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Ultragenyx Pharmaceutical Inc (RARE) Fair Value & Analysis

Healthcare · US · Market cap $3.0B

UP Ultragenyx Pharmaceutical Inc logo Ultragenyx Pharmaceutical Inc RARE · US
Price$25.91
Fair Value$23.92
Upside-7.7%
Quality36/100
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Mixed Growth
Loss-making · -90.9% net margin
Negative equity (buybacks among others) · negative free cash flow
Trails peers (2/8)
Narrow moat 13/100
Evidence: Low Range $17.94 – $29.90 Share as image

Fair value as of: Jun 23, 2026

From 3 valuation models · updated 47 days ago

Share price −25.3% over the past month.

Below-average quality, currently priced close to our fair value.

What matters now

  • The price sits close to our fair value, market and models broadly agree here, little valuation tension.
  • Evidence is limited here (fewer models, shorter history), so the fair value is a rougher estimate than usual.
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Price vs Fair Value (5 years)

$115.71 $18.50 Fair Value $23.92 May 2021 Aug 2026

White line = price, green steps = our fair value per fiscal year, dashed = 300-day average. As of Jun 23, 2026.

How to read this chart

60‑month range $18.50 – $115.71 · fair‑value band $17.94 – $29.90 · the $25.91 price screens above the $23.92 fair value. Green steps = our fair value per fiscal year (point-in-time, no hindsight). Dashed = 300-day average. As of Jun 23, 2026.

Full chart & analysis →

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Analysis

Ultragenyx Pharmaceutical Inc (RARE) currently trades at $25.91, while our model-based Fair Value estimate is $23.92, implying the stock looks roughly 7.7% fairly valued today. The Quality Score stands at 36/100 (below-average quality), in the Healthcare sector. Bear case: priced above our estimate, the market already discounts strong expectations. Bull case: above-average quality can justify a premium, the entry price still matters most (evidence: low).

Over the trailing twelve months, Ultragenyx Pharmaceutical Inc generated revenue of $670M at a net margin of -90.9%. Revenue declined 2.2% year over year. Net debt stands at $842M. Fundamentals as of Jun 23, 2026

Our scenario range runs from $17.94 (bear case) to $29.90 (bull case); at $25.91, the current price sits within that range. Bear and bull are the same models run on conservative and optimistic assumptions (margins, growth, valuation multiples), so a plausible valuation range, not a price target. The share trades about 39% below its 52-week high and 42% above its 52-week low, currently below its 200-day average. For context, the median of 10 Healthcare peers we cover trades at -43% fair-value upside, at -8%, RARE screens cheaper than that median.

Key figures & financial health

Revenue (TTM) $670M
Revenue growth (YoY) -2.2%
Net margin -90.9%
Return on equity -608%
Free cash flow −$472M FY2025
Operating margin -102%
More key figures
EPS (TTM) $-6.10
Net debt $842M FY2025

Figures from reported company fundamentals · as of Jun 23, 2026. TTM = trailing twelve months.

Quality Score breakdown

Overall quality 36/100

Of which business quality 37 · Market factors (momentum, volatility) 45

Profitability 23
Margins and returns on capital today
Quality Growth 69
Are margins and returns improving?
Cashflow 7
Earnings quality: real cash, not paper profit
Fin. Strength 49
Balance sheet, leverage, solvency risk
Investment 100
Disciplined investing over empire-building
Low Volatility 50
Calm price path (market factor)
Momentum 51
Price trend over the last 3–12 months (market factor)
52W Momentum 29
Distance to the 52-week high (market factor)
Net Issuance 0
Buybacks instead of dilution

Non-valuation factor families (profitability, growth, cashflow, financial strength, momentum …), each academically grounded. Valuation itself sits in the Fair Value and is deliberately excluded here to avoid double-counting.

About the company

Ultragenyx Pharmaceutical Inc., a biopharmaceutical company, focuses on the identification, acquisition, development, and commercialization of novel products for the treatment of rare and ultra-rare genetic diseases in North America, Latin America, Europe, the Middle East, Africa, and the Asia-Pacific.

Full company description

Ultragenyx Pharmaceutical Inc., a biopharmaceutical company, focuses on the identification, acquisition, development, and commercialization of novel products for the treatment of rare and ultra-rare genetic diseases in North America, Latin America, Europe, the Middle East, Africa, and the Asia-Pacific. Its biologic products include Crysvita (burosumab), an antibody targeting fibroblast growth factor 23 for the treatment of X-linked hypophosphatemia, as well as tumor-induced osteomalacia; Mepsevii, an enzyme replacement therapy for the treatment of children and adults with Mucopolysaccharidosis VII; Dojolvi for the treatment of long-chain fatty acid oxidation disorders; and Evkeeza (evinacumab) for the treatment of homozygous familial hypercholesterolemia. The company's products candidates that are in Phase 3 clinical trials include UX143, a human monoclonal antibody for the treatment of osteogenesis imperfecta; UX111, an AAV9 gene therapy product candidate for the treatment of patients with Sanfilippo syndrome type A, or MPS IIIA, a rare lysosomal storage disease; DTX401, an adeno-associated virus 8 (AAV8) gene therapy clinical candidate for the treatment of patients with glycogen storage disease type Ia; DTX301, an AAV8 gene therapy for the treatment of patients with ornithine transcarbamylase; and GTX-102, an antisense oligonucleotide for the treatment of Angelman syndrome. It also develops UX701 that is in Phase 2 clinical trial for the treatment of Wilson disease; and UX053 for the treatment of glycogen storage disease type III. Ultragenyx Pharmaceutical Inc. has collaboration and license agreement with Kyowa Kirin Co., Ltd.; Saint Louis University; Baylor Research Institute; REGENXBIO Inc.; GeneTx; Mereo; University of Pennsylvania; Solid Biosciences Inc.; Regeneron; Abeona; and Arcturus Therapeutics Holdings Inc. The company was incorporated in 2010 and is headquartered in Novato, California.

