EN DE
Check 35,000+ stocks against 26 valuation models and 37 quality factors
Data-driven stock valuation

Septerna, Inc. (SEPN) fair value: what the stock is really worth

As of Sep 23, 2026: fair value of Septerna, Inc. $31.07, price $38.45, upside -19.2%, quality 55 out of 100. Calculated from audited financials with 26 valuation models and 37 quality factors, updated daily.

  1. Fair value above price? No
  2. Good quality? Yes
  3. Add to watchlist

Healthcare · US · ISIN US81734D1046

SI Septerna, Inc. logo Thin data Sep 23, 2026

Septerna, Inc.

SEPN · US

Overvalued / MonitorQuality is not strong enough to offset the price risk.

!Fair value $31.07 · Overvalued (−19%)
!Quality 55/100
!Mixed Growth (revenue YoY +4174.5 %/yr)
!Loss-making · -24.5% net margin (TTM)
✓generates free cash flow
!Mixed vs. peers (5/10)
!Narrow moat 10/100
!Insider activity 46/100
!Evidence only low, so the estimate is less certain
!Weak on valuation: 8 out of 100
Watch Septerna, Inc. Common Stock for free, get notified when fair value or trend changes. Plus fair value for all 35,000+ stocks, 14 days of Pro free, no card. Watch for free Pro now: $1 first month

What runs behind every stock

26 valuation models 8 families, DCF to NCAV 37 quality factors margins, balance sheet, cashflow, debt 6 AI factors moat, what no ratio measures 2,000+ data points verified, per stock, median

69 individual criteria per stock, every one traceable See the method →

Price vs Fair Value

$48.19 $5.02 Fair Value $31.07 Oct 2024 Sep 2026

White line = price, green steps = our fair value per fiscal year, dashed = 300-day average. As of Sep 23, 2026.

How to read this chart

23‑month range $5.02 – $48.19 · fair‑value band $20.99 – $33.93 · the $38.45 price screens above the $31.07 fair value. Green steps = our fair value per fiscal year (point-in-time, no hindsight). Dashed = 300-day average. As of Sep 23, 2026.

Follow Septerna, Inc. Common Stock in your weekly email

Every Wednesday you see whether Septerna, Inc. Common Stock is on track or worth a review, plus price against fair value. Free, up to 3 stocks.

We send you a confirmation link. Unsubscribe with one click.

Which stocks are undervalued right now? Check free Discover now →

Company profile

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases.

Show more

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves' disease and thyroid eye disease. In addition, it focuses on other therapeutic areas, including neurology, women's health, cardiovascular disease, and respiratory disease. It has global collaboration and license agreement with Novo Nordisk to discover, develop and commercialize multiple potential oral small molecule therapies for metabolic-related diseases based on certain specified molecular targets. The company was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.

Stock analysis

Septerna, Inc. Common Stock (SEPN) currently trades at $38.45, while our model-based Fair Value estimate is $31.07, implying the stock looks roughly 23.7% overvalued today.

Show more

Valuation

Bull case: the Growth DCF group reads highest at a median of $54.37 per share, and 2 of the 6 models we run sit above the $38.45 price.

Bear case: the Asset-Based group reads lowest at $5.48, and 4 of the 6 models stay below the price. Evidence for this calculation is low.

Scenario range: $20.99 (bear) to $33.93 (bull), the price of $38.45 sits above it. Bear and bull are the same models on cautious and optimistic assumptions, a range, not a price target.

Quality & growth

The Quality Score stands at 55/100 (solid quality), in the Healthcare sector.

Mixed Growth: Revenue is growing, but margins or cash flow do not fully confirm the trend.

Septerna, Inc. Common Stock reported revenue of $46.0M in FY2025 versus $0 in FY2022. Reported net income was −$48.9M in FY2025.

Key figures

Market cap $1.7B · P/S ratio 18.3 · EPS (TTM) $−0.5300 · Net margin −106% · Return on equity −6.3% · Return on assets (EBIT) −26.8% · Operating margin −63.0% · Revenue (TTM) $98.9M.

Competitive moat

Our AI-assisted moat analysis scores the competitive advantage at 38 out of 100 (low confidence).

What moves the price

The share trades about 20% below its 52-week high and 139% above its 52-week low, currently above its 200-day average.

For context, the median of 10 Healthcare peers we cover trades at −5% fair-value upside, at −19%, SEPN screens richer than that median.

