing, but margins or cash flow do not fully confirm the trend.
Bicycle Therapeutics Ltd reported revenue of $72.6M in FY2025 versus $11.7M in FY2021, a compound +57.8%/yr. Reported net income was −$219M in FY2025.
Key figures
Market cap $252M Micro · P/S ratio 4.19 · EPS (TTM) $−2.03 · Return on equity −32.3% · Return on assets (EBIT) −26.1% (5-year average) · Operating margin −8,674% · Revenue (TTM) $61.2M · Revenue growth (YoY) −78.5%.
Competitive moat
Our AI-assisted moat analysis scores the competitive advantage at 12 out of 100 (medium confidence).
What moves the price
The share trades about 52% below its 52-week high and 7% above its 52-week low, currently below its 200-day average.
For context, the median of 10 Healthcare peers we cover trades at 10% fair-value upside, at 107%, BCYC screens cheaper than that median.
Fair Value models
All 1 models by family
Quality Score breakdown
It rates the business: profits, how they develop, real cash, balance sheet, investing and share count.
Insider trades
In the last 6 months, 6 officers or directors sold shares worth $122,983 and none bought.
- SaleJennifer Scott PerryChief Operating Officer4× since Apr 2, 2026: 4,270 shares, avg. $4.25$18,152Oct 5, 202610b5-1 plan
- SaleMichael SkynnerCHIEF SCIENTIFIC OFFICER4× since Jan 2, 2026: 13,551 shares, avg. $5.35$72,447Oct 5, 2026
- SaleKevin LeeCHIEF EXECUTIVE OFFICER, Director4× since Jan 2, 2026: 44,444 shares, avg. $5.38$239,111Oct 5, 2026
- SaleTravis Alvin ThompsonChief Financial Officer4× since Jan 2, 2026: 5,228 shares, avg. $5.34$27,912Oct 5, 2026
- SaleMichael Charles Ferguson HannayCHIEF PROD & SUPPLY CHAIN OFF4× since Jan 2, 2026: 10,541 shares, avg. $5.41$57,075Oct 5, 2026
- SaleRobert Charles SwantonDirector3,431 shares at $3.47$11,906Oct 2, 2026
- SaleAlistair MilnesCHIEF OPERATING OFFICER6,660 shares at $6.63$44,127Jan 5, 2026
- SaleAlethia YoungChief Financial Officer7,623 shares at $6.62$50,489Jan 5, 202610b5-1 plan
Sales are often planned (taxes, diversification, 10b5-1 plans). Purchases with their own money are seen as the stronger sign. For information only: not part of the quality score or Fair Value.
Source: SEC Form 4, as of Nov 6, 2026. All filings at the SEC ↗
Revenue & earnings trend
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Compare Bicycle Therapeutics Ltd with another stock
Price, fair value, quality and upside side by side.
Peer GroupⓘHow this stock ranks against its industry: the green marker is this stock, the band is the typical 25–75% peer range, and the tick is the median.Biotechnology · 558 stocks
Valuation Multiplesvs Biotechnology median · lower = cheaper
Strength profile in five axes (Snowflake)
Context: sector, industry, market
- Is the Health Care sector expensive or cheap?
- P/E, EV/EBITDA and margins by industry (reference tables)
- Quality Score by industry
- Return on equity by industry
- Piotroski F-Score screener with fair value
- Undervalued stocks: US Stocks
- Valuation of the USA market
Values & ESG
Does this company touch areas you may want to avoid? The classification is inferred from sector and industry.
Similar stocks
10 more Biotechnology stocks, each showing price versus our Fair Value estimate.
| Stock | Price | Fair Value | vs Fair Value | Compare |
|---|---|---|---|---|
| Incyte Corporation INCY | $119.65 | $199.23 | +67% | vs BCYC |
| Regeneron Pharmaceuticals, Inc REGN | $904.35 | $1,275 | +41% | vs BCYC |
| Vertex Pharmaceuticals Incorporated VRTX | $547.09 | $601.80 | +10% | vs BCYC |
| Samsung Biologics Co 207940 | 1,516,000 KRW | 1,667,600 KRW | +10% | vs BCYC |
| Genmab A/S GMAB | kr 3,527 | kr 3,880 | +10% | vs BCYC |
| WuXi Biologics (Cayman) Inc 2269 | HK$47.62 | HK$52.38 | +10% | vs BCYC |
| argenx SE ARGX | $927.21 | $908.40 | −2% | vs BCYC |
| CSL Limited CSL | A$200.77 | A$183.04 | −9% | vs BCYC |
| Celltrion, Inc 068270 | 211,000 KRW | 74,945 KRW | −64% | vs BCYC |
| Royalty Pharma plc RPRX | $67.30 | $19.01 | −72% | vs BCYC |
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Key figures of Bicycle Therapeutics Ltd
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