Company description, as reported by the company or data provider.

Revenue & earnings trend

FY2021 – FY2025 · reported fiscal years

Ultragenyx Pharmaceutical Inc reported revenue of $673M in FY2025 versus $351M in FY2021, a compound +17.6%/yr. Reported net income was −$575M in FY2025.

Growth Quality 34/100
Revenue is growing, but margins or cash flow do not fully confirm the trend.
Latest Revenue (FY 2025)
$673M
Latest YoY
+20.1%
Avg. growth/yr (3Y)
+22.8%
Avg. growth/yr (5Y)
+19.9%
Avg. growth/yr (9Y)
+158.0%
Revenue +17.6%/yr
FY21 $351M
FY22 $363M
FY23 $434M
FY24 $560M
FY25 $673M
Net income
FY21 −$454M
FY22 −$707M
FY23 −$607M
FY24 −$569M
FY25 −$575M

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Cite: Fair Value Calculator (2026). "Ultragenyx Pharmaceutical Inc Fair Value". https://www.fairvalue-calculator.com/stock/RARE

Earlier news

External third-party headlines (Yahoo Finance, Reuters and others), not an editorial selection.

Peer Group

Biotechnology · 603 stocks

How this stock ranks against its industry: the green marker is this stock, the band is the typical 25–75% peer range, and the tick is the median.

Quality Score 36 · Below median
Fair Value upside −8% · Above median
Return on assets -25% · Below median
Net margin (TTM) -91% · Bottom 25%
Operating margin (TTM) -102% · Bottom 25%
Revenue growth -2% · Below median

Valuation Multiples vs Biotechnology median · lower = cheaper

P/S (TTM) 4.44× · Pricier than median

Snowflake

Five quick dimensions, each 0 to 100: VALUE (fair-value potential), FUTURE (revenue growth), PAST (return on equity), HEALTH (low debt), DIVIDEND (yield). Green = this stock, grey = typical sector peer.

VALUE 23 · sector 0
FUTURE 0 · sector 0
PAST 0 · sector 0
HEALTH 100 · sector 97
DIVIDEND 0 · sector 23

PAST 0: with negative equity (buybacks among others) return on equity is not meaningfully computable.

Insider activity: 40/100

Values & ESG

Does this company touch areas you may want to avoid? The classification is inferred from sector and industry.

None of the checked exposures detected

ESG scores are not available for this stock yet. Values and ESG data are contextual and can differ between providers.

Similar stocks

10 more Biotechnology stocks, each showing price versus our Fair Value estimate (as of Jun 23, 2026).

Stock Price Fair Value vs Fair Value
Vertex Pharmaceuticals Incorporated VRTX $486.03 $278.78 -43%
Regeneron Pharmaceuticals, Inc REGN $664.45 $594.40 -11%
Samsung Biologics Co 207940 1,368,000 KRW 1,091,384 KRW -20%
Celltrion, Inc 068270 175,800 KRW 76,325 KRW -57%
WuXi Biologics (Cayman) Inc 2269 HK$39.54 HK$30.42 -23%
Innovent Biologics, Inc 1801 HK$86.70 HK$19.66 -77%
Sino Biopharmaceutical Limited 1177 HK$5.26 HK$3.36 -36%
ALTEOGEN Inc 196170 276,500 KRW 44,444 KRW -84%
RemeGen Co 688331 ¥134.02 ¥26.99 -80%
Biocon Limited BIOCON ₹440.70 ₹57.36 -87%

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Frequently asked questions

Is Ultragenyx Pharmaceutical Inc (RARE) overvalued or undervalued?
As of Jun 23, 2026, our model estimates a fair value of $23.92 versus a price of $25.91, about −8% (fairly valued).
What is the fair value of RARE?
Our model-based fair value for Ultragenyx Pharmaceutical Inc is $23.92 (as of Jun 23, 2026), built from audited fundamentals. The current price is $25.91.
What is the quality score of RARE?
Ultragenyx Pharmaceutical Inc has a Quality Score of 36/100. It measures business quality (profitability, growth, cash flow, balance-sheet strength, investment discipline, share issuance). Market factors such as price momentum and volatility do not enter the number; they are shown separately in the detail view.
What is the revenue of Ultragenyx Pharmaceutical Inc (RARE)?
Ultragenyx Pharmaceutical Inc reported trailing-twelve-month revenue of about $670M (latest available figure, as of Jun 23, 2026).
What is the net profit margin of RARE?
The net profit margin of Ultragenyx Pharmaceutical Inc is about -90.9%, meaning it is currently running at a net loss. Based on the latest reported figures.

How we calculate Fair Value

Each company is valued through a stack of independent intrinsic-value models (DCF variants, residual-income, multiples and more), blended into one family-balanced consensus and weighted by how much trustworthy data backs it. A separate quality layer scores the fundamentals. Every input is real reported data, nothing guessed.

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