Fair Value models

Bear $20.99 Fair Value $31.07 Bull $33.93
Model ⓘEach model values the company its own way (discounted cash flow, earnings, assets, dividends). The fair value above is their evidence-weighted blend, not the output of a single model. Bear ⓘBear = the cautious scenario: the same model computed with conservative anchors (lower growth, margins and valuation multiples). Together with Bull it frames a plausible valuation range, not a price target.BaseBull ⓘBull = the optimistic scenario: the same model computed with favourable anchors (higher growth, margins and valuation multiples). Together with Bear it frames a plausible valuation range, not a price target. Evidence ⓘEvidence = how well-backed THIS model's estimate is for this stock (0–100): how complete and reliable its input data are, and how well the model fits the company. The final Fair Value is an evidence-weighted blend, so better-evidenced models count more. Green ≥70, amber 50–69, grey below 50.
Highest evidence
FCF DCF $34.57 $49.27 $93.22 70
Growth DCF $32.55 $54.37 $88.67 69
5Y Revenue Exit $14.39 $17.74 $24.34 66
All 6 models by family
DCF Models
FCF DCF $34.57 $49.27 $93.22 70
5Y Revenue Exit $14.39 $17.74 $24.34 66
10Y Revenue Exit $21.19 $31.42 $34.34 61
Multiples
EV/Revenue $4.65 $5.54 $6.43 52
Asset-Based
NCAV (Graham) $4.09 $5.48 $8.18 51
Growth DCF
Growth DCF $32.55 $54.37 $88.67 69

Open the full fair value analysis →

Notify me when SEPN reaches fair value

Put SEPN on your watchlist. We get in touch as soon as price and fair value meet or the trend turns.

Set up alert →

Quality Score breakdown

Overall quality 55/100

Of which business quality 62 · Market factors (momentum, volatility) 60

Profitability 3
Margins and returns on capital today
Quality Growth 88
Are margins and returns improving?
Cashflow 100
Earnings quality: real cash, not paper profit
Fin. Strength 92
Balance sheet, leverage, solvency risk
Investment 50
Disciplined investing over empire-building
Low Volatility 0
Calm price path (market factor)
Momentum 86
Price trend over the last 3–12 months (market factor)
52W Momentum 85
Distance to the 52-week high (market factor)
Net Issuance 31
Share count: buybacks or dilution?

Open the full quality analysis →

Revenue & earnings trend

Growth Quality ⓘGrowth is valuable only when reinvestment earns attractive returns (Aswath Damodaran): sustainable growth depends on return on capital, reinvestment and efficiency. Basis: total company revenue over the periods shown on the cards (3Y/5Y/all years), not per share, so a merger can show up as a growth jump; per-share earnings growth is in the value-creation card. 56/100
Revenue is growing, but margins or cash flow do not fully confirm the trend.
What shareholders gained per year ⓘWe only publish this rate when it is defensible. Reason: fiscal 2025 is a loss year, no rate is defined from a loss
not computed

Growth Forecast

A lot of optimism in the price
The price assumes less growth than the company has delivered so far and more than analysts expect.
What the price assumes ⓘThis turns our valuation around: instead of asking what the share is worth, it asks what growth the current price requires. It uses the cash the company keeps after all spending (free cash flow), the same discount rate as our models, five years of growth, then slowing evenly to 2 % a year by year ten. Compared with the analysts' sales forecasts extended to the same five years (at least three analysts, for context only, it does not enter the Fair Value): within 3 percentage points counts as "in line" (amber), below that little optimism (green), above that a lot of optimism (red).
+3.9%
Yearly growth needed for the next five years to justify today's price.
What forecasts expect ⓘAnalysts publish sales forecasts for the next two fiscal years. For the years after that, growth slows evenly to 2 % a year by year ten (2 % is the long-run rate our models use). Projected years are marked as such.
+0.7%
Yearly sales growth analysts expect, extended to five years.
After inflation (USA: IMF forecast 2.4% a year to 2030, 3.1% from 2016 to 2025) that is about +1.5% a year for the price and −1.7% for the forecasts.
Forecast 2026 (sales)+67.5%
Forecast 2027 (sales)−14.4%
Projected 2028 (sales)−12.4%
Projected 2029 (sales)−10.3%
Projected 2030 (sales)−8.3%

SEPN screens 24% overvalued. Compare with Vertex Pharmaceuticals Incorporated →

Compare Septerna, Inc. Common Stock with another stock

Price, fair value, quality and upside side by side.

