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Uniqure NV (QURE) fair value: what the stock is really worth

As of Nov 10, 2026: fair value (intrinsic value) of Uniqure NV stock $13.97, price $22.71, that is 38.5% below the price, quality 26 out of 100. Rating: strongly overvalued. The value is an estimate: none of our valuation models currently carries, it draws on revenue and assets compared with similar companies. Updated daily.

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Healthcare US · Based in Netherlands · ISIN NL0010696654

UN Uniqure NV logo Thin data Nov 10, 2026

Uniqure NV

QURE · US
Very expensive, weak quality

Our calculation puts a fair price 38% below what the stock costs today.

Low debt
Insiders sold $17.0M (6M)
Fair value $13.97 · Strongly overvalued
Quality 26/100
Weak Growth (revenue 5y −15.6 %/yr in USD)
Negative free cash flow
Trails peers (1/8)
Narrow moat 16/100
Thin data
Estimate
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What runs behind every stock

26 valuation models 8 families, DCF to NCAV 37 quality factors margins, balance sheet, cashflow, debt 6 AI factors moat, what no ratio measures 2,000+ data points verified, per stock, median

69 individual criteria per stock, every one traceable See the method →

Price vs Fair Value

$70.59 $3.78 Fair Value $13.97 Aug 2021 Nov 2026

White line = price, green steps = our fair value per fiscal year. As of Nov 10, 2026.

How to read this chart

60‑month range $3.78 – $70.59 · fair‑value band $10.48 – $17.46 · the $22.71 price screens above the $13.97 fair value. Green steps = our fair value per fiscal year (point-in-time, no hindsight). As of Nov 10, 2026.

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Company profile

uniQure N.V. develops treatments for patients suffering from rare and other devastating diseases in the United States. The company offers HEMGENIX that allows people living with hemophilia B to produce factor IX, which can lower the risk of bleeding.

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Its lead product candidate is AMT-130, a gene therapy candidate, which is in Phase I/II clinical study for the treatment of Huntington's disease.

The company also develops AMT-260, which is in Phase I/IIa clinical trial for the treatment of mesial temporal lobe epilepsy; AMT-162, which is in Phase I/IIa clinical trial to treat superoxide dismutase enzyme-amyotrophic lateral sclerosis; and AMT-191, an investigational gene therapy candidate which is in phase I/IIa clinical trial for the treatment of fabry disease.

It has a licensing agreement with Apic Bio to develop, manufacture, and commercialize intrathecally administered investigational gene therapy for ALS caused by mutations in SOD-1; and development and commercial supply agreement with CLS Bhering. uniQure N.V. was founded in 1998 and is headquartered in Amsterdam, the Netherlands.

Stock analysis

Uniqure NV (QURE) currently trades at $22.71, while our estimate is $13.97, 38% below the price, so the stock looks overvalued today.

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Valuation

None of our valuation models currently carries for this company, usually because of losses or heavy investment. The estimate draws on revenue and assets compared with similar companies and is less precise than a model-based fair value.

Scenario range: $10.48 (bear) to $17.46 (bull), the price of $22.71 sits above it. Bear and bull are the same models on cautious and optimistic assumptions, a range, not a price target.

Quality & growth

The Quality Score stands at 26/100 (below-average quality), in the Healthcare sector.

Weak Growth: Revenue is shrinking: the last year, the last three and the last five years are all negative.

Uniqure NV reported revenue of $16.1M in FY2025 versus $524M in FY2021, a compound −58.1%/yr. Reported net income was −$199M in FY2025.

Key figures

Market cap $1.5B Small · P/S ratio 85.6 · EPS (TTM) $−3.51 · Return on equity −158% · Return on assets (EBIT) −14.4% (5-year average) · Operating margin −872% · Revenue (TTM) $18.7M · Revenue growth (YoY) +11.0%.

Competitive moat

Our AI-assisted moat analysis scores the competitive advantage at 16 out of 100 (medium confidence).

What moves the price

The share trades about 56% below its 52-week high and 151% above its 52-week low, currently below its 200-day average.

For context, the median of 10 Healthcare peers we cover trades at −7% fair-value upside, at −38%, QURE screens richer than that median.

Fair Value

Bear $10.48 Fair Value $13.97 Bull $17.46
Price $22.71 · Downside -38.5%
Estimate. None of our valuation models currently carries for this company, usually because of losses or heavy investment. The estimate draws on revenue and assets compared with similar companies and is less precise than a model-based fair value.

Quality Score breakdown

Overall quality 26/100

It rates the business: profits, how they develop, real cash, balance sheet, investing and share count.