Free, no sign-up

Peer GroupⓘHow this stock ranks against its industry: the green marker is this stock, the band is the typical 25–75% peer range, and the tick is the median.Biotechnology · 651 stocks

Beats the industry median on 4/9 measures
A mixed picture versus its industry peers.
Valuation
Quality Score 55 · Above median
Fair Value upside −19% · Above median
Profitability
Return on assets −7% · Above median
Net margin (TTM) −25% · Below median
Operating margin (TTM) −63% · Bottom 25%
Growth and dividend
Revenue growth 224% · Top 25%

Valuation Multiplesvs Biotechnology median · lower = cheaper

P/B 4.53× · Priciest 25%
P/S (TTM) 17.51× · Priciest 25%
P/FCF 15.8× · Pricier than median

Strength profile in five axes (Snowflake)

VALUEFUTUREPASTHEALTHDIVIDEND
This stock
VALUEFUTUREPASTHEALTHDIVIDEND
Sector peers
VALUE (fair-value potential)8 · sector 0
FUTURE (revenue growth)100 · sector 0
PAST (return on equity)0 · sector 0
HEALTH (low debt)0 · sector 97
DIVIDEND (yield)0 · sector 23

Context: sector, industry, market

Values & ESG

Does this company touch areas you may want to avoid? The classification is inferred from sector and industry.

None of the checked exposures detected

Similar stocks

10 more Biotechnology stocks, each showing price versus our Fair Value estimate.

Stock Price Fair Value vs Fair Value
Vertex Pharmaceuticals Incorporated VRTX $514.99 $566.49 +10%
Regeneron Pharmaceuticals, Inc REGN $803.90 $1,252 +56%
argenx SE ARGX $963.79 $918.60 −5%
Samsung Biologics Co 207940 1,366,000 KRW 1,502,600 KRW +10%
CSL Limited CSL A$179.24 A$197.16 +10%
Alnylam Pharmaceuticals, Inc ALNY $251.65 $218.36 −13%
Royalty Pharma plc RPRX $58.52 $24.22 −59%
BeOne Medicines AG 6160 HK$218.20 HK$169.72 −22%
Celltrion, Inc 068270 177,400 KRW 74,519 KRW −58%
BioNTech SE BNTX $100.87 $63.62 −37%

Explore undervalued stocks

More undervalued Healthcare stocks →

All undervalued stocks TechnologyFinancial ServicesHealthcareConsumer CyclicalConsumer DefensiveCommunication ServicesIndustrialsEnergyBasic MaterialsReal EstateUtilities Deeply Undervalued StocksUndervalued High-Quality StocksUndervalued Blue-Chip StocksUndervalued Small-Cap StocksUndervalued Dividend Stocks

Try a ready-made strategy

Pick a strategy and jump into the live analysis with that exact screen applied.

🥇 Backtested Best 🏆 Big Names ⭐ Top Rated 💎 Quality on Sale 🚀 Profitable Growth 🧊 Quality Compounders 💵 Dividend Stars 📈 Strong Momentum 📉 Fallen Angels ⚖️ Deeply Undervalued 🔍 Small-Cap Gems 🏰 Moat at a Fair Price 💼 Insider Buying 🎩 Buffett-Style Quality 📚 Peter Lynch GARP 🧮 Greenblatt Magic Formula 🛡️ Graham Defensive

Discover tools

Stock screenerFilter by region, size and sector Compare toolTwo stocks side by side Extrinsic Value Calculator…Calculator with industry benchmark Peter Lynch Fair Value Formula &…Calculator with industry benchmark
Run the numbers yourself: free valuation calculators
DCF CalculatorGraham NumberPeter Lynch FormulaDDM CalculatorFama-French ModelIntrinsic Value
For bloggers & editors: embed code + live data

For bloggers, editors and developers: paste this into your site or blog (a “Custom HTML” block in WordPress), it shows the current fair value and links back here. Free, plain HTML, and welcome. Full data streams (CSV/JSON) at /developers.

Septerna, Inc. Common Stock · Fair Value
$31.07 −24%Fair Value
Calculator →

Cite: Fair Value Calculator (2026). "Septerna, Inc. Common Stock Fair Value". https://www.fairvalue-calculator.com/stock/SEPN

Frequently asked questions

Is Septerna, Inc. (SEPN) overvalued or undervalued?
As of Sep 23, 2026, our model estimates a fair value of $31.07 versus a price of $38.45, about −19% upside (overvalued).
What is the fair value of SEPN?
Our model-based fair value for Septerna, Inc. Common Stock is $31.07 (as of Sep 23, 2026), built from audited fundamentals. The current price: $38.45.
What is the quality score of SEPN?
Septerna, Inc. Common Stock has a Quality Score of 55/100. It measures business quality (profitability, growth, cash flow, balance-sheet strength, investment discipline, share issuance). Market factors such as price momentum and volatility do not enter the number; they are shown separately in the detail view.
What is the price target for Septerna, Inc. (SEPN)?
Our model-based price target is the fair value of $31.07 (as of Sep 23, 2026) from 6 valuation models. Cautious scenario $20.99, optimistic scenario $33.93. It is a calculation from audited fundamentals, not an analyst target.
What is the Septerna, Inc. Common Stock stock forecast for 2026?
Our models put fair value at $31.07, about −19% upside versus a price of $38.45 (overvalued). Cautious scenario $20.99, optimistic scenario $33.93. The calculation is refreshed regularly with new filings.
What is the revenue of Septerna, Inc. (SEPN)?
Septerna, Inc. Common Stock reported trailing-twelve-month revenue of about $98.9M (latest available figure, as of Sep 23, 2026).
What growth is priced into Septerna, Inc. (SEPN)?
For today's price to be fair in a discounted-cash-flow model, Septerna, Inc. Common Stock would have to grow free cash flow by +3.9 % per year for five years (discount rate 11.2 %, then slowing evenly to 2 % perpetual growth by year ten). Over the last 2 years revenue grew +1644.5 % per year. As of Sep 23, 2026.
What discount rate (WACC) does the fair value of SEPN use?
Our models discount Septerna, Inc. Common Stock at 11.2 %: a base by market capitalisation (small), country premium for USA. The same rate applies in all 26 models.
What is a reverse DCF?
A reverse DCF turns the usual calculation around. Instead of deriving a value from assumptions, it takes today's price as given and asks: what free-cash-flow growth would a company have to deliver for exactly this price to be fair? The result is not a forecast but the expectation already priced in. For Septerna, Inc. Common Stock that is +3.9 % per year a year over ten years, using the same discount rate (11.2 %) and the same formula as our fair value.
How much growth has Septerna, Inc. (SEPN) delivered so far?
Over the past 2 years revenue at Septerna, Inc. Common Stock grew +1644.5 % a year. The price currently implies +3.9 % per year free-cash-flow growth a year. Comparing the two shows how much confidence is in the price: if it demands more than has been delivered, the business has to accelerate for the maths to work.
How fast is the sector of Septerna, Inc. (SEPN) growing?
The median revenue growth in the sector is +4.2 % a year. That is the yardstick for the growth priced into Septerna, Inc. Common Stock (+3.9 % per year a year): it shows whether the expectation is within the usual range or beyond it.
What is the free cash flow yield of Septerna, Inc. (SEPN)?
The free-cash-flow yield on the price is 6.33 %: that much free cash flow Septerna, Inc. Common Stock produces per unit of market value. When it exceeds the discount rate of our models (11.2 %), the business already earns more than its cost of capital demands, and the price needs little additional growth.
What is the intrinsic value of Septerna, Inc. (SEPN)?
Intrinsic value and fair value mean the same thing: what the business is worth on its numbers, independent of the share price. For Septerna, Inc. Common Stock it is $31.07 per share (as of Sep 23, 2026), against a price of $38.45. It is the blended result of 6 valuation models (cash flow, earnings, asset, dividend).
Is Septerna, Inc. Common Stock stock overvalued or undervalued in 2026?
As of Sep 23, 2026, SEPN trades above its calculated fair value: price $38.45, fair value $31.07, a gap of about −19% (overvalued). The calculation is refreshed with each new quarterly report, so the verdict can change during the year.
Is fair value the same as the market price of SEPN?
No. The price is what the market pays today ($38.45); the fair value is what the company's own numbers justify ($31.07). For Septerna, Inc. Common Stock the two are $7.38 per share apart. That gap is exactly why we show both numbers side by side.
How much is Septerna, Inc. Common Stock worth?
The market values Septerna, Inc. Common Stock at about $1.7B (market capitalisation, as of Sep 23, 2026). Per share that is $38.45; our models calculate a fair value of $31.07 per share.
What do the bullish and bearish scenarios say about SEPN?
Our models span a range for Septerna, Inc. Common Stock: cautious scenario $20.99, base $31.07, optimistic $33.93 per share (as of Sep 23, 2026, price $38.45). The range comes from different growth and margin assumptions, not from analyst opinions.
How solid is the balance sheet of Septerna, Inc. (SEPN)?
Balance-sheet figures for Septerna, Inc. Common Stock (as of Sep 23, 2026): return on equity −6.3%. They feed the Quality Score of 55/100, which measures business quality independently of the share price.
How far is SEPN from its 52-week high?
Septerna, Inc. Common Stock trades at $38.45, about 20% below its 52-week high of $48.19 and 139% above the low of $16.06 (as of Sep 23, 2026). Distance from the high says nothing about value: that is what the fair value of $31.07 is for.
Which stocks are comparable to Septerna, Inc. Common Stock?
From the same area (Healthcare) we also value Vertex Pharmaceuticals Incorporated, Regeneron Pharmaceuticals, Inc, argenx SE, Samsung Biologics Co, among others. Each of them has its own fair-value calculation on this site using the same models, so the comparison is like for like.
Is Septerna, Inc. Common Stock stock attractive at the current price?
The data as of Sep 23, 2026: price $38.45, calculated fair value $31.07 (−19%), Quality Score 55/100, from 6 models. Whether that fits your horizon and risk tolerance is your call. We provide the calculation, not investment advice.
How is the fair value of SEPN calculated?
We run Septerna, Inc. Common Stock through 6 models from four families: discounted cash flow, earnings models, asset and balance-sheet models, and dividend models. Every model gets the same audited fundamentals; the result is the weighted average of $31.07, with the spread shown as a cautious and an optimistic scenario.
Is it still worth investing in stocks now?
The global stock market currently sits 14.1 % above its aggregate fair value. Septerna, Inc. Common Stock itself currently trades above fair value. An expensive market is no reason to stay out and no reason to buy everything at once: keep a broad savings plan running, buy single stocks only with money you can do without, and hold part of your money liquid while the market is high. The full picture including sectors is on is it worth investing now.
What is the share price of Septerna, Inc. (SEPN)?
The closing price on Sep 23, 2026 was $38.45. Our model-based fair value is $31.07, about −19% upside (overvalued). We carry closing prices from our data provider, not a live tick.
What should I pay attention to with Septerna, Inc. Common Stock right now?
The price sits above even our optimistic bull case ($33.93). The favourable scenario is already priced in. Solid but not exceptional quality (55/100) and above fair value, neither a clear bargain nor a standout compounder. Evidence is limited here (fewer models, shorter history), so the fair value is a rougher estimate than usual.