Profitability 1
How much profit the company makes from its sales and capital
Quality Growth 47
Are margins and returns getting better?
Cashflow 9
Do the profits arrive as real cash?
Financial strength 36
Debt, balance sheet and risk of trouble
Investment 90
Does it invest with discipline instead of growing at any price?
Low Volatility 26
How calm the share price moves, does not count
Price momentum 6
Price momentum of the last 3 to 12 months, does not count
Near the 52-week high 23
Distance to the 52-week high, does not count
New shares 0
Buys back shares or issues new ones?

Open the full quality analysis →

Insider trades

In the last 6 months, 11 officers or directors sold shares worth $17.0M and none bought.

  • SaleDavid D. MeekDirector2× since Jun 11, 2026: 11,073 shares, avg. $22.30$246,881Nov 6, 2026
  • SaleMatthew C KapustaCEO, Managing Director, Director6× since Feb 25, 2026: 323,990 shares, avg. $39.71$12.9MJul 2, 2026
  • SaleJack KayeDirector5× since Jan 9, 2026: 37,490 shares, avg. $40.44$1.5MJun 30, 2026
  • SaleWalid Abi-SaabChief Medical Officer5× since Mar 2, 2026: 78,902 shares, avg. $33.09$2.6MJun 30, 2026
  • SaleMadhavan BalachandranDirector3× since Jun 11, 2026: 23,678 shares, avg. $36.27$858,915Jun 17, 2026
  • SaleJeannette PottsChief Legal Officer3× since Mar 2, 2026: 17,227 shares, avg. $15.16$261,172Jun 15, 2026
  • SaleRachelle Suzanne JacquesDirector1,993 shares at $27.06$53,931Jun 11, 2026
  • SaleLeonard E PostDirector1,993 shares at $27.06$53,931Jun 11, 2026
  • SaleJeremy P. SpringhornDirector1,993 shares at $27.06$53,931Jun 11, 2026
  • SaleKylie O'KeefeChief Customer & Strat Officer15,936 shares at $27.06$431,228Jun 11, 2026

Plus 2 more entries from the last 12 months.

Plus 17 other filings such as grants, option exercises or tax withholding. They are not market purchases or sales.

Sales are often planned (taxes, diversification, 10b5-1 plans). Purchases with their own money are seen as the stronger sign. For information only: not part of the quality score or Fair Value.

Source: SEC Form 4, as of Nov 10, 2026. All filings at the SEC ↗

Revenue & earnings trend

Growth Quality ⓘGrowth is valuable only when reinvestment earns attractive returns (Aswath Damodaran): sustainable growth depends on return on capital, reinvestment and efficiency. Basis: total company revenue over the periods shown on the cards (3Y/5Y/all years), not per share, so a merger can show up as a growth jump; per-share earnings growth is in the value-creation card. 0/100
Revenue is shrinking: the last year, the last three and the last five years are all negative.
Revenue growth 1 year
−40.6%
Revenue growth 3 years ⓘMeasures the company's TOTAL revenue from reported annual statements: compound average growth per year (CAGR) from the fiscal year 3, 5 or N years back to the most recent comparable fiscal year. Not per share: buybacks do not change this number, and a merger can appear as a growth jump. Per-share growth (which does include buybacks) is in the value-creation card.
−46.7%
Revenue growth 5 years ⓘMeasures the company's TOTAL revenue from reported annual statements: compound average growth per year (CAGR) from the fiscal year 3, 5 or N years back to the most recent comparable fiscal year. Not per share: buybacks do not change this number, and a merger can appear as a growth jump. Per-share growth (which does include buybacks) is in the value-creation card.
−15.6%
Start year 2020 (pandemic). Over 10 years: +4.6% a year
Revenue growth 12 years ⓘMeasures the company's TOTAL revenue from reported annual statements: compound average growth per year (CAGR) from the fiscal year 3, 5 or N years back to the most recent comparable fiscal year. Not per share: buybacks do not change this number, and a merger can appear as a growth jump. Per-share growth (which does include buybacks) is in the value-creation card.
+12.2%
Profit margin (trend) ⓘOperating margin then vs now, from reported annual statements. A falling margin after a boom year is the classic peak-earnings signal: the growth rate then leans on an inflated base.
−334.3% (2020) → −1,166.8% (2025)
What shareholders gained per year ⓘWe only publish this rate when it is defensible. Reason: fiscal 2025 is a loss year, no rate is defined from a loss
not computed

QURE screens overvalued: fair value 38% below the price. Compare with Vertex Pharmaceuticals Incorporated →

Compare Uniqure NV with another stock

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Peer GroupⓘHow this stock ranks against its industry: the green marker is this stock, the band is the typical 25–75% peer range, and the tick is the median.Biotechnology · 849 stocks

Beats the industry median on 1/7 measures
Overall it trails its industry peers.
Valuation
Quality Score 26 · Bottom 25%
Fair Value upside −38.5% · Below median
Profitability
Return on assets −24.1% · Below median
Growth and dividend
Revenue growth (quarter YoY) 11.0% · Above median
Balance sheet
Debt / equity 0.25× · Above median

Valuation Multiplesvs Biotechnology median · lower = cheaper

P/B 7.56× · Priciest 25%
P/S (12 months) 80.57× · Priciest 25%

Strength profile in five axes (Snowflake)

VALUEFUTUREPASTHEALTHDIVIDEND
This stock
VALUEFUTUREPASTHEALTHDIVIDEND
Sector peers
VALUE (fair-value potential)0 · sector 0
FUTURE (revenue growth)55 · sector 0
PAST (return on equity)0 · sector 0
HEALTH (low debt)88 · sector 96
DIVIDEND (yield)0 · sector 20

VALUE 0: the price sits above our fair-value range.

Context: sector, industry, market

Values & ESG

Does this company touch areas you may want to avoid? The classification is inferred from sector and industry.

None of the checked exposures detected

Similar stocks

10 more Biotechnology stocks, each showing price versus our Fair Value estimate.

Stock Price Fair Value vs Fair Value Compare
Regeneron Pharmaceuticals, Inc REGN $916.06 $1,275 +39% vs QURE
Samsung Biologics Co 207940 1,468,000 KRW 1,661,000 KRW +13% vs QURE
Vertex Pharmaceuticals Incorporated VRTX $547.89 $601.80 +10% vs QURE
Genmab A/S GMAB kr 3,581 kr 3,880 +8% vs QURE
argenx SE ARGX $971.55 $908.40 −7% vs QURE
CSL Limited CSL A$201.68 A$181.40 −10% vs QURE
Moderna, Inc MRNA $250.83 $158.70 −37% vs QURE
BeOne Medicines AG 6160 HK$252.20 HK$152.80 −39% vs QURE
Celltrion, Inc 068270 203,000 KRW 74,945 KRW −63% vs QURE
Royalty Pharma plc RPRX $69.45 $19.01 −73% vs QURE

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Uniqure NV: fair value per Fair Value Calculator

Cite: Fair Value Calculator (2026). "Uniqure NV Fair Value". https://www.fairvalue-calculator.com/stock/QURE