Key figures of Septerna, Inc. Common Stock

How large is the market capitalisation of Septerna, Inc. (SEPN)?
The market capitalisation of Septerna, Inc. Common Stock is $1.7B. The stock-market value of the whole company: share price times number of shares. It is what the market asks for the entire business today.
What is the P/S ratio of Septerna, Inc. (SEPN)?
The price-to-sales ratio of Septerna, Inc. Common Stock is 18.3 (last twelve months). Price to sales: market value relative to yearly revenue. Useful when profit is thin or distorted.
What are the earnings per share of Septerna, Inc. (SEPN)?
Earnings per share at Septerna, Inc. Common Stock are $−0.5300. Earnings per share over the last twelve months: total profit spread across every single share.
What is the net margin of Septerna, Inc. (SEPN)?
The net margin of Septerna, Inc. Common Stock is −106% (fiscal year 2025). How much of every unit of revenue ends up as profit. 10% means 10 cents of profit per dollar of sales.
What is the return on equity of Septerna, Inc. (SEPN)?
The return on equity (ROE) of Septerna, Inc. Common Stock is −6.3% (last twelve months). Profit relative to shareholders' equity, how efficiently the company works with its owners' money.
What is the EBIT return on assets of Septerna, Inc. (SEPN)?
On an EBIT basis the return on assets of Septerna, Inc. Common Stock is −26.8% (avg 4y). Operating profit (EBIT) relative to everything the company owns, as a multi-year average. It describes the business model rather than one good or bad year.
What is the operating margin of Septerna, Inc. (SEPN)?
The operating margin of Septerna, Inc. Common Stock is −63.0% (last twelve months). Profit from the core business (before interest and taxes) relative to revenue.
How fast is revenue growing at Septerna, Inc. (SEPN)?
Revenue at Septerna, Inc. Common Stock is growing +224% versus a year earlier. How much revenue grew versus a year earlier (YoY). The 3-year average next to it puts the single year in context.
How much net cash does Septerna, Inc. (SEPN) hold?
Septerna, Inc. Common Stock holds more cash than debt, $97.1M net (fiscal year 2025). The company holds more cash than debt, a safety cushion.
Free · no account needed

Watch Septerna, Inc. Common Stock in the live analysis

One click puts Septerna, Inc. Common Stock on your watchlist: fair value and trend at a glance, plus comparison, the diversification check and the 35,000+ stock screener. You can also try 14 days of Pro there, no card.

Watch for free →

Zero risk: nothing is ever charged. Your watchlist is yours, with or without an account.