Frequently asked questions

Is Uniqure NV (QURE) overvalued or undervalued?
As of Nov 10, 2026, our estimate of fair value is $13.97 versus a price of $22.71, about 38% lower (overvalued).
What is the fair value of QURE?
Our estimate for Uniqure NV is $13.97 (as of Nov 10, 2026), built from audited fundamentals. The current price: $22.71.
What is the quality score of QURE?
Uniqure NV has a Quality Score of 26/100. It measures business quality (profitability, growth, cash flow, balance-sheet strength, investment discipline, share issuance). Market factors such as price momentum and volatility do not enter the number; they are shown separately in the detail view.
What is the price target for Uniqure NV (QURE)?
Our calculated price target is the estimate of $13.97 (as of Nov 10, 2026). Cautious scenario $10.48, optimistic scenario $17.46. It is an estimate from revenue and assets compared with similar companies, because none of our valuation models currently carries, not an analyst target.
What is the Uniqure NV stock forecast for 2026?
Our estimate puts fair value at $13.97, about 38% lower versus a price of $22.71 (overvalued). Cautious scenario $10.48, optimistic scenario $17.46. The calculation is refreshed regularly with new filings.
What is the revenue of Uniqure NV (QURE)?
Uniqure NV reported trailing-twelve-month revenue of about $18.7M (latest available figure, as of Nov 10, 2026).
What is the intrinsic value of Uniqure NV (QURE)?
Intrinsic value and fair value mean the same thing: what the business is worth on its numbers, independent of the share price. For Uniqure NV it is $13.97 per share (as of Nov 10, 2026), against a price of $22.71.
Is Uniqure NV stock overvalued or undervalued in 2026?
As of Nov 10, 2026, QURE trades above its calculated fair value: price $22.71, fair value $13.97, a gap of about −38% (overvalued). The calculation is refreshed with each new quarterly report, so the verdict can change during the year.
Is fair value the same as the market price of QURE?
No. The price is what the market pays today ($22.71); the fair value is what the company's own numbers justify ($13.97). For Uniqure NV the two are $8.74 per share apart. That gap is exactly why we show both numbers side by side.
How much is Uniqure NV worth?
The market values Uniqure NV at about $1.5B (market capitalisation, as of Nov 10, 2026). Per share that is $22.71; our models calculate a fair value of $13.97 per share.
What do the bullish and bearish scenarios say about QURE?
Our models span a range for Uniqure NV: cautious scenario $10.48, base $13.97, optimistic $17.46 per share (as of Nov 10, 2026, price $22.71). The range comes from different growth and margin assumptions, not from analyst opinions.
How solid is the balance sheet of Uniqure NV (QURE)?
Balance-sheet figures for Uniqure NV (as of Nov 10, 2026): return on equity −157.6%, debt of 0.25 per unit of equity. They feed the Quality Score of 26/100, which measures business quality independently of the share price.
How far is QURE from its 52-week high?
Uniqure NV trades at $22.71, about 56% below its 52-week high of $51.05 and 151% above the low of $9.03 (as of Nov 10, 2026). Distance from the high says nothing about value: that is what the fair value of $13.97 is for.
Which stocks are comparable to Uniqure NV?
From the same area (Healthcare) we also value Vertex Pharmaceuticals Incorporated, Moderna, Inc, Regeneron Pharmaceuticals, Inc, CSL Limited, among others. Each of them has its own fair-value calculation on this site using the same models, so the comparison is like for like.
Is Uniqure NV stock attractive at the current price?
The data as of Nov 10, 2026: price $22.71, calculated fair value $13.97 (−38%), Quality Score 26/100. Whether that fits your horizon and risk tolerance is your call. We provide the calculation, not investment advice.
Is it still worth investing in stocks now?
The global stock market currently sits 15.1% above its aggregate fair value. Uniqure NV itself currently trades above fair value. An expensive market is no reason to stay out and no reason to buy everything at once: keep a broad savings plan running, buy single stocks only with money you can do without, and hold part of your money liquid while the market is high. The full picture including sectors is on is it worth investing now.
What is the share price of Uniqure NV (QURE)?
The closing price on Nov 10, 2026 was $22.71. Our estimate is $13.97, about 38% lower (overvalued). We carry closing prices from our data provider, not a live tick.
What should I pay attention to with Uniqure NV right now?
The price sits above even our optimistic bull case ($17.46). The favourable scenario is already priced in. Weak quality (26/100) and above fair value at the same time, the margin of safety is missing on both counts. The large gap to fair value rests on thin data (low evidence): fewer applicable models and a shorter history. Read it with extra caution.

Key figures of Uniqure NV

How large is the market capitalisation of Uniqure NV (QURE)?
The market capitalisation of Uniqure NV is $1.5B. The stock-market value of the whole company: share price times number of shares. It is what the market asks for the entire business today.
What is the P/S ratio of Uniqure NV (QURE)?
The price-to-sales ratio of Uniqure NV is 85.6 (last twelve months). Price to sales: market value relative to yearly revenue. Useful when profit is thin or distorted.
What are the earnings per share of Uniqure NV (QURE)?
Earnings per share at Uniqure NV are $−3.51. Earnings per share over the last twelve months: total profit spread across every single share.
What is the return on equity of Uniqure NV (QURE)?
The return on equity (ROE) of Uniqure NV is −158% (last twelve months). Profit relative to shareholders' equity, how efficiently the company works with its owners' money.
What is the EBIT return on assets of Uniqure NV (QURE)?
On an EBIT basis the return on assets of Uniqure NV is −14.4% (avg 5y). Operating profit (EBIT) relative to everything the company owns, as a multi-year average. It describes the business model rather than one good or bad year.
What is the operating margin of Uniqure NV (QURE)?
The operating margin of Uniqure NV is −872% (last twelve months). Profit from the core business (before interest and taxes) relative to revenue.
How fast is revenue growing at Uniqure NV (QURE)?
Revenue at Uniqure NV is growing +11.0% versus a year earlier (3y avg −46.7%). How much revenue grew versus a year earlier (YoY). The 3-year average next to it puts the single year in context.
How fast are earnings growing at Uniqure NV (QURE)?
Earnings per share at Uniqure NV are growing −18.2% versus a year earlier. How much earnings per share grew versus a year earlier.
How much free cash flow does Uniqure NV (QURE) generate?
The free cash flow of Uniqure NV is −$178M (fiscal year 2025). The cash truly left after running and investing in the business, this is what pays dividends and buybacks.
How much net debt does Uniqure NV (QURE) carry?
The net debt of Uniqure NV is $456M (fiscal year 2025). Debt minus cash on hand. The note shows how many years of free cash flow could in theory pay it off